2020
In an exploratory randomized, double-blind, placebo-controlled, cross-over study, psychoactive doses of intravenous delta-9-tetrahydrocannabinol fail to produce antinociceptive effects in healthy human volunteers
Schindler EAD, Schnakenberg Martin AM, Sewell RA, Ranganathan M, DeForest A, Pittman BP, Perrino A, D’Souza D. In an exploratory randomized, double-blind, placebo-controlled, cross-over study, psychoactive doses of intravenous delta-9-tetrahydrocannabinol fail to produce antinociceptive effects in healthy human volunteers. Psychopharmacology 2020, 237: 3097-3107. PMID: 32632491, DOI: 10.1007/s00213-020-05595-9.Peer-Reviewed Original ResearchConceptsCapsaicin-induced hyperalgesiaCross-over studyHealthy human subjectsIntravenous THCAcute painAntinociceptive effectDrug effectsDrug AdministrationHuman subjectsDose-related mannerPeak drug effectHealthy human volunteersSignificant antinociceptive propertiesRationaleAnimal studiesElectrical painPain conditionsPain managementChemical painPain ratingsAntinociceptive propertiesHealthy volunteersPsychoactive dosesAcute chemicalHuman studiesCognitive alterations
2017
Tetrahydrocannabinol (THC) impairs encoding but not retrieval of verbal information
Ranganathan M, Radhakrishnan R, Addy PH, Schnakenberg-Martin AM, Williams AH, Carbuto M, Elander J, Pittman B, Sewell R, Skosnik PD, D'Souza DC. Tetrahydrocannabinol (THC) impairs encoding but not retrieval of verbal information. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2017, 79: 176-183. PMID: 28642081, DOI: 10.1016/j.pnpbp.2017.06.019.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAdultDouble-Blind MethodDronabinolFemaleHumansLearningMaleMarijuana AbuseMental RecallNeuropsychological TestsPsychotropic DrugsSpeech PerceptionYoung AdultConceptsRey Auditory Verbal Learning TestVerbal informationInfluence of tetrahydrocannabinolVerbal Learning TestMemory-impairing effectsTotal immediate recallNon-verbal informationImpairs memory consolidationAdministration of tetrahydrocannabinolAcute memory impairmentPrincipal psychoactive constituentVerbal memoryImmediate recallIntravenous tetrahydrocannabinolLearning TestMemory consolidationComponent processesNeural synchronyMemory impairmentInformation processingUse of cannabisCannabis intoxicationRecallPsychoactive constituentEncoding