2011
Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis
Calvo CF, Fontaine RH, Soueid J, Tammela T, Makinen T, Alfaro-Cervello C, Bonnaud F, Miguez A, Benhaim L, Xu Y, Barallobre MJ, Moutkine I, Lyytikkä J, Tatlisumak T, Pytowski B, Zalc B, Richardson W, Kessaris N, Garcia-Verdugo JM, Alitalo K, Eichmann A, Thomas JL. Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis. Genes & Development 2011, 25: 831-844. PMID: 21498572, PMCID: PMC3078708, DOI: 10.1101/gad.615311.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedEnzyme-Linked Immunosorbent AssayImmunohistochemistryLymphangiogenesisMiceMice, Mutant StrainsMicroscopy, Electron, TransmissionNeovascularization, PhysiologicNeural Stem CellsNeurogenesisOligonucleotide Array Sequence AnalysisReverse Transcriptase Polymerase Chain ReactionVascular Endothelial Growth Factor Receptor-3ConceptsNeural stem cellsSubventricular zoneVEGF receptorsNeural cellsVEGFR-3Vascular endothelial growth factor (VEGF) familyEndothelial growth factor familyVascular endothelial growth factor receptor 3VEGFR-3 expressionMultipotent neural stem cellsCapillary endothelial cellsGrowth factor receptor 3Overexpression of VEGFGrowth factor familyAdult neurogenesisSVZ neurogenesisReporter miceReceptor 3NeurogenesisNeurodegenerative diseasesConditional deletionEndothelial cellsGrowth factorLigand VEGFInducible deletion
2007
The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching
Suchting S, Freitas C, le Noble F, Benedito R, Bréant C, Duarte A, Eichmann A. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 3225-3230. PMID: 17296941, PMCID: PMC1805603, DOI: 10.1073/pnas.0611177104.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmyloid Precursor Protein SecretasesAnimalsCalcium-Binding ProteinsEndothelium, VascularGamma-Aminobutyric AcidImmunohistochemistryIn Situ HybridizationIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceMice, Mutant StrainsReceptors, Vascular Endothelial Growth FactorRetinal VesselsSignal TransductionTriglyceridesVascular Endothelial Growth Factor AConceptsTip cell formationEndothelial tip cell formationTip cellsNotch ligand DeltaCell formationCell marker genesEndothelial tip cellsVessel branchingLigand DeltaExpression of Dll4Vascular network formationTransmembrane ligandsNotch receptorsMarker genesNegative regulatorAngiogenic sproutingVEGF receptor 2VEGF stimulationFilopodia extensionGamma-secretase inhibitorsGrowth factor VEGFVascular sproutingPharmacological inhibitionDll4Heterozygous deletion
2001
Development of the avian lymphatic system
Wilting J, Papoutsi M, Othman‐Hassan K, Rodriguez‐Niedenführ M, Pröls F, Tomarev S, Eichmann A. Development of the avian lymphatic system. Microscopy Research And Technique 2001, 55: 81-91. PMID: 11596153, DOI: 10.1002/jemt.1159.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBirdsChick EmbryoEndothelial Growth FactorsEndothelium, LymphaticHomeodomain ProteinsImmunohistochemistryIn Situ HybridizationLymphatic SystemQuailReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorTumor Suppressor ProteinsVascular Endothelial Growth Factor CHemangioblast Commitment in the Avian Allantois: Cellular and Molecular Aspects
Caprioli A, Minko K, Drevon C, Eichmann A, Dieterlen-Lièvre F, Jaffredo T. Hemangioblast Commitment in the Avian Allantois: Cellular and Molecular Aspects. Developmental Biology 2001, 238: 64-78. PMID: 11783994, DOI: 10.1006/dbio.2001.0362.Peer-Reviewed Original ResearchMeSH KeywordsAllantoisAnimalsCell LineageChick EmbryoCoturnixDNA-Binding ProteinsEndodermErythroid-Specific DNA-Binding FactorsGATA2 Transcription FactorGATA3 Transcription FactorHematopoietic Stem CellsImmunohistochemistryIn Situ HybridizationLeukocyte Common AntigensMesodermModels, BiologicalProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorRNA, MessengerTime FactorsTrans-ActivatorsTranscription FactorsConceptsGATA-2Allantoic budCommitment of mesodermTranscription factor GATA-2SCL/talHemopoietic cellsHemangioblast commitmentEndoderm specificationOrgan formationGATA-1Definitive lineageStage HH17Blood islandsBlood island-like structuresEndodermMolecular processesMesodermEngrafted hostsMolecular aspectsHemopoietic lineagesGene patternsYolk sacBudsQuail embryosEmbryos