2014
The BCL6 RD2 Domain Governs Commitment of Activated B Cells to Form Germinal Centers
Huang C, Gonzalez DG, Cote CM, Jiang Y, Hatzi K, Teater M, Dai K, Hla T, Haberman AM, Melnick A. The BCL6 RD2 Domain Governs Commitment of Activated B Cells to Form Germinal Centers. Cell Reports 2014, 8: 1497-1508. PMID: 25176650, PMCID: PMC4163070, DOI: 10.1016/j.celrep.2014.07.059.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCell MovementCytokinesDNA-Binding ProteinsGerminal CenterHistone Deacetylase 2Lymphocyte ActivationMiceMutationProtein BindingProtein Structure, TertiaryProto-Oncogene Proteins c-bcl-6Receptors, G-Protein-CoupledReceptors, LysosphingolipidSphingosine-1-Phosphate ReceptorsT-Lymphocytes, Helper-InducerConceptsInnate immune cell phenotypesGC Tfh cellsImmune cell phenotypesT helper cellsGerminal center formationB cells migrateActivated B cellsB cell migrationHelper cellsInflammatory diseasesInterfollicular zonesTranscriptional repressor functionExtrafollicular responseGerminal centersB cellsImmune systemReceptor S1PR1MiceRepression domainRD2 domainRepressor functionCell migrationCells migrateCenter formationBiochemical specificity
2007
New markers for murine memory B cells that define mutated and unmutated subsets
Anderson SM, Tomayko MM, Ahuja A, Haberman AM, Shlomchik MJ. New markers for murine memory B cells that define mutated and unmutated subsets. Journal Of Experimental Medicine 2007, 204: 2103-2114. PMID: 17698588, PMCID: PMC2118690, DOI: 10.1084/jem.20062571.Peer-Reviewed Original ResearchConceptsMemory B cellsMurine memory B cellsB cellsAntigen-specific memory B cellsMemory B cell subsetsMemory B cell markersNon-Tg miceExpression of CD80B-cell markersB cell subsetsTransgenic mouse modelCell subsetsSplenic folliclesMemory compartmentMouse modelNaive precursorsMutation statusCell markersUnmutated subsetDefinitive markerMemory cellsAnatomic heterogeneityNew markersCell number
1999
A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus
Chan O, Hannum L, Haberman A, Madaio M, Shlomchik M. A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus. Journal Of Experimental Medicine 1999, 189: 1639-1648. PMID: 10330443, PMCID: PMC2193634, DOI: 10.1084/jem.189.10.1639.Peer-Reviewed Original ResearchConceptsB cellsAutoantibody productionMRL/MpJ-Faslpr miceAutoreactive T cellsAntigen-presenting cellsAntibody-independent roleB cell functionFunctional B cellsExpression of diseaseSerum autoantibodiesMurine lupusLocal inflammationSystemic autoimmunitySerum antibodiesPathogenic roleAntigen presentationT cellsCellular infiltrationSurface immunoglobulinPathologic phenotypeDisease expressionCell functionMiceNovel mousePrecise role