Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips
Gudimchuk N, Vitre B, Kim Y, Kiyatkin A, Cleveland DW, Ataullakhanov FI, Grishchuk EL. Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips. Nature Cell Biology 2013, 15: 1079-1088. PMID: 23955301, PMCID: PMC3919686, DOI: 10.1038/ncb2831.Peer-Reviewed Original ResearchMeSH KeywordsCell Cycle ProteinsCell MovementChromosomal Proteins, Non-HistoneChromosome SegregationGene ExpressionHeLa CellsHumansKinetochoresMechanotransduction, CellularMicrotubulesMitosisProtein TransportSpindle ApparatusConceptsDynamic microtubule endsMicrotubule endsMicrotubule tipsKinetochore kinesin CENPCENP-E motorDynamic microtubule tipsSingle-molecule approachVertebrate mitosisSpindle microtubulesTail domainCENPStable associationKinetochoresPlus endsChromosomesMolecular frameworkCentromeresMitosisMicrotubulesTransportersMotor mechanismsStability of attachmentVitroActive roleComputational modelling