2013
Refinement of a DNA based Alzheimer disease epitope vaccine in rabbits
Ghochikyan A, Davtyan H, Petrushina I, Hovakimyan A, Movsesyan N, Davtyan A, Kiyatkin A, Cribbs D, Agadjanyan M. Refinement of a DNA based Alzheimer disease epitope vaccine in rabbits. Human Vaccines & Immunotherapeutics 2013, 9: 1002-1010. PMID: 23399748, PMCID: PMC3899134, DOI: 10.4161/hv.23875.Peer-Reviewed Original ResearchConceptsDNA epitope vaccineEpitope vaccineTh epitopesAlzheimer's diseaseStrong humoral immune responseHumoral immune responseB-cell epitopesΒ-amyloid peptideN-terminal aspartic acidDNA vaccinePoor immunogenicityAD therapyHuman β-amyloid peptideImmune responseAD casesBrain sectionsCell epitopesEfficacy studiesVaccineEx vivoRhesus monkeysImmunogenicityShort amyloidEpitopesRabbits
2003
Immunization with a plant-produced colorectal cancer antigen
Verch T, Hooper D, Kiyatkin A, Steplewski Z, Koprowski H. Immunization with a plant-produced colorectal cancer antigen. Cancer Immunology, Immunotherapy 2003, 53: 92-99. PMID: 14566428, PMCID: PMC11032813, DOI: 10.1007/s00262-003-0428-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibody-Dependent Cell CytotoxicityAntigens, NeoplasmBaculoviridaeCancer VaccinesCell Adhesion MoleculesComplement System ProteinsCytotoxicity, ImmunologicEnzyme-Linked Immunosorbent AssayEpithelial Cell Adhesion MoleculeFemaleGenetic VectorsHumansImmunizationLymphocyte ActivationMiceMice, Inbred BALB CNeoplasms, ExperimentalPlants, Genetically ModifiedT-LymphocytesTobacco Mosaic VirusConceptsSame antigenSimilar humoral immune responsesColorectal cancer antigenTumor-associated antigensHumoral immune responseGA733-2Cancer vaccinationCancer vaccinesActive immunizationColorectal cancer vaccineCancer antigensImmune responseCell culturesAntigen preparationsImmunizationAntigenSafety concernsCellular responsesVaccinationMetastasisVaccineMiceOncology