2024
Right Ventricular Dysfunction in Patients Undergoing High-Risk PCI with Impella
Rommel K, Bonnet G, Bellumkonda L, Lansky A, Zhao D, Thompson J, Zhang Y, Redfors B, Lurz P, Granada J, Bharadwaj A, Basir M, O'Neill W, Burkhoff D. Right Ventricular Dysfunction in Patients Undergoing High-Risk PCI with Impella. Journal Of Cardiac Failure 2024, 30: 1244-1254. PMID: 39389734, DOI: 10.1016/j.cardfail.2024.08.001.Peer-Reviewed Original ResearchConceptsRight ventricular dysfunctionHigh-risk percutaneous coronary interventionVentricular dysfunctionAssociated with right ventricular dysfunctionTricuspid annular plane systolic excursionConcomitant right ventricular dysfunctionLower left ventricular ejection fractionUnfavorable long-term prognosisAnnular plane systolic excursionClinical outcomes of patientsAbsence of right ventricular dysfunctionImpella supportPredictor of 1-year mortalityMultivariate Cox regression analysisIncidence of hypotensive episodesEchocardiography core laboratorySevere RV dilatationBlood urea nitrogen levelsRV function assessmentVentricular ejection fractionOutcomes of patientsRates of in-hospital mortalityHigher blood urea nitrogen levelsLong-term prognosisProportion of patientsClinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR Results of a Patient-Level Pooled Analysis
Lansky A, Grubman D, Dwyer M, Zivadinov R, Parise H, Moses J, Shah T, Pietras C, Tirziu D, Gambone L, Leon M, Nazif T, Messé S. Clinical Significance of Diffusion-Weighted Brain MRI Lesions After TAVR Results of a Patient-Level Pooled Analysis. Journal Of The American College Of Cardiology 2024, 84: 712-722. PMID: 39142725, DOI: 10.1016/j.jacc.2024.05.055.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementClinical ischemic strokeAcute brain infarctionDW-MRIReceiver operating characteristicIschemic strokeTranscatheter aortic valve replacement resultBrain infarctionPatient-level pooled analysisC-statisticBrain MRI lesionsAcute ischemic brain injuryDiffusion-weighted magnetic resonance imagingAortic valve replacementIndividual lesion volumesCore laboratory analysisIschemic brain injuryPredicting ischemic strokeMagnetic resonance imagingStroke Prevention TrialMRI lesionsValve replacementDW-MRI acquisitionsPatient-level dataPooled analysis
2022
Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients
Van Mieghem N, Deeb G, Søndergaard L, Grube E, Windecker S, Gada H, Mumtaz M, Olsen P, Heiser J, Merhi W, Kleiman N, Chetcuti S, Gleason T, Lee J, Cheng W, Makkar R, Crestanello J, George B, George I, Kodali S, Yakubov S, Serruys P, Lange R, Piazza N, Williams M, Oh J, Adams D, Li S, Reardon M, Gitter C, Meyer K, Roberts D, Bae R, Sorajja P, Sun B, Askew J, Eales F, Flavin T, Goessl M, Kshettry V, Mooney M, Pedersen W, Poulose A, Roohani P, Saeid Farivar R, Shronts R, Tarrel R, Young M, Butkus E, Pendleton K, Fry R, Heine C, La Roe K, Tran T, Weig L, Agarwal H, Langdon T, Satpathy R, Batter J, Bremer K, Indukuri U, Baas M, Oomes-Sistermans C, Smits M, Coenen C, Driesen I, Lauryssen L, Poorter M, Schaap J, Bentala M, den Heijer P, Pieter J, Remmers M, Story M, van Erven P, Verbiest H, Vos J, Bennett M, Dunaj W, Seaton D, Waller D, Khandheria B, Bajwa T, O'Hair D, Ahmed A, Allaqaband S, Gheith A, Marriott E, Qhavi A, Saxena V, Shhadeh A, Werner P, Yeomans C, Bessette L, Byrne J, Kieckhefer H, Munoz M, Russo E, Klein J, Morgan M, Byrne T, Caskey M, Amabile O, Brady K, Chung S, Dacanay K, Fang H, Franz D, Kelly C, Loli A, Payne J, Pershad A, Wang N, Lott J, Pool-Owens C, Porter C, Hennan J, Garrett H, Paulus B, Craig J, Elijovich L, Samaha J, Wolf B, Wright L, Zoghbi G, Willcott L, Roberts B, Hebeler R, Stoler R, Graybeal D, Grayburn P, Henry C, Mir O, Vallabhan R, Fanous M, Kaufman J, Chang J, Manning W, Riley M, Khabbaz K, Laham R, Popma J, Burke D, Caplan L, Chui S, Guibone K, Kumar S, Lioutas V, Liu D, Nathan S, Pinto D, Searls D, Fisher S, Guirgues L, Henderson S, Loving L, McWalters N, Patterson K, Burkart J, Carcedo B, Stacey R, Bladergroen M, Lim D, Edmonson S, Epps S, Katz M, Ng K, Sangha A, Aucoin J, Roberts M, Aubin J, Hotard C, Tassin M, Fail P, Feinberg E, Netherland D, Abben R, Allam M, Bates M, Dearman R, Gervais D, Haight E, Metes M, Naquin J, Tedesco V, Thibodeaux L, Thompson K, Aberle S, Amaro D, Grey W, Rose G, Scherer M, Rinaldi M, Skipper E, Bridges C, Downey W, Iyengar P, Martin J, Ryan L, Stiegel R, Story J, Alsabaawi K, Gheorghiu M, Singh C, Yashar J, Siegel R, Cheng W, Makkar R, Altman K, Jilaihawi H, Kar S, Khouw S, Mody C, Ramzy D, Salseth T, Stegic J, Trento A, Lazarte R, Sohn J, Hahn R, Khalique O, George I, Kodali S, Williams M, Gonzalez Castellon M, Gutierrez Contreras J, Kitago T, Kummer B, Lekic T, Miller E, Naka Y, Nazif T, Qureshi A, Rostanski S, Smith C, Willey J, Yaghi S, Abreu L, Clement E, Sabir S, Aji J, Bowen F, Kaddissi G, Mirsen T, Muntazar M, Ogbara J, Rosenbloom M, Schell W, Then R, Carl H, Huang H, Kreydi G, Wolak H, Sandidge G, Ali O, Asfaw Z, Henry S, Kafi A, Schreiber T, Andaya L, Baciewicz F, Bassett J, Choksi N, Kassas S, Munir A, Kothmeier F, Stroh A, Goppel G, Hettich I, Bleiziffer S, Hengstenberg C, Opitz A, Ruge H, Badiu C, Brenner S, Ehlmidi Y, Herold U, Kasel A, Kreuzpointner R, Lange R, Mazzitelli D, Poppert H, Seifert C, Vincze D, Voss B, Camuglia K, Cowhig D, Newbold S, Pierce C, Wootton S, Vemulapalli S, Velazquez E, Harrison J, Hughes G, Ali Y, Babi A, Banks A, Gaca J, Glower D, Gokhale S, Halim S, Hendry R, Hernandez C, Kiefer T, Klein M, Kolls B, Marrotte E, Pineda Maldonado A, Price A, Sherwood M, Swisher C, Van Wyck D, Vavalle J, Vora A, Wang A, Zeylikman Y, Amber K, Barnitt A, Lamm J, Mandelstam L, Schroeder R, Sumner R, Nair D, De A, Gaudiani V, Joye J, Brown L, Hessler C, Rammohan C, Vial C, Charles E, DeQuesada A, Kaner M, Mathewson S, Pitts K, Wheeler L, Wilson A, Davidson E, Frohwein S, Lerakis S, Merlino J, Sullivan A, Babaliaros V, Guyton R, Thourani V, Anderson A, Belagaje S, Benameur K, Devireddy C, Greene J, Harrison A, Hudson K, Leshnower B, Lieppe W, Macheers S, Mavromatis K, Miller J, Nahab F, Sanders K, Sarin E, Stewart J, Winkel D, Duininck L, Gussinklo T, Jadoenath-Oedai S, Ruiter A, van den Berg N, van der Velden-Macauley L, van Huis M, Verelst S, Geleijnse M, Vletter W, Bekker M, Kappetein A, Van Mieghem N, Bekkers J, Biesheuvel K, Birim O, Bol Raap G, Daemen J, de Jaegere P, de Lind van Wijngaarden R, Khajeh L, Kik C, Koudstaal P, Oei F, Scheele M, van de Woestijne P, van Geuns R, van Leeuwen W, Henderson A, Straight F, Schneider D, Tischler M, Dauerman H, Ittleman F, Schmoker J, Abernethy A, Alkhalil I, Azarbal A, Chava S, Commichau C, Coyle D, Denkmann J, Destephan C, Ehle G, El-Haddad M, Falduto C, Gorman M, Kadavath S, Leavitt B, Mack A, Malasana G, Moossavi S, Phuong N, Rambod M, Seecheran N, Sharma A, Terrien E, Worgan B, Zeglin-Sawczuk M, Burgess B, Killbride S, Temple A, Burnside J, Good C, Agarwal S, Casale A, Skelding K, Carter R, Cummings C, Grana V, Haegerl C, Harjai K, Holland N, Singh D, Stahl R, Stella J, Stewart B, Long D, Wood K, Alexander D, Barton S, Logtens E, Marsh A, McAdam J, Kovac J, Mariscalco G, Spyt T, Garimella S, Szostek J, Zlocha V, Kirkland L, Reid L, Reilly S, Menderhall M, Martin W, Park S, Seshiah P, Smith J, Gersch K, Hiratzka L, Kachoris J, Okum E, Cardozo M, Cyr G, Duvall W, Flynn A, Krupowies N, Parker M, Hagberg R, McKay R, Azemi T, Brown R, Fusco D, Hammond J, Hosley C, Kiernan F, Margey R, Preissler P, Sadiq I, Silverman I, Taboada S, Underhill D, Escobar J, Lopez B, Mullin S, Quesada C, Lawrence T, Naqvi T, Matthews R, Starnes V, Clavijo L, Cunningham M, Kim-Tenser M, Sanossian N, Shavelle D, DelMotte D, Henry S, Moltrassie J, Solanki A, Cooper R, Lee J, Parikh S, Wang D, Zweig B, O'Neill W, Paone G, Borgi J, Brewer R, Eng M, Greenbaum A, Guerrero M, Miller D, Mitsias P, Morgan J, Nemeh H, Alcaide Muñoz J, Medina Fernandez M, Carrasco Chinchilla F, Rodríguez Bailón I, Hernández García J, Such M, Alonso-Briales J, De La Cruz Cosme C, Dominguez-Franco A, Mataró López M, Melero J, Muñoz-Garcia A, Sanchez Espin G, Fernández Maese J, Torres M, Villa Suarez E, De La Hera J, Llosa Cortina J, Morís de la Tassa C, Avanzas Fernández P, Benavente Fernández L, Calleja S, Del Valle R, Morales Pérez C, Silva J, Bluntschli E, Keller D, Maritz S, Ruest R, 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Bloomfield C, Burtonwood N, Harland C, Somers K, Ware T, Deakin S, Geldard S, Schlosshan D, Blackman D, Kaul P, Evans B, Javangula K, Limaye S, Malkin C, Wanklyn P, Farhi A, Manapat A, Maranan L, Mihelis E, Ng A, Ricketts M, Kronzon I, Perk G, Brinster D, Kliger C, Azhar S, Bonomo R, Dharva R, Fontana G, Mandel S, Mehla P, Patel N, Plestis K, Fox S, Mardell S, Novick T, Sandie K, de Jonge W, McLeod C, Mroz L, Weigand A, Chu M, Kiaii B, Teefy P, Bagur R, Debicki D, Diamantouros P, Gofton T, Mandzia J, McKenzie F, Mirsattari S, Valdis M, Young B, Klein W, Sawicki K, Dajani K, Darki A, Bakhos M, Leya F, Biller J, Lewis B, Morales-Vidal S, Schneck M, Schwartz J, Tuchek J, Biddle A, Ernst D, Haubenschild J, Howe-Clayton D, Johnson R, Mundt P, Reiter J, Bruce C, Freeman W, Kutzke K, Maalouf J, Nkomo V, Pislaru S, Sinak L, Pochettino A, Sandhu G, Alkhouli M, Best P, Bresnahan J, Eleid M, Fulgham J, Greason K, Gulati R, Holmes D, Maor E, Mathew V, Meissner I, Panaich S, Peterson A, Radford J, Raphael C, Reeder G, Sanon S, Sarraf M, Scharf E, Suri R, Swenson C, Williams L, Jiang Z, Lapierre S, Phan T, Buithieu J, de Varennes B, Piazza N, Lachapelle K, Liam D, Martucci G, Blömer H, Herder W, Van der Geest E, van der Wal M, Izaksson R, Kootstra H, Pultrum M, Walinga T, Boonstra P, van Boven A, Amrane H, Hofma S, Schuiling W, Terluin H, Timmerman M, van der Weerdt A, van Rooij F, Vossenberg T, Barnes C, Griffin S, Goldstein S, Marcus R, Wang Z, Widell J, Bafi A, Waksman R, Choi J, Corso P, Laureno R, Lin M, Lowery R, Malla P, Pichard A, Satler L, Shults C, Decklever C, Evans D, Tuttle K, Klein M, Marcus R, Chawla A, Hockmuth D, Jacoby M, Jenson B, McAllister D, Prabhakar G, Verhofste M, Morin C, Potvin L, St. Jean N, Garceau P, Asgar A, Cartier R, Bonan R, Dominquez M, Dorval J, Ibrahim R, Lavoie M, Benner A, Brunetti D, Ciprich C, Lobur E, Lonergan N, McGlew S, Oplinger J, Oster T, Polise L, Purpura J, Sentman S, Van Zile C, Arogundade O, Gillan L, Koulogiannis K, Brown J, Kipperman R, Blitz L, Cohen B, English K, Genereux P, Magovern C, Rosenberg R, Safirstein J, Slater J, Turner J, Xydas S, Jones T, Montgomery S, Barry M, Kovach T, Navas J, Patel V, Lin L, Rovin J, Arora A, Ofenloch J, Schneider J, Spriggs D, Stone L, Turner N, Basnet S, Bhat A, Fusilero M, Muthiki S, Muthyala S, Saint Vrestil N, Sharma M, Singh J, Chaudhry F, Sengupta P, Adams D, Sharma S, Tang G, Anyanwu A, Bronster D, Dangas G, Kini A, Stelzer P, Stewart A, Swain J, Annunziato S, Chan G, Delliliune D, Garzon R, Seeratan V, Rosman D, Suma V, Trost B, Hartman A, Katz S, Rutkin B, Boutis L, Carey R, DeAngelis T, DeOrchis V, Esposito R, Han M, Jauhar R, Kaplan B, Laighold S, Meraj P, Palazzo R, Parihar R, Podwall D, Wright P, Yu P, Abu M, Bavbekova S, Bowden M, Clark E, Gaudio S, Houanche P, Kalish C, Kapitman A, Lee H, Morales V, Oviedo F, Pushkar I, Robin T, Shaheen D, Sin D, Taylor Z, Tovar J, Van Daele J, Vidal S, Yung L, Saric M, Galloway A, Jilaihawi H, Attubato M, Fara M, Grossi E, Ischida K, Loulmet D, Siller K, Staniloae C, Torres J, Zhang C, Hartlev C, Huffman A, Jones D, Kellum A, Liptrot R, Orsinelli D, Ryan J, Ryan T, Crestanello J, George B, Lilly S, Rushing G, Grose N, Kilic A, Lee V, Mazzaferri E, Mutgi S, O'Neil S, Perchuk A, Sai-Sudhakar C, Slivka A, Cheatham J, Hanes S, Banowetz M, Dautenhahn D, Mehl B, Bodenhamer R, Ghani M, Raikar G, Randolph J, Tahirkheli N, Wasemiller W, Williams J, Amoroso E, Holt S, Tucker C, Martin R, Kauten J, Rajagopal V, Awad E, Brown W, Dean D, Gott J, Karmpaliotis D, Meduri C, Polsani V, Rinehart S, Russell C, Seiden L, Serbanescu A, Vannan M, Butler K, Elsessor K, Fehr B, Hancock A, Hollister R, MacFarlane D, Rodgers C, Todd A, Eubanks V, Spangler J, Wirt K, Wonders B, Bachinsky W, Gada H, Maini B, Mumtaz M, Aneja P, Loran D, Shah J, Gebhardt L, Jones U, Lauterborn M, John H, Parthier S, Schaprian K, Twelker K, Nickenig G, Welz A, Bode F, Fuchs A, Grube E, Mellert F, Petzold G, Sedaghat A, Sinning J, Vasa-Nicotera M, 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Brown D, Ryan W, Brinkman W, Gopal A, Harrington K, Mack M, Nosnik P, Potluri S, Smith R, Szerlip M, Blaylock C, Brinegar P, Canter L, Green L, Green L, Hazen P, Jacobs A, Khan S, Ludwig S, Mata M, Moore T, Underwood C, Faza N, Little S, Nagueh S, Kleiman N, Reardon M, Albright K, Atkins M, Barker C, Bledsoe D, Chiu D, Goel S, Gray T, Imperial-Aubin D, Lin C, Moye S, Ramchandani M, Ramlawi B, Reul R, Reyes M, Scheinin S, Volpi J, White S, Wyler von Ballmoos M, Blackburn B, Wong R, Hart C, Whitacker P, Lau J, Spies C, Badawi R, Graner S, Nakamura D, Plank B, Salem R, Seto T, Valenta D, Cruz A, Gallagher L, Schuck L, Siki M, Weeks A, Fishman L, Schwarz T, Bavaria J, Herrmann H, Anwaruddin S, Desai N, Giri J, Khella S, Li R, McGarvery M, Messe S, Price R, Quinn C, Szeto W, Vallabhajosyula P, Sun Y, Wu L, Tsang W, Thavendiranathan D, Feindel C, Horlick E, Casaubon L, Cusimano R, Del Campo M, Osten M, Silver F, Höwisch-Pengel R, Lechner G, Steiger B, Allgeier M, Jander N, Beyersdorf F, 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P, Nguyen P, Burdon T, Giacomini J, Yong C, Buchbinder M, Fann J, Kilgore S, Mitchell R, McDaniel S, Pack A, White W, Young T, Burgess P, Pu M, Upadhya B, Applegate R, Kon N, Arnan M, Baghshomali S, Bishop L, Bradbury E, Gandhi S, Kincaid E, Lefkowitz D, Lisle B, Batteria M, Rerisi E, Stepinowski K, Senicola T, Goncalves J, Schubach S, Schwartz R, Antaky K, Christiansen C, Marzo K, Michel K, Misra A, Varghese P, Wirkowski E, Levesque L, Sugeng L, Cleman M, Forrest J, Hashim S, Mangi A, Amin H, Darr U, Dewar M, Faheem O, Geirsson A, Greer D, Kaleel A, Kaple R, Lansky A, MacGrory B, Pfau S, Schindler J, Thompson C, Youn T, Yuh D, Yun J. Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients. JAMA Cardiology 2022, 7: 1000-1008. PMID: 36001335, PMCID: PMC9403849, DOI: 10.1001/jamacardio.2022.2695.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementSevere aortic valve stenosisIntermediate-risk patientsAortic valve stenosisValve replacementAdverse eventsAortic stenosisValve stenosisParavalvular leakClinical trialsIndependent echocardiographic core laboratorySurgical aortic valve replacementSymptomatic severe aortic stenosisIndependent clinical events committeePrespecified secondary end pointsEchocardiographic core laboratoryIntermediate surgical riskIntermediate-risk subjectsLocal heart teamSecondary end pointsSerious adverse eventsSevere aortic stenosisSymptomatic aortic stenosisAortic valve areaRandomized Trial of Chocolate Touch Compared With Lutonix Drug-Coated Balloon in Femoropopliteal Lesions (Chocolate Touch Study)
Shishehbor MH, Zeller T, Werner M, Brodmann M, Parise H, Holden A, Lichtenberg M, Parikh SA, Kashyap VS, Pietras C, Tirziu D, Ardakani S, Beschorner U, Krishnan P, Niazi KA, Wali AU, Lansky AJ. Randomized Trial of Chocolate Touch Compared With Lutonix Drug-Coated Balloon in Femoropopliteal Lesions (Chocolate Touch Study). Circulation 2022, 145: 1645-1654. PMID: 35377157, DOI: 10.1161/circulationaha.122.059646.Peer-Reviewed Original ResearchConceptsLutonix drug-coated balloonDrug-coated balloonsEnd pointPrimary efficacy end pointPrimary safety end pointIndependent clinical events committeeIschemic rest painPrimary efficacy rateEfficacy end pointPrimary end pointSafety end pointClinical events committeeMajor adverse eventsRate of restenosisDrug-Coated BalloonNoninferiority end pointSafety event rateAverage lesion lengthMajor amputationPopliteal diseaseRest painBailout stentingEfficacy ratePrimary patencyAdverse events
2021
Novel Supreme Drug-Eluting Stents With Early Synchronized Antiproliferative Drug Delivery to Inhibit Smooth Muscle Cell Proliferation After Drug-Eluting Stents Implantation in Coronary Artery Disease
Lansky AJ, Kereiakes DJ, Baumbach A, Windecker S, Hussain Y, Pietras C, Dressler O, Issever O, Curtis M, Bertolet B, Zidar JP, Smits PC, Díaz V, McLaurin B, Hofma S, Cequier Á, Dib N, Benit E, Mathur A, Brogno D, Berland J, Wykrzykowska J, Piegari G, Brugaletta S, Saito S, Leon MB, Investigators O. Novel Supreme Drug-Eluting Stents With Early Synchronized Antiproliferative Drug Delivery to Inhibit Smooth Muscle Cell Proliferation After Drug-Eluting Stents Implantation in Coronary Artery Disease. Circulation 2021, 143: 2143-2154. PMID: 33820424, DOI: 10.1161/circulationaha.120.052482.Peer-Reviewed Original ResearchConceptsDurable polymer everolimus-eluting stentsDrug-eluting stentsTarget lesion revascularizationAntiproliferative drug deliveryChronic coronary syndromeVessel myocardial infarctionLesion revascularizationCoronary syndromeLesion failureMyocardial infarctionDrug-Eluting Stent ImplantationTarget vessel myocardial infarctionLong-term clinical outcomesDP-EES groupPrimary end pointTarget lesion failureSmooth muscle cell proliferationPercutaneous coronary interventionSingle-blind trialCoronary artery diseaseEverolimus-eluting stentsMuscle cell proliferationLong-term inflammatory responseDrug eluting stentsCardiovascular deathAtrial fibrillation risk in patients suffering from type I diabetes mellitus. A review of clinical and experimental evidence
Vrachatis DA, Papathanasiou KA, Kossyvakis C, Giotaki SG, Raisakis K, Iliodromitis KE, Reimers B, Stefanini GG, Cleman M, Sianos G, Lansky A, Deftereos SG, Giannopoulos G. Atrial fibrillation risk in patients suffering from type I diabetes mellitus. A review of clinical and experimental evidence. Diabetes Research And Clinical Practice 2021, 174: 108724. PMID: 33647332, DOI: 10.1016/j.diabres.2021.108724.Peer-Reviewed Original ResearchConceptsDiabetes mellitusAtrial fibrillationType 1 diabetes mellitusIndependent risk factorAtrial fibrillation managementAtrial fibrillation riskAF developmentInsulin deficiencyGlycemic variabilityRisk factorsClinical dataClinical studiesMicrovascular sequelaeAtrial arrhythmogenesisAnimal studiesAtrial myocytesClinical practiceArrhythmia initiationStructural remodelingClinical implicationsT1DMOxidative stressPI3KGlucose transportationMellitusMeta-Analysis of Gender Disparities in In-hospital Care and Outcomes in Patients with ST-Segment Elevation Myocardial Infarction
Shah T, Haimi I, Yang Y, Gaston S, Taoutel R, Mehta S, Lee HJ, Zambahari R, Baumbach A, Henry TD, Grines CL, Lansky A, Tirziu D. Meta-Analysis of Gender Disparities in In-hospital Care and Outcomes in Patients with ST-Segment Elevation Myocardial Infarction. The American Journal Of Cardiology 2021, 147: 23-32. PMID: 33640366, DOI: 10.1016/j.amjcard.2021.02.015.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIMyocardial infarctionMajor bleedingBalloon timeST-segment elevation myocardial infarctionMyocardial infarction outcomesRepeat myocardial infarctionFirst medical contactElevation myocardial infarctionPercutaneous coronary interventionSpecific patient characteristicsRate of mortalityAspirin usageMore comorbiditiesAntiplatelet therapyHospital outcomesP2Y12 inhibitorsCoronary interventionLonger doorPatient characteristicsMedical contactClinical outcomesGender disparitiesSuboptimal treatment
2020
Safety and effectiveness of coronary intravascular lithotripsy in eccentric calcified coronary lesions: a patient-level pooled analysis from the Disrupt CAD I and CAD II Studies
Blachutzik F, Honton B, Escaned J, Hill JM, Werner N, Banning AP, Lansky AJ, Schlattner S, De Bruyne B, Di Mario C, Dörr O, Hamm C, Nef HM. Safety and effectiveness of coronary intravascular lithotripsy in eccentric calcified coronary lesions: a patient-level pooled analysis from the Disrupt CAD I and CAD II Studies. Clinical Research In Cardiology 2020, 110: 228-236. PMID: 32948882, PMCID: PMC7862504, DOI: 10.1007/s00392-020-01737-3.Peer-Reviewed Original ResearchConceptsCoronary intravascular lithotripsyIntravascular lithotripsyCalcified coronary lesionsII studyResidual stenosisCoronary lesionsCAD IPooled patient-level analysisFinal residual stenosisPercent residual stenosisFlow-limiting dissectionPatient-level analysisPatient-level dataHospital MACEIVL useAcute gainClinical outcomesConcentric lesionsEccentric lesionsCalcified lesionsAbrupt closureReflow eventsResultsClinical successStenosisConcentric stenosisCharacteristics of cardiac catheterization laboratory directors at the 2017 U.S. News & World Report top 100 U.S. cardiovascular hospitals
Murugiah K, Annapureddy AR, Khera R, Lansky A, Curtis JP. Characteristics of cardiac catheterization laboratory directors at the 2017 U.S. News & World Report top 100 U.S. cardiovascular hospitals. Catheterization And Cardiovascular Interventions 2020, 97: e624-e626. PMID: 32833350, DOI: 10.1002/ccd.29217.Peer-Reviewed Original ResearchConceptsCardiac catheterization laboratoryCardiovascular HospitalFellowship trainingPercutaneous coronary interventionCardiac catheterization laboratory directorsStructural interventionsCoronary interventionMedian agePeripheral interventionsMedical school graduationCardiovascular programCatheterization laboratoryMedicare dataMedicare Provider UtilizationHospitalClinical focusMedian yearsProvider UtilizationFrequency of Management of Cardiogenic Shock With Mechanical Circulatory Support Devices According to Race
Kim Y, Park J, Essa M, Lansky AJ, Sugeng L. Frequency of Management of Cardiogenic Shock With Mechanical Circulatory Support Devices According to Race. The American Journal Of Cardiology 2020, 125: 1782-1787. PMID: 32471549, DOI: 10.1016/j.amjcard.2020.03.025.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMechanical circulatory supportCardiogenic shockNational Inpatient SampleHospital mortalityBlack patientsInpatient SampleMCS devicesPopulation-based retrospective cohort studyMCS utilizationMechanical circulatory support devicesOnly black patientsRetrospective cohort studyClinical Modification codesMultivariate logistic regressionCirculatory support devicesAcute clinical scenariosHospital outcomesCohort studyPrimary outcomeClinical outcomesHospital eventsCirculatory supportNinth RevisionMyocardial infarctionIntravascular Lithotripsy for Treatment of Calcified Lower Extremity Arterial Stenosis: Initial Analysis of the Disrupt PAD III Study
Adams G, Shammas N, Mangalmurti S, Bernardo NL, Miller WE, Soukas PA, Parikh SA, Armstrong EJ, Tepe G, Lansky A, Gray WA. Intravascular Lithotripsy for Treatment of Calcified Lower Extremity Arterial Stenosis: Initial Analysis of the Disrupt PAD III Study. Journal Of Endovascular Therapy 2020, 27: 473-480. PMID: 32242768, PMCID: PMC7288854, DOI: 10.1177/1526602820914598.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePeripheral intravascular lithotripsyIntravascular lithotripsyResidual stenosisAcute gainObservational studyChronic limb-threatening ischemiaSingle-arm observational studyBalloon-based technologiesHigher acute gainMean residual stenosisLimb-threatening ischemiaLower limb arteriesEnd of procedureSevere arterial calcificationLow residual stenosisReal-world studyAngiographic complicationsDistal embolizationHospital dischargeIII studyArtery diseaseThrombotic eventsEndovascular treatmentLimb arteriesPredictive value of the QFR in detecting vulnerable plaques in non-flow limiting lesions: a combined analysis of the PROSPECT and IBIS-4 study
Safi H, Bourantas CV, Ramasamy A, Zanchin T, Bär S, Tufaro V, Jin C, Torii R, Karagiannis A, Reiber JHC, Mathur A, Onuma Y, Windecker S, Lansky A, Maehara A, Serruys PW, Stone P, Baumbach A, Stone GW, Räber L. Predictive value of the QFR in detecting vulnerable plaques in non-flow limiting lesions: a combined analysis of the PROSPECT and IBIS-4 study. The International Journal Of Cardiovascular Imaging 2020, 36: 993-1002. PMID: 32152810, DOI: 10.1007/s10554-020-01805-9.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary AngiographyCoronary Artery DiseaseCoronary CirculationCoronary VesselsDisease ProgressionFemaleHumansMaleMiddle AgedPlaque, AtheroscleroticPredictive Value of TestsPrognosisRadiographic Image Interpretation, Computer-AssistedRetrospective StudiesRupture, SpontaneousSeverity of Illness IndexTime FactorsUltrasonography, InterventionalConceptsVirtual histology intravascular ultrasoundQuantitative flow ratioMinimum lumen diameterMinimum lumen areaCoronary angiographyPlaque burdenIBIS-4 studyPrognostic informationVulnerable plaquesSmaller minimum lumen areaMajor adverse cardiac eventsVulnerable phenotypeAdverse cardiac eventsGreater plaque burdenPredictors of MACENon-culprit lesionsAdditional prognostic informationSmaller minimum lumen diameterUseful prognostic informationQuantitative coronary angiographyAdditive valueCardiac eventsPlaque characteristicsLesion severityAngiographic data
2019
First-in-Human Study of Paclitaxel Drug-Coated Chocolate Coronary Percutaneous Transluminal Coronary Angioplasty Balloon Catheter in De Novo Coronary Artery Lesions
Garcia-Lithgow C, Tirziu D, Zhou S, Bouras G, Shah T, Grubman D, Javier JJ, Mustapha JA, Abizaid A, Lansky AJ. First-in-Human Study of Paclitaxel Drug-Coated Chocolate Coronary Percutaneous Transluminal Coronary Angioplasty Balloon Catheter in De Novo Coronary Artery Lesions. JACC Cardiovascular Interventions 2019, 12: 2568-2570. PMID: 31857033, DOI: 10.1016/j.jcin.2019.08.044.Peer-Reviewed Original ResearchTreating Post-Angioplasty Dissection in the Femoropopliteal Arteries Using the Tack Endovascular System 12-Month Results From the TOBA II Study
Gray WA, Cardenas JA, Brodmann M, Werner M, Bernardo NI, George JC, Lansky A. Treating Post-Angioplasty Dissection in the Femoropopliteal Arteries Using the Tack Endovascular System 12-Month Results From the TOBA II Study. JACC Cardiovascular Interventions 2019, 12: 2375-2384. PMID: 31806218, DOI: 10.1016/j.jcin.2019.08.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, BalloonBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationEuropeFemaleFemoral ArteryHumansMaleMiddle AgedPeripheral Arterial DiseasePopliteal ArteryProspective StudiesProsthesis DesignRisk FactorsStentsTime FactorsTreatment OutcomeUnited StatesVascular Access DevicesVascular PatencyVascular System InjuriesConceptsProximal popliteal arteryDrug-coated balloonsSuperficial femoral arteryPlain balloonPopliteal arteryFemoral arteryTack Endovascular SystemLong-term outcomesDCB angioplastyEfficacy endpointPrimary patencyResidual stenosisRestenotic lesionsMulticenter studyFemoropopliteal arteriesEndovascular SystemAngioplastyArteryClassification 2DissectionLesionsBalloonStenosisPatencyPatientsValidation of the all-comers design: Results of the TARGET-AC substudy
G Toth G, Lansky A, Baumbach A, Kelbæk H, van Royen N, Holmvang L, Janssens L, Brugaletta S, Barbato E, Maillard L, Kiemeneij F, Naber CK, Pucher F, Laursen PN, Ameloot K, Robles C, Milkas A, Sevilla J, Jensen C, Wijns W. Validation of the all-comers design: Results of the TARGET-AC substudy. American Heart Journal 2019, 221: 148-154. PMID: 31924299, DOI: 10.1016/j.ahj.2019.10.019.Peer-Reviewed Original ResearchConceptsComers designRisk factorsNon-ST elevation acute coronary syndromeElevation acute coronary syndromeNER groupReal-world clinical practiceGroup more patientsInternational multicentre registrySignificant valvular diseaseST-elevation infarctionAcute coronary syndromeChronic total occlusionWorld clinical practiceLow inclusion rateMulticentre registryThrombotic stenosisCoronary syndromePrimary PCIStable anginaAngiographic parametersComers populationPatient demographicsStable patientsStudy nursesMore patientsClinical outcomes of complex lesions treated with an abluminal groove‐filled biodegradable polymer sirolimus‐eluting stent and durable polymer everolimus‐eluting stent
Saito Y, Baumbach A, Wijns W, Xu B, Kelbæk H, Zheng M, Morel M, Anderson R, Schächinger V, Lansky A, Investigators T. Clinical outcomes of complex lesions treated with an abluminal groove‐filled biodegradable polymer sirolimus‐eluting stent and durable polymer everolimus‐eluting stent. Catheterization And Cardiovascular Interventions 2019, 96: 1023-1028. PMID: 31769161, DOI: 10.1002/ccd.28609.Peer-Reviewed Original ResearchConceptsHigh-risk patientsClinical outcomesComer studyI trialDurable polymer everolimus-eluting stentsTarget vessel myocardial infarctionSirolimus-eluting coronary stentYear clinical outcomesTarget lesion failureVessel myocardial infarctionLow-risk patientsWorse clinical outcomesEverolimus-eluting stentsHigh-risk groupLow-risk groupStrict eligibility criteriaFIREHAWK stentLesion failurePrimary endpointRandomized trialsMyocardial infarctionRisk groupsInclusion criteriaComplex lesionsXIENCE stentSafety and Effectiveness of Coronary Intravascular Lithotripsy for Treatment of Severely Calcified Coronary Stenoses
Ali ZA, Nef H, Escaned J, Werner N, Banning AP, Hill JM, De Bruyne B, Montorfano M, Lefevre T, Stone GW, Crowley A, Matsumura M, Maehara A, Lansky AJ, Fajadet J, Di Mario C. Safety and Effectiveness of Coronary Intravascular Lithotripsy for Treatment of Severely Calcified Coronary Stenoses. Circulation Cardiovascular Interventions 2019, 12: e008434. PMID: 31553205, DOI: 10.1161/circinterventions.119.008434.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac CatheterizationCoronary AngiographyCoronary StenosisEuropeFemaleHumansLithotripsyMaleMiddle AgedPatient SafetyPercutaneous Coronary InterventionProspective StudiesRisk FactorsSeverity of Illness IndexStentsTime FactorsTomography, Optical CoherenceTreatment OutcomeUnited StatesVascular CalcificationConceptsSevere coronary artery calcificationCoronary artery calcificationMajor adverse cardiac eventsAdverse cardiac eventsPrimary end pointIntravascular lithotripsyOptical coherence tomographyCardiac eventsStent implantationPlaque fractureHospital major adverse cardiac eventsNon-Q-wave myocardial infarctionOptical coherence tomography substudyIndependent clinical events committeeCoherence tomographyDrug-eluting stent implantationEnd pointCoronary intravascular lithotripsyClinical events committeeHigh procedural successIndependent core laboratoryAcute luminal gainPost-approval studiesMechanism of actionCalcium fractureEvaluation of anticoagulant and antiplatelet therapy after iliocaval stenting: Factors associated with stent occlusion
Attaran RR, Ozdemir D, Lin IH, Mena-Hurtado C, Lansky A. Evaluation of anticoagulant and antiplatelet therapy after iliocaval stenting: Factors associated with stent occlusion. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2019, 7: 527-534. PMID: 31203859, DOI: 10.1016/j.jvsv.2019.01.058.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnticoagulantsEndovascular ProceduresFemaleHumansIliac VeinMaleMay-Thurner SyndromeMiddle AgedPlatelet Aggregation InhibitorsPostthrombotic SyndromeProsthesis DesignRecurrenceRetrospective StudiesStentsTime FactorsTreatment OutcomeVascular PatencyVena Cava, InferiorVenous ThrombosisConceptsAcute deep vein thrombosisPost-thrombotic syndromeDeep vein thrombosisMay-Thurner syndromeDuration of anticoagulationAntiplatelet therapyPatency ratesIliocaval stentingIpsilateral deep vein thrombosisIliocaval venous stentingPrimary patency rateStent patency ratesCommon femoral veinVariety of indicationsLarge teaching hospitalVein thrombosisVenous stentingRetrospective reviewDVT groupStent groupFemoral veinProcedural dataStent patencyStent occlusionTeaching hospital2-Year Clinical Outcomes of an Abluminal Groove–Filled Biodegradable-Polymer Sirolimus-Eluting Stent Compared With a Durable-Polymer Everolimus-Eluting Stent
Xu B, Saito Y, Baumbach A, Kelbæk H, van Royen N, Zheng M, Morel MA, Knaapen P, Slagboom T, Johnson TW, Vlachojannis G, Arkenbout KE, Holmvang L, Janssens L, Ochala A, Brugaletta S, Naber CK, Anderson R, Rittger H, Berti S, Barbato E, Toth GG, Maillard L, Valina C, Buszman P, Thiele H, Schächinger V, Lansky A, Wijns W, Investigators T. 2-Year Clinical Outcomes of an Abluminal Groove–Filled Biodegradable-Polymer Sirolimus-Eluting Stent Compared With a Durable-Polymer Everolimus-Eluting Stent. JACC Cardiovascular Interventions 2019, 12: 1679-1687. PMID: 31129092, DOI: 10.1016/j.jcin.2019.05.001.Peer-Reviewed Original ResearchMeSH KeywordsAbsorbable ImplantsAgedCardiovascular AgentsCoronary Artery DiseaseCoronary ThrombosisDrug-Eluting StentsDual Anti-Platelet TherapyEuropeEverolimusFemaleHumansMaleMiddle AgedPercutaneous Coronary InterventionPolymersProspective StudiesProsthesis DesignRisk FactorsSirolimusTime FactorsTreatment OutcomeConceptsTarget lesion failureXIENCE stentXience groupLesion failurePrimary endpointClinical outcomesIschemia-driven target lesion revascularizationTarget vessel myocardial infarctionProbable stent thrombosisTarget lesion revascularizationVessel myocardial infarctionLong-term outcomesDurable polymer everolimusBiodegradable Polymer SirolimusAbluminal grooveFIREHAWK stentLesion revascularizationCardiac deathComparable safetyStent thrombosisMyocardial infarctionClinical trialsEfficacy profileNoninferiority trialLandmark analysisBalloon-Expandable Vascular Covered Stent in the Treatment of Iliac Artery Occlusive Disease: 9-Month Results from the BOLSTER Multicenter Study
Laird JR, Zeller T, Holden A, Scheinert D, Moore E, Mendes R, Schmiedel R, Settlage R, Lansky A, Jaff MR, Investigators B, Elmasri F, Robinson W, Beasley R, Mego D, Marica S, Bersin R, Kujath S, Razavi M, Teßarek J, Schulte K. Balloon-Expandable Vascular Covered Stent in the Treatment of Iliac Artery Occlusive Disease: 9-Month Results from the BOLSTER Multicenter Study. Journal Of Vascular And Interventional Radiology 2019, 30: 836-844.e1. PMID: 30956077, DOI: 10.1016/j.jvir.2018.12.031.Peer-Reviewed Original ResearchConceptsMajor adverse eventsWalking Impairment QuestionnaireQuality of lifeLesion revascularizationPrimary patencyMyocardial infarctionIliac artery occlusive diseaseComposite endpoint rateProcedure-related deathsTarget lesion revascularizationArtery occlusive diseaseSingle-arm studyMajor amputationRutherford categoryOcclusive lesionsPrimary endpointSecondary endpointsAdverse eventsClinical improvementImpairment QuestionnaireOcclusive diseaseClinical outcomesMulticenter studyEndpoint rateIliac artery