2013
The impact of the coronary collateral circulation on outcomes in patients with acute coronary syndromes: results from the ACUITY trial
Meier P, Lansky AJ, Fahy M, Xu K, White HD, Bertrand ME, Mehran R, Stone GW. The impact of the coronary collateral circulation on outcomes in patients with acute coronary syndromes: results from the ACUITY trial. Heart 2013, 100: 647. PMID: 24310521, DOI: 10.1136/heartjnl-2013-304435.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedCollateral CirculationCoronary AngiographyCoronary Artery BypassCoronary CirculationFemaleFibrinolytic AgentsHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPercutaneous Coronary InterventionPredictive Value of TestsProportional Hazards ModelsRisk FactorsTime FactorsTreatment OutcomeConceptsMajor adverse cardiac eventsAcute coronary syndromeTarget vessel revascularisationPercutaneous coronary interventionAdverse cardiac eventsCoronary collateral circulationMyocardial infarctionCoronary syndromeCardiac eventsClinical outcomesCollateral circulationHigh-risk acute coronary syndromesUrgent Intervention Triage Strategy (ACUITY) trialIndependent angiographic core laboratorySubgroup of patientsCoronary collateral vesselsAngiographic core laboratoryPresence of collateralsACUITY trialAcute CatheterizationRentrop scoreVessel revascularisationMultivariable adjustmentCoronary interventionVisible collaterals
2012
Refining the Role of Antiplatelet Therapy in Medically Managed Patients With Acute Coronary Syndrome
Boden WE, Lansky A, Angiolillo DJ. Refining the Role of Antiplatelet Therapy in Medically Managed Patients With Acute Coronary Syndrome. The American Journal Of Cardiology 2012, 111: 439-444. PMID: 23168289, DOI: 10.1016/j.amjcard.2012.10.018.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeDual antiplatelet therapyAntiplatelet therapyCoronary syndromeHigh-risk percutaneous coronary interventionUnmet needPotent platelet inhibitionChronic kidney diseaseComplex coronary anatomyFirst-line therapyHigh-risk patientsLow-risk patientsPercutaneous coronary interventionSubgroup of patientsPrevious revascularizationPharmacologic managementCoronary interventionRisk patientsDiabetes mellitusPlatelet inhibitionSuch patientsCoronary anatomyKidney diseaseTherapeutic optionsTreatment optionsCoronary collaterals and risk for restenosis after percutaneous coronary interventions: a meta-analysis
Meier P, Indermuehle A, Pitt B, Traupe T, de Marchi SF, Crake T, Knapp G, Lansky AJ, Seiler C. Coronary collaterals and risk for restenosis after percutaneous coronary interventions: a meta-analysis. BMC Medicine 2012, 10: 62. PMID: 22720974, PMCID: PMC3386894, DOI: 10.1186/1741-7015-10-62.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionCoronary collateral circulationCoronary artery diseaseRisk ratioCoronary interventionCollateral circulationGood collateralizationCoronary collateralsStable coronary artery diseaseGood coronary collateralizationSummary risk ratiosSubgroup of patientsAcute myocardial infarctionRisk of restenosisIntracoronary pressure measurementsRandom-effects modelPoor collateralsAngiographic restenosisPrimary endpointArtery diseaseCoronary collateralizationRisk stratificationResultsA totalMyocardial infarctionSubgroup analysis
2011
Prognostic Impact of Staged Versus “One-Time” Multivessel Percutaneous Intervention in Acute Myocardial Infarction Analysis From the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial
Kornowski R, Mehran R, Dangas G, Nikolsky E, Assali A, Claessen BE, Gersh BJ, Wong SC, Witzenbichler B, Guagliumi G, Dudek D, Fahy M, Lansky AJ, Stone GW, Investigators H. Prognostic Impact of Staged Versus “One-Time” Multivessel Percutaneous Intervention in Acute Myocardial Infarction Analysis From the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial. Journal Of The American College Of Cardiology 2011, 58: 704-711. PMID: 21816305, DOI: 10.1016/j.jacc.2011.02.071.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-segment elevation myocardial infarctionMultivessel primary percutaneous coronary interventionMajor adverse cardiovascular eventsHORIZONS-AMI trialAdverse cardiovascular eventsMultivessel diseaseNonculprit lesionsCardiovascular eventsStent thrombosisPCI strategyPrimary PCIAcute Myocardial Infarction AnalysisProbable stent thrombosisTarget vessel revascularizationElevation myocardial infarctionPercutaneous coronary interventionSubgroup of patientsPrimary PCI proceduresMultivessel percutaneous interventionNonculprit vesselsCardiac mortalityCause mortalityCulprit lesionSTEMI patientsImpact of Leukocyte Count on Mortality and Bleeding in Patients With Myocardial Infarction Undergoing Primary Percutaneous Coronary Interventions
Palmerini T, Mehran R, Dangas G, Nikolsky E, Witzenbichler B, Guagliumi G, Dudek D, Genereux P, Caixeta A, Rabbani L, Weisz G, Parise H, Fahy M, Xu K, Brodie B, Lansky A, Stone GW. Impact of Leukocyte Count on Mortality and Bleeding in Patients With Myocardial Infarction Undergoing Primary Percutaneous Coronary Interventions. Circulation 2011, 123: 2829-2837. PMID: 21632496, DOI: 10.1161/circulationaha.110.985564.Peer-Reviewed Original ResearchConceptsWhite blood cell countPeak creatinine phosphokinase levelCreatinine phosphokinase levelsPercutaneous coronary interventionST-segment elevation acute myocardial infarctionBaseline white blood cell countCoronary interventionAcute myocardial infarctionIndependent predictorsNoncardiac mortalityCardiac mortalityMyocardial infarctionMajor bleedingHigher white blood cell countLower white blood cell countPropensity-adjusted multivariable analysisAcute Myocardial Infarction trialPrimary percutaneous coronary interventionMyocardial Infarction trialVentricular ejection fractionSubgroup of patientsBlood cell countHarmonizing OutcomesCause mortalityEjection fraction
2010
Everolimus-Eluting versus Paclitaxel-Eluting Stents in Coronary Artery Disease
Stone GW, Rizvi A, Newman W, Mastali K, Wang JC, Caputo R, Doostzadeh J, Cao S, Simonton CA, Sudhir K, Lansky AJ, Cutlip DE, Kereiakes DJ. Everolimus-Eluting versus Paclitaxel-Eluting Stents in Coronary Artery Disease. New England Journal Of Medicine 2010, 362: 1663-1674. PMID: 20445180, DOI: 10.1056/nejmoa0910496.Peer-Reviewed Original ResearchConceptsPaclitaxel-eluting stentsTarget lesion failureEverolimus-eluting stentsMajor secondary end pointPrimary end pointSecondary end pointsEnd pointMyocardial infarctionIschemia-driven target lesion revascularizationRoutine follow-up angiographyTarget vessel myocardial infarctionComposite rateTarget lesion revascularizationClinical end pointsCoronary artery diseaseSubgroup of patientsFollow-up angiographyEverolimus-ElutingAngiographic findingsPrespecified subgroupsArtery diseaseCardiac deathStent thrombosisPatientsStents
2004
Minimally invasive coronary artery bypass grafting versus stenting for patients with proximal left anterior descending coronary artery disease
Shirai K, Lansky AJ, Mehran R, Dangas GD, Costantini CO, Fahy M, Slack S, Mintz GS, Stone GW, Leon MB. Minimally invasive coronary artery bypass grafting versus stenting for patients with proximal left anterior descending coronary artery disease. The American Journal Of Cardiology 2004, 93: 959-962. PMID: 15081435, DOI: 10.1016/j.amjcard.2003.12.048.Peer-Reviewed Original ResearchConceptsCoronary artery bypassInvasive coronary artery bypassLAD stentingCoronary artery diseaseArtery bypassArtery diseaseClinical outcomesAnterior descending (LAD) coronary artery diseaseConventional coronary artery bypassHigher repeat revascularization ratesQ-wave myocardial infarctionHospital event ratesProximal LAD diseaseRepeat revascularization rateShorter hospital staySubgroup of patientsConventional balloon angioplastyIncidence of deathLong-term efficacyLAD revascularizationMIDCAB groupHospital stayLAD diseaseRevascularization ratesVessel revascularization
2001
Comparison of self-expanding and balloon-expandable stents for the reduction of restenosis
Han R, Schwartz R, Kobayashi Y, Wilson S, Mann J, Sketch M, Safian R, Lansky A, Popma J, Fitzgerald P, Palacios I, Chazin-Caldie M, Goldberg S, in the Appendix. F. Comparison of self-expanding and balloon-expandable stents for the reduction of restenosis. The American Journal Of Cardiology 2001, 88: 253-259. PMID: 11472703, DOI: 10.1016/s0002-9149(01)01636-8.Peer-Reviewed Original ResearchConceptsNative coronary arteriesIntravascular ultrasound examinationBalloon-expandable stentsSE stentsCoronary arteryBE stentsMajor adverse cardiac eventsAdverse cardiac eventsBinary restenosis rateCoronary angiographic characteristicsSubgroup of patientsMinimum stent areaReduction of restenosisAngiographic characteristicsAngiographic outcomesBaseline demographicsBypass surgeryCardiac eventsRestenosis rateRestenotic lesionsIntimal proliferationIVUS analysisMyocardial infarctionUltrasound examinationLate loss