2016
Impact of gender on infarct size, ST-segment resolution, myocardial blush and clinical outcomes after primary stenting for acute myocardial infarction: Substudy from the EMERALD trial
Ng VG, Mori K, Costa RA, Kish M, Mehran R, Urata H, Saku K, Stone GW, Lansky AJ. Impact of gender on infarct size, ST-segment resolution, myocardial blush and clinical outcomes after primary stenting for acute myocardial infarction: Substudy from the EMERALD trial. International Journal Of Cardiology 2016, 207: 269-276. PMID: 26808991, DOI: 10.1016/j.ijcard.2016.01.013.Peer-Reviewed Original ResearchConceptsPrimary percutaneous interventionAcute myocardial infarctionST-segment resolutionInfarct sizeMyocardial infarctionST-segment elevation acute myocardial infarctionPrimary PCIPrior acute myocardial infarctionElevation acute myocardial infarctionComplete ST resolutionSmaller infarct sizeDistal protection devicesSmall vessel sizeGender-specific factorsDistal protectionEMERALD trialLAD infarctsMore hypertensionWorse comorbiditiesMidterm outcomesPrimary stentingSegment resolutionAMI patientsClinical outcomesST resolution
2013
Impact of bifurcation target lesion on angiographic, electrocardiographic, and clinical outcomes of patients undergoing primary percutaneous coronary intervention (from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction [HORIZONS-AMI] trial).
Dudek D, Mehran R, Dziewierz A, Brener SJ, Rakowski T, Brzezinski M, Brodie BR, Xu K, Fahy M, Lansky AJ, Zmudka K, Stone GW. Impact of bifurcation target lesion on angiographic, electrocardiographic, and clinical outcomes of patients undergoing primary percutaneous coronary intervention (from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction [HORIZONS-AMI] trial). EuroIntervention 2013, 9: 817-23. PMID: 24280158, DOI: 10.4244/eijv9i7a135.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPercutaneous coronary interventionPrimary percutaneous coronary interventionCoronary interventionClinical outcomesTarget lesionsLow left ventricular ejection fractionPost-percutaneous coronary interventionLeft ventricular ejection fractionCore laboratory assessmentHigher contrast loadHORIZONS-AMI trialTarget vessel revascularisationProbable stent thrombosisST-segment resolutionElevation myocardial infarctionVentricular ejection fractionCore laboratory analysisRate of deathBTL groupHORIZONS-AMIVessel revascularisationInfarct arteryBaseline characteristicsContrast loadComplementary prognostic utility of myocardial blush grade and ST-segment resolution after primary percutaneous coronary intervention: Analysis from the HORIZONS-AMI trial
Brener SJ, Dizon JM, Mehran R, Guerchicoff A, Lansky AJ, Farkouh M, Brodie B, Guagliumi G, Witzenbichler B, Fahy M, Parise H, Stone GW. Complementary prognostic utility of myocardial blush grade and ST-segment resolution after primary percutaneous coronary intervention: Analysis from the HORIZONS-AMI trial. American Heart Journal 2013, 166: 676-683. PMID: 24093847, DOI: 10.1016/j.ahj.2013.07.025.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionST-segment resolutionMyocardial blush gradePrimary PCIPercutaneous coronary interventionBlush gradeHORIZONS-AMIMBG 2/3Coronary interventionPrognostic utilityMajor adverse cardiac eventsMyocardial blush grade 2/3ST-elevation myocardial infarctionHORIZONS-AMI trialAdverse cardiac eventsPredictors of deathIndependent prognostic significanceComplementary prognostic informationLong-term outcomesLong-term survivalCardiac eventsReperfusion successIndependent predictorsGrade 2/3Multivariable analysisRelationship Between ST-Segment Recovery and Clinical Outcomes After Primary Percutaneous Coronary Intervention
Farkouh ME, Reiffel J, Dressler O, Nikolsky E, Parise H, Cristea E, Baran DA, Dizon J, Merab JP, Lansky AJ, Mehran R, Stone GW. Relationship Between ST-Segment Recovery and Clinical Outcomes After Primary Percutaneous Coronary Intervention. Circulation Cardiovascular Interventions 2013, 6: 216-223. PMID: 23652600, DOI: 10.1161/circinterventions.112.000142.Peer-Reviewed Original ResearchMeSH KeywordsAgedChi-Square DistributionCoronary AngiographyElectrocardiographyFemaleFibrinolytic AgentsHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsProportional Hazards ModelsRecovery of FunctionRisk FactorsStentsTime FactorsTreatment OutcomeConceptsPrimary percutaneous coronary interventionST-segment elevation myocardial infarctionPrimary PCIMajor adverse cardiovascular eventsST-segment resolutionAdverse cardiovascular eventsIschemia-driven target vessel revascularizationComplete ST-segment resolutionTarget vessel revascularizationPercutaneous coronary interventionMyocardial infarctionCardiovascular eventsVessel revascularizationCoronary interventionIndependent predictorsDegree of STRBaseline ST-segment elevationAcute Myocardial Infarction trialLong-term prognostic valueLong-term cardiovascular mortalityLeft ventricular ejection fractionLong-term predictive valuePost-PCI electrocardiogramsMyocardial infarction (TIMI) flowMyocardial Infarction trial
2011
Comparison of Direct Stenting With Conventional Stent Implantation in Acute Myocardial Infarction
Möckel M, Vollert J, Lansky AJ, Witzenbichler B, Guagliumi G, Peruga JZ, Brodie BR, Kornowski R, Dudek D, Farkouh ME, Parise H, Mehran R, Stone GW, Investigators H. Comparison of Direct Stenting With Conventional Stent Implantation in Acute Myocardial Infarction. The American Journal Of Cardiology 2011, 108: 1697-1703. PMID: 21906709, DOI: 10.1016/j.amjcard.2011.07.040.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionElevation myocardial infarctionPercutaneous coronary interventionDirect stentingMyocardial infarctionCoronary interventionStent implantationConventional stentingPropensity score-based analysisAcute Myocardial Infarction trialDirect stenting groupMyocardial Infarction trialST-segment resolutionTarget lesion revascularizationPresent study cohortAcute myocardial infarctionScore-based analysisConventional stent implantationPropensity-score matchingCause deathHarmonizing OutcomesLesion revascularizationMajor bleedingStenting groupRationale and design of the INFUSE-AMI study: A 2 × 2 factorial, randomized, multicenter, single-blind evaluation of intracoronary abciximab infusion and aspiration thrombectomy in patients undergoing percutaneous coronary intervention for anterior ST-segment elevation myocardial infarction
Gibson CM, Maehara A, Lansky AJ, Wohrle J, Stuckey T, Dave R, Cox D, Grines C, Dudek D, Steg G, Parise H, Wolff SD, Cristea E, Stone GW. Rationale and design of the INFUSE-AMI study: A 2 × 2 factorial, randomized, multicenter, single-blind evaluation of intracoronary abciximab infusion and aspiration thrombectomy in patients undergoing percutaneous coronary intervention for anterior ST-segment elevation myocardial infarction. American Heart Journal 2011, 161: 478-486.e7. PMID: 21392601, DOI: 10.1016/j.ahj.2010.10.006.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAngioplasty, Balloon, CoronaryAntibodies, MonoclonalAntithrombinsCoronary OcclusionCoronary ThrombosisEndpoint DeterminationHirudinsHumansImmunoglobulin Fab FragmentsInfusions, Intra-ArterialMagnetic Resonance Imaging, CineMyocardial InfarctionPatient SelectionPeptide FragmentsPlatelet Aggregation InhibitorsRecombinant ProteinsResearch DesignThrombectomyConceptsPrimary percutaneous coronary interventionST-elevation myocardial infarctionPrimary PCIAnterior ST-elevation myocardial infarctionExport aspiration catheterPercutaneous coronary interventionLocal infusionThrombus aspirationInfarct sizeINFUSE-AMIEnd pointCoronary interventionAspiration catheterMyocardial infarctionInfusion catheterAnterior ST-segment elevation myocardial infarctionST-segment elevation myocardial infarctionSingle-blind randomized studyCardiac magnetic resonance imagingMyocardial infarction 0Mid-left anteriorPrimary end pointSafety end pointSecondary end pointsST-segment resolution
2009
Correlations between epicardial flow, microvascular reperfusion, infarct size and clinical outcomes in patients with anterior versus non-anterior myocardial infarction treated with primary or rescue angioplasty: analysis from the EMERALD trial.
Nikolsky E, Stone GW, Lee E, Lansky AJ, Webb J, Cox DA, Brodie BR, Turco MA, Rutherford BD, Kalynych AM, Antoniucci D, Krucoff MW, Gibbons RJ, Fahy M, Mehran R. Correlations between epicardial flow, microvascular reperfusion, infarct size and clinical outcomes in patients with anterior versus non-anterior myocardial infarction treated with primary or rescue angioplasty: analysis from the EMERALD trial. EuroIntervention 2009, 5: 417-24. PMID: 19755327, DOI: 10.4244/eijv5i4a66.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplastyAngioplasty, Balloon, CoronaryBlood PressureBradycardiaFemaleHumansMaleMiddle AgedMulticenter Studies as TopicMyocardial InfarctionPostoperative ComplicationsRandomized Controlled Trials as TopicStentsSurvival AnalysisSurvivorsTachycardiaTreatment FailureTreatment OutcomeConceptsAcute myocardial infarctionMicrovascular reperfusionInfarct sizeClinical outcomesMyocardial infarctionEMERALD trialLAD infarctsDistal protectionGrade 3Final TIMI flow grade 3Myocardial blush grade 3Non-anterior myocardial infarctionTIMI flow grade 3ST-segment resolutionEvent-free survivalInfarct-related arteryLarger infarct sizeSevere heart failureRate of reperfusionRescue angioplastyCulprit vesselPrimary PCIReperfusion successEpicardial flowHeart failure
2008
Contemporary outcomes of rescue percutaneous coronary intervention for acute myocardial infarction: Comparison with primary angioplasty and the role of distal protection devices (EMERALD trial)
Dangas G, Stone GW, Weinberg MD, Webb J, Cox DA, Brodie BR, Krucoff MW, Gibbons RJ, Lansky AJ, Mehran R, Investigators F. Contemporary outcomes of rescue percutaneous coronary intervention for acute myocardial infarction: Comparison with primary angioplasty and the role of distal protection devices (EMERALD trial). American Heart Journal 2008, 155: 1090-1096. PMID: 18513524, DOI: 10.1016/j.ahj.2007.12.003.Peer-Reviewed Original ResearchConceptsST-segment resolutionTIMI 3 flowDistal protection devicesPrimary PCIDistal protectionInfarct sizeRescue PCIPost-procedural TIMI 3 flowRescue percutaneous coronary interventionComplete ST-segment resolutionSimilar myocardial perfusionPercutaneous coronary interventionST-elevation MIAcute myocardial infarctionHigher baseline ratesPrespecified comparisonPCI patientsPrimary angioplastyMonth mortalityPrimary endpointCoronary interventionClinical outcomesMulticenter trialClinical eventsPatient population
2006
Relationship between infarct artery location, epicardial flow, and myocardial perfusion after primary percutaneous revascularization in acute myocardial infarction
Kandzari DE, Tcheng JE, Gersh BJ, Cox DA, Stuckey T, Turco M, Mehran R, Garcia E, Zimetbaum P, McGlaughlin MG, Lansky AJ, Costantini CO, Grines CL, Stone GW, Investigators F. Relationship between infarct artery location, epicardial flow, and myocardial perfusion after primary percutaneous revascularization in acute myocardial infarction. American Heart Journal 2006, 151: 1288-1295. PMID: 16781238, DOI: 10.1016/j.ahj.2005.08.017.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionAcute myocardial infarctionPrimary PCIST-segment resolutionMyocardial infarctionReperfusion successVentricular functionClinical outcomesCollateral flowAnterior infarctionMyocardial perfusionArtery locationFinal TIMI 3 flowIschemic target vessel revascularizationMajor adverse cardiac eventsReduced left ventricular functionRight coronary artery distributionPrimary percutaneous revascularizationAdverse cardiac eventsBaseline clinical characteristicsTarget vessel revascularizationTIMI 3 flowMyocardial blush gradePowerful independent predictorPercutaneous coronary interventionImpact of treatment delays on outcomes of primary percutaneous coronary intervention for acute myocardial infarction: Analysis from the CADILLAC trial
Brodie BR, Stone GW, Cox DA, Stuckey TD, Turco M, Tcheng JE, Berger P, Mehran R, McLaughlin M, Costantini C, Lansky AJ, Grines CL. Impact of treatment delays on outcomes of primary percutaneous coronary intervention for acute myocardial infarction: Analysis from the CADILLAC trial. American Heart Journal 2006, 151: 1231-1238. PMID: 16781224, DOI: 10.1016/j.ahj.2005.07.016.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPercutaneous coronary interventionAcute myocardial infarctionLow-risk patientsLeft ventricular functionOnset of symptomsTreatment delayCoronary interventionEarly reperfusionMyocardial infarctionCADILLAC trialVentricular functionComplete ST-segment resolutionPercutaneous transluminal coronary angioplastyFrequent grade 2ST-segment resolutionHigh-risk patientsSuperior clinical outcomesTransluminal coronary angioplastyMicrovascular reperfusionBalloon timeCoronary angioplastyClinical outcomesMyocardial blushPatient triage
2005
Distal Microcirculatory Protection During Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction: A Randomized Controlled Trial
Stone GW, Webb J, Cox DA, Brodie BR, Qureshi M, Kalynych A, Turco M, Schultheiss HP, Dulas D, Rutherford BD, Antoniucci D, Krucoff MW, Gibbons RJ, Jones D, Lansky AJ, Mehran R, Investigators F. Distal Microcirculatory Protection During Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction: A Randomized Controlled Trial. JAMA 2005, 293: 1063-1072. PMID: 15741528, DOI: 10.1001/jama.293.9.1063.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPercutaneous coronary interventionST-segment resolutionAcute ST-segment elevation myocardial infarctionMajor adverse cardiac eventsAdverse cardiac eventsEvent-free survivalElevation myocardial infarctionDistal protectionInfarct sizeMyocardial infarctionCardiac eventsCoronary interventionReperfusion successBalloon occlusionEmergent percutaneous coronary interventionComplete ST-segment resolutionPrimary percutaneous coronary interventionEnd pointDistal balloon occlusionDistal embolic protectionPrimary PCI resultsCoprimary end pointsSecondary end pointsAcute myocardial infarction
2004
Prognostic utility of comparative methods for assessment of ST-segment resolution after primary angioplasty for acute myocardial infarctionThe controlled abciximab and device investigation to lower late angioplasty complications (CADILLAC) trial
MCLAUGHLIN M, STONE G, AYMONG E, GARDNER G, MEHRAN R, LANSKY A, GRINES C, TCHENG J, COX D, STUCKEY T. Prognostic utility of comparative methods for assessment of ST-segment resolution after primary angioplasty for acute myocardial infarctionThe controlled abciximab and device investigation to lower late angioplasty complications (CADILLAC) trial. Journal Of The American College Of Cardiology 2004, 44: 1215-1223. DOI: 10.1016/s0735-1097(04)01330-0.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary CirculationElectrocardiographyFemaleHeart Conduction SystemHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPostoperative ComplicationsPredictive Value of TestsPrognosisProspective StudiesRecurrenceRisk FactorsStatistics as TopicSurvival AnalysisTreatment OutcomePrognostic utility of comparative methods for assessment of ST-segment resolution after primary angioplasty for acute myocardial infarction The controlled abciximab and device investigation to lower late angioplasty complications (CADILLAC) trial
McLaughlin M, Stone G, Aymong E, Gardner G, Mehran R, Lansky A, Grines C, Tcheng J, Cox D, Stuckey T, Garcia E, Guagliumi G, Turco M, Josephson M, Zimetbaum P. Prognostic utility of comparative methods for assessment of ST-segment resolution after primary angioplasty for acute myocardial infarction The controlled abciximab and device investigation to lower late angioplasty complications (CADILLAC) trial. Journal Of The American College Of Cardiology 2004, 44: 1215-1223. PMID: 15364322, DOI: 10.1016/j.jacc.2004.06.053.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary CirculationElectrocardiographyFemaleHeart Conduction SystemHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPostoperative ComplicationsPredictive Value of TestsPrognosisProspective StudiesRecurrenceRisk FactorsStatistics as TopicSurvival AnalysisTreatment OutcomeConceptsST-segment elevation resolutionPrimary percutaneous coronary interventionPrimary PCIST-segment elevationAcute myocardial infarctionLate Angioplasty Complications (CADILLAC) trialMaximum ST-segment elevationCombined end pointComplications TrialMyocardial infarctionBaseline ST-segment elevationEnd pointInfarct-related artery patencyHigh-risk categorizationPost-PCI electrocardiogramsST-segment resolutionPercutaneous coronary interventionTarget vessel patencyStrong independent predictorControlled AbciximabPrimary angioplastyArtery patencyCoronary interventionIndependent predictorsPrognostic utility869-1 Relationship between time to reperfusion, ST-segment resolution, myocardial blush scores and mortality with primary percutaneous coronary intervention for acute myocardial infarction: Results from the CADILLAC trial
Brodie B, Costantini C, Aymong E, Stuckey T, Cox D, Zimetbaum P, McLaughlin M, Garcia E, Turco M, Mehran R, Grines C, Lansky A, Stone G. 869-1 Relationship between time to reperfusion, ST-segment resolution, myocardial blush scores and mortality with primary percutaneous coronary intervention for acute myocardial infarction: Results from the CADILLAC trial. Journal Of The American College Of Cardiology 2004, 43: a303. DOI: 10.1016/s0735-1097(04)91283-1.Peer-Reviewed Original Research