A gender-specific blood-based gene expression score for assessing obstructive coronary artery disease in nondiabetic patients: Results of the Personalized Risk Evaluation and Diagnosis in the Coronary Tree (PREDICT) Trial
Lansky A, Elashoff MR, Ng V, McPherson J, Lazar D, Kraus WE, Voros S, Schwartz RS, Topol EJ. A gender-specific blood-based gene expression score for assessing obstructive coronary artery disease in nondiabetic patients: Results of the Personalized Risk Evaluation and Diagnosis in the Coronary Tree (PREDICT) Trial. American Heart Journal 2012, 164: 320-326. PMID: 22980297, DOI: 10.1016/j.ahj.2012.05.012.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary artery diseaseMyocardial perfusion imagingGene expression scoreQuantitative coronary angiographyExpression scoreNondiabetic patientsArtery diseaseCardiac catheterizationCoronary angiographyBurden of CADSeverity of CADNoninvasive myocardial perfusion imagingProspective multicenter observational studyUnknown coronary artery diseaseSignificant coronary artery diseaseDiagnostic approachUnnecessary cardiac catheterizationMulticenter observational studyChest pain symptomsDiagnostic cardiac catheterizationAvailable noninvasive testsNoninvasive test resultsPositive predictive valueReliable diagnostic approachWhole Blood Gene Expression Testing for Coronary Artery Disease in Nondiabetic Patients: Major Adverse Cardiovascular Events and Interventions in the PREDICT Trial
Rosenberg S, Elashoff MR, Lieu HD, Brown BO, Kraus WE, Schwartz RS, Voros S, Ellis SG, Waksman R, McPherson JA, Lansky AJ, Topol EJ, for the PREDICT Investigators. Whole Blood Gene Expression Testing for Coronary Artery Disease in Nondiabetic Patients: Major Adverse Cardiovascular Events and Interventions in the PREDICT Trial. Journal Of Cardiovascular Translational Research 2012, 5: 366-374. PMID: 22396313, PMCID: PMC3349850, DOI: 10.1007/s12265-012-9353-z.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary Artery BypassCoronary Artery DiseaseFemaleGene Expression RegulationGenetic Predisposition to DiseaseGenetic TestingHumansIschemic Attack, TransientLogistic ModelsMaleMiddle AgedMyocardial InfarctionOdds RatioPhenotypePredictive Value of TestsPrognosisProspective StudiesReproducibility of ResultsRisk AssessmentRisk FactorsStrokeTime FactorsUnited StatesConceptsMajor adverse cardiovascular eventsCoronary artery diseaseObstructive coronary artery diseaseGene expression scoreAdverse cardiovascular eventsCardiovascular eventsArtery diseaseClinical risk scoreGroup of patientsNegative predictive valueGene expression testingNondiabetic patientsPREDICT trialAngiography patientsGES groupPREDICT studyRisk scorePatientsPredictive valueExpression scoreRevascularizationEvent ratesDiseaseMonthsExpression testingA PERIPHERAL BLOOD GENE EXPRESSION SCORE FOR CORONARY ARTERY DISEASE IN NON-DIABETIC PATIENTS IDENTIFIES PATIENTS AT LOW RISK FOR MAJOR CARDIOVASCULAR EVENTS AND INTERVENTIONAL PROCEDURES IN THE NEXT 12 MONTHS
Kraus W, Voros S, Schwartz R, Ellis S, Waksman R, Tahirkheli N, Lieu H, Elashoff M, Rosenberg S, McPherson J, Lansky A, Topol E. A PERIPHERAL BLOOD GENE EXPRESSION SCORE FOR CORONARY ARTERY DISEASE IN NON-DIABETIC PATIENTS IDENTIFIES PATIENTS AT LOW RISK FOR MAJOR CARDIOVASCULAR EVENTS AND INTERVENTIONAL PROCEDURES IN THE NEXT 12 MONTHS. Journal Of The American College Of Cardiology 2012, 59: e1383. DOI: 10.1016/s0735-1097(12)61384-9.Peer-Reviewed Original ResearchA PREVIOUSLY VALIDATED PERIPHERAL GENE EXPRESSION SCORE IS MOSTLY DETERMINED BY NON-CALCIFIED PLAQUE AND LUMINAL STENOSIS AS ASSESSED BY QUANTITATIVE, 3-DIMENSIONAL MEASUREMENTS BY CT ANGIOGRAPHY IN THE MULTI-CENTER, PROSPECTIVE COMPASS STUDY
Voros S, Thomas G, Lansky A, McPherson J, Elashoff M, Rinehart S, Johnson A, Rosenberg S. A PREVIOUSLY VALIDATED PERIPHERAL GENE EXPRESSION SCORE IS MOSTLY DETERMINED BY NON-CALCIFIED PLAQUE AND LUMINAL STENOSIS AS ASSESSED BY QUANTITATIVE, 3-DIMENSIONAL MEASUREMENTS BY CT ANGIOGRAPHY IN THE MULTI-CENTER, PROSPECTIVE COMPASS STUDY. Journal Of The American College Of Cardiology 2012, 59: e1370. DOI: 10.1016/s0735-1097(12)61371-0.Peer-Reviewed Original Research