2018
Targeted therapy with a localised abluminal groove, low-dose sirolimus-eluting, biodegradable polymer coronary stent (TARGET All Comers): a multicentre, open-label, randomised non-inferiority trial
Lansky A, Wijns W, Xu B, Kelbæk H, van Royen N, Zheng M, Morel MA, Knaapen P, Slagboom T, Johnson TW, Vlachojannis G, Arkenbout KE, Holmvang L, Janssens L, Ochala A, Brugaletta S, Naber CK, Anderson R, Rittger H, Berti S, Barbato E, Toth GG, Maillard L, Valina C, Buszman P, Thiele H, Schächinger V, Baumbach A, Investigators T. Targeted therapy with a localised abluminal groove, low-dose sirolimus-eluting, biodegradable polymer coronary stent (TARGET All Comers): a multicentre, open-label, randomised non-inferiority trial. The Lancet 2018, 392: 1117-1126. PMID: 30190206, DOI: 10.1016/s0140-6736(18)31649-0.Peer-Reviewed Original ResearchConceptsLate lumen lossStent late lumen lossTarget lesion failureCoronary artery diseaseNon-inferiority trialXience groupPrimary endpointLesion failureLumen lossAbluminal grooveAngiographic substudyComers populationArtery diseaseMyocardial ischaemiaMyocardial infarctionIschaemia-driven target lesion revascularisationAsymptomatic coronary artery diseaseTarget vessel myocardial infarctionIschemic coronary artery diseaseST-elevation myocardial infarctionRandom block allocationTarget lesion revascularisationStent thrombosis ratesVessel myocardial infarctionElevation myocardial infarction
2012
A New Score for Risk Stratification of Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention The ACUITY-PCI (Acute Catheterization and Urgent Intervention Triage Strategy–Percutaneous Coronary Intervention) Risk Score
Palmerini T, Genereux P, Caixeta A, Cristea E, Lansky A, Mehran R, Della Riva D, Fahy M, Xu K, Stone GW. A New Score for Risk Stratification of Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention The ACUITY-PCI (Acute Catheterization and Urgent Intervention Triage Strategy–Percutaneous Coronary Intervention) Risk Score. JACC Cardiovascular Interventions 2012, 5: 1108-1116. PMID: 23174634, DOI: 10.1016/j.jcin.2012.07.011.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute coronary syndromeCoronary artery diseaseRisk scoreRisk stratificationCoronary syndromeCoronary interventionArtery diseaseElectrocardiographic variablesSegment elevation acute coronary syndromesElevation acute coronary syndromeDiffuse coronary artery diseaseCardiac biomarker elevationClinical SYNTAX scoreEarly invasive strategyGRACE risk scoreTIMI risk scoreInsulin-treated diabetesNet reclassification improvementNew scoreBetter prognostic accuracyST-segment deviationACUITY trialAngiographic substudyRenal insufficiency
2011
Prognostic Value of the SYNTAX Score in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage StrategY) Trial
Palmerini T, Genereux P, Caixeta A, Cristea E, Lansky A, Mehran R, Dangas G, Lazar D, Sanchez R, Fahy M, Xu K, Stone GW. Prognostic Value of the SYNTAX Score in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage StrategY) Trial. Journal Of The American College Of Cardiology 2011, 57: 2389-2397. PMID: 21658558, DOI: 10.1016/j.jacc.2011.02.032.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngioplasty, Balloon, CoronaryCardiac CatheterizationCoronary AngiographyCoronary Artery BypassElectrocardiographyEmergency TreatmentFemaleHeparin, Low-Molecular-WeightHirudinsHospital MortalityHumansItalyKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisPeptide FragmentsPrognosisProportional Hazards ModelsProspective StudiesRecombinant ProteinsRisk AssessmentROC CurveSeverity of Illness IndexStatistics, NonparametricSurvival AnalysisTreatment OutcomeTriageConceptsSegment elevation acute coronary syndromesElevation acute coronary syndromePercutaneous coronary interventionAcute coronary syndromeSYNTAX scoreCoronary syndromeCardiac deathACUITY trialIndependent predictorsPredictive valueTarget vessel revascularization rateStable ischemic heart diseaseTriple-vessel coronary diseaseVessel revascularization rateCardiac mortality rateMyocardial infarction ratePre-specified subgroupsRisk-stratify patientsIschemic heart diseaseAngiographic substudySS tertilesInfarction rateRevascularization ratesCoronary interventionCoronary disease
2004
Randomized trial of Rotational Atherectomy Versus Balloon Angioplasty for Diffuse In-stent Restenosis (ROSTER)
Sharma SK, Kini A, Mehran R, Lansky A, Kobayashi Y, Marmur JD. Randomized trial of Rotational Atherectomy Versus Balloon Angioplasty for Diffuse In-stent Restenosis (ROSTER). American Heart Journal 2004, 147: 16-22. PMID: 14691413, DOI: 10.1016/j.ahj.2003.07.002.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationPrimary end pointDiffuse ISRPTCA groupBalloon angioplastyBalloon dilatationStent restenosisCoronary artery bypass graft proceduresIn-Stent Restenosis TrialStudy's primary end pointEnd pointHigh-pressure balloon dilatationRotational coronary atherectomySecondary end pointsBypass graft proceduresIntravascular ultrasound studyAcute luminal gainAdjunctive balloon dilatationIntimal hyperplasia areaAngiographic substudyAngiographic variablesLesion revascularizationRepeat stentingAngiographic restenosisAngiographic success
2003
Benefits and Risks of Abciximab Use in Primary Angioplasty for Acute Myocardial Infarction
Tcheng JE, Kandzari DE, Grines CL, Cox DA, Effron MB, Garcia E, Griffin JJ, Guagliumi G, Stuckey T, Turco M, Fahy M, Lansky AJ, Mehran R, Stone GW. Benefits and Risks of Abciximab Use in Primary Angioplasty for Acute Myocardial Infarction. Circulation 2003, 108: 1316-1323. PMID: 12939213, DOI: 10.1161/01.cir.0000087601.45803.86.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAdultAgedAngioplasty, Balloon, CoronaryAntibodies, MonoclonalCombined Modality TherapyCoronary AngiographyEndpoint DeterminationFemaleHumansImmunoglobulin Fab FragmentsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexStentsTreatment OutcomeConceptsComposite end pointTarget vessel revascularizationIschemia-driven target vessel revascularizationPrimary percutaneous coronary interventionAbciximab treatmentPercutaneous coronary interventionAcute myocardial infarctionMyocardial infarctionCoronary interventionEnd pointPlatelet glycoprotein IIb/IIIa inhibitorsGlycoprotein IIb/IIIa inhibitorsIIb/IIIa inhibitorsInfarct artery reocclusionPrespecified secondary analysisEvent-free survivalFactorial design trialLack of effectAbciximab useAngiographic substudyCADILLAC trialTVR ratesPrimary angioplastyPrimary stentingAngiographic outcomes