Semaphorin3a inhibits ureteric bud branching morphogenesis
Tufro A, Teichman J, Woda C, Villegas G. Semaphorin3a inhibits ureteric bud branching morphogenesis. Cells And Development 2007, 125: 558-568. PMID: 18249526, PMCID: PMC3992265, DOI: 10.1016/j.mod.2007.12.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBinding, CompetitiveBody PatterningGlial Cell Line-Derived Neurotrophic FactorMiceModels, BiologicalOligonucleotides, AntisenseProto-Oncogene Proteins c-aktRecombinant ProteinsSemaphorin-3ASignal TransductionUreterVascular Endothelial Growth Factor AConceptsUreteric budUreteric bud branchingAkt survival pathwayUreteric bud treeUreteric bud cellsAntisense morpholinoClass 3 semaphorinsVascular patterningMetanephric organ cultureFactor signalingMouse embryosNegative regulatorKidney developmentSurvival pathwaysGuidance proteinsNeurotrophic Factor SignalingSema3A effectBudsRenal epitheliumMorphogenesisBud cellsMutant miceRecombinant Sema3AGrowth factorSema3ACrosstalk between VEGF-A/VEGFR2 and GDNF/RET signaling pathways
Tufro A, Teichman J, Banu N, Villegas G. Crosstalk between VEGF-A/VEGFR2 and GDNF/RET signaling pathways. Biochemical And Biophysical Research Communications 2007, 358: 410-416. PMID: 17490619, DOI: 10.1016/j.bbrc.2007.04.146.Peer-Reviewed Original ResearchMeSH KeywordsCell EnlargementCell LineCell ProliferationGlial Cell Line-Derived Neurotrophic FactorHumansMorphogenesisProto-Oncogene Proteins c-retSignal TransductionUreterVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2ConceptsVascular endothelial growth factorCell proliferationEndothelial growth factorNeurotrophic factorGDNF/RETEmbryonic kidney explantsUreteric bud branchingUreteric bud cellsC-RetGrowth factorRT-PCRVEGFNovel cooperative interactionVEGFR2Branching morphogenesisRETVEGFR2 autophosphorylationGDNFKidney developmentBud cellsUreteric budAdditive effectMajor regulatorKidney explantsPhosphorylation