2014
Biodistribution and Radiation Dosimetry of LMI1195: First-in-Human Study of a Novel 18F-Labeled Tracer for Imaging Myocardial Innervation
Sinusas AJ, Lazewatsky J, Brunetti J, Heller G, Srivastava A, Liu YH, Sparks R, Puretskiy A, Lin SF, Crane P, Carson RE, Lee LV. Biodistribution and Radiation Dosimetry of LMI1195: First-in-Human Study of a Novel 18F-Labeled Tracer for Imaging Myocardial Innervation. Journal Of Nuclear Medicine 2014, 55: 1445-1451. PMID: 24994931, DOI: 10.2967/jnumed.114.140137.Peer-Reviewed Original ResearchConceptsAdministered activityBlood-pool standardized uptake valuesPhase 1 clinical trialCardiac nerve terminalsCardiac imagingMSv/MBqMean effective doseStandardized uptake valueRadiation doseOLINDA/EXMPatient radiation doseRadiation dose estimatesAdverse eventsBlood pressureWhole-body imagesClinical trialsBlood radioactivityMyocardial innervationNerve terminalsUrinary bladderHealthy subjectsLiver ratioHeart rateLung activityMyocardial uptake
2001
Technetium-99m-labeled Myocardial Perfusion Agents: Are They Better than Thallium-201?
Kailasnath P, Sinusas A. Technetium-99m-labeled Myocardial Perfusion Agents: Are They Better than Thallium-201? Cardiology In Review 2001, 9: 160-172. PMID: 11304401, DOI: 10.1097/00045415-200105000-00009.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePerfusion tracerPerfusion agentArtery diseaseMyocardial viabilityThallium-201Perfusion imagingMyocardial perfusion imagingRegional flow heterogeneityPharmacologic stressorChest painMyocardial perfusion agentRisk stratificationAcute assessmentNew perfusion agentTechnetium-99mClinical valueMyocardial uptakeIschemic regionAssessment of viabilityCoronary vasculatureMyocardial flowClearance kineticsMyocardial retentionTracer availability
1993
Myocardial risk area defined by technetium-99m sestamibi imaging during percutaneous transluminal coronary angioplasty: Comparison with coronary angiography
Haronian H, Remetz M, Sinusas A, Baron J, Miller H, Cleman M, Zaret B, Wackers F. Myocardial risk area defined by technetium-99m sestamibi imaging during percutaneous transluminal coronary angioplasty: Comparison with coronary angiography. Journal Of The American College Of Cardiology 1993, 22: 1033-1043. PMID: 8409038, DOI: 10.1016/0735-1097(93)90413-u.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryClinical ProtocolsCollateral CirculationCoronary AngiographyCoronary DiseaseEvaluation Studies as TopicFemaleHumansMaleMiddle AgedMyocardial InfarctionObserver VariationPredictive Value of TestsPrognosisReproducibility of ResultsRisk FactorsSeverity of Illness IndexTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonConceptsMyocardial risk areaCoronary angiographyCoronary angioplastyQuantitative myocardial perfusionMyocardial perfusionMyocardial areaPercutaneous transluminal coronary angioplastyAngiographic risk scoresSmall risk areasTransluminal coronary angioplastyCoronary artery diseaseCoronary artery stenosisInitial myocardial uptakeAngioplasty balloon inflationArtery diseaseLeft anteriorNonperfused areaArtery stenosisCoronary anatomyCoronary arteryBalloon inflationPatient managementMyocardial uptakeRisk scoreAngioplasty
1989
Effect of ischemia and postischemic dysfunction on myocardial uptake of technetium-99m-labeled methoxyisobutyl isonitrile and thallium-201
Sinusas A, Watson D, Cannon J, Beller G. Effect of ischemia and postischemic dysfunction on myocardial uptake of technetium-99m-labeled methoxyisobutyl isonitrile and thallium-201. Journal Of The American College Of Cardiology 1989, 14: 1785-1793. PMID: 2584570, DOI: 10.1016/0735-1097(89)90034-x.Peer-Reviewed Original ResearchConceptsLow coronary flowThallium-201Postischemic dysfunctionMyocardial uptakeArtery occlusionMethoxyisobutyl isonitrileEndocardial flowCoronary flowGroup II dogsTwo-dimensional echocardiographyEffects of ischemiaRegional blood flowOpen-chest canine modelMyocardial perfusion agentEpicardial segmentsRadionuclide injectionBlood flowEndocardial segmentsRegional dysfunctionIschemic regionLeft ventricleCanine modelDysfunctionGroup IPerfusion agent