2023
Variation in hospital use of cardiac resynchronization therapy-defibrillator among eligible patients and association with clinical outcomes
Chui P, Lan Z, Freeman J, Enriquez A, Khera R, Akar J, Masoudi F, Ong E, Curtis J. Variation in hospital use of cardiac resynchronization therapy-defibrillator among eligible patients and association with clinical outcomes. Heart Rhythm 2023, 20: 1000-1008. PMID: 36963741, DOI: 10.1016/j.hrthm.2023.03.022.Peer-Reviewed Original ResearchConceptsEligible patientsICD RegistryCardiac resynchronizationNational Cardiovascular Data Registry ICD RegistryCRT-D implantationCRT-D useHospital-level outcomesStrong guideline recommendationsHospital-level variationPatient-level outcomesIntraclass correlation coefficientQuality improvement effortsHospital mortalityGuideline indicationsReadmission ratesSelect patientsClinical outcomesGuideline recommendationsHospital variationHospital ratesUse of CRTHospital levelHospital usePatientsCase mix
2020
Mortality and readmission in non-ischemic compared with ischemic cardiomyopathies after implantable cardioverter-defibrillator implantation
Freeman J, Bjerre J, Parzynski C, Minges K, Ahmad T, Desai N, Enriquez A, Spatz E, Friedman D, Curtis J, Hlatky M, Higgins A. Mortality and readmission in non-ischemic compared with ischemic cardiomyopathies after implantable cardioverter-defibrillator implantation. European Heart Journal 2020, 41: ehaa946.0788. DOI: 10.1093/ehjci/ehaa946.0788.Peer-Reviewed Original ResearchNon-ischemic cardiomyopathyImplantable cardioverter defibrillator implantationPrimary prevention ICDsCardioverter-defibrillator implantationIschemic cardiomyopathyICM patientsNational Cardiovascular Data Registry ICD RegistryCox proportional hazards regression modelPrimary prevention ICD implantationLeft ventricular ejection fractionProportional hazards regression modelsOne-year mortalityHeart failure readmissionVentricular ejection fractionKaplan-Meier curvesHazards regression modelsRisk of mortalityMedian followCause readmissionICD implantationEjection fractionHeart failureHospital readmissionICD RegistryPatient subgroupsArrhythmias During Pregnancy and Postpartum
Enriquez A, Tedrow U. Arrhythmias During Pregnancy and Postpartum. Contemporary Cardiology 2020, 645-669. DOI: 10.1007/978-3-030-41967-7_28.ChaptersStructural heart diseaseLong safety recordType of arrhythmiaFetal outcomesRefractory arrhythmiasDevice therapyAntiarrhythmic drugsCatheter ablationAtrial fibrillationFirst trimesterCommon arrhythmiaPatient populationHeart diseaseSevere symptomsCardiac arrhythmiasArrhythmiasTherapeutic interventionsPregnancyMaternal populationMinimal dataTherapySafety recordTrimesterFibrillationPostpartum
2019
BUNDLE BRANCH REENTRANT VENTRICULAR TACHYCARDIA AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT
Workman V, Freeman J, Forrest J, Upadhyaya K, Carney K, Enriquez A. BUNDLE BRANCH REENTRANT VENTRICULAR TACHYCARDIA AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT. Journal Of The American College Of Cardiology 2019, 73: 2934. DOI: 10.1016/s0735-1097(19)33540-5.Peer-Reviewed Case Reports and Technical Notes
2015
Impact of general anesthesia on initiation and stability of VT during catheter ablation
Nof E, Reichlin T, Enriquez AD, Ng J, Nagashima K, Tokuda M, Barbhaiya C, John RM, Michaud GF, Tedrow U, Gross W, Stevenson WG. Impact of general anesthesia on initiation and stability of VT during catheter ablation. Heart Rhythm 2015, 12: 2213-2220. PMID: 26072026, DOI: 10.1016/j.hrthm.2015.06.018.Peer-Reviewed Original ResearchMeSH KeywordsAnesthesia, GeneralBody Surface Potential MappingBostonCatheter AblationCohort StudiesConscious SedationFemaleFollow-Up StudiesHospitals, UniversityHumansIsraelMalePostoperative ComplicationsRecurrenceRetrospective StudiesRisk AssessmentSeverity of Illness IndexStatistics, NonparametricSwitzerlandTachycardia, VentricularTreatment OutcomeConceptsClinical ventricular tachycardiaGeneral anesthesiaInducible ventricular tachycardiaInduced ventricular tachycardiaVentricular tachycardiaHemodynamic supportVT inducibilityConscious sedationRadiofrequency ablationEffects of GANonclinical ventricular tachycardiaLow ejection fractionMajority of patientsIntravenous conscious sedationEjection fractionNonischemic cardiomyopathyCatheter ablationRetrospective studyVT inductionVT morphologiesProspective groupRetrospective comparisonGA groupPatientsProcedure outcomesBetter outcome of ablation for sustained outflow-tract ventricular tachycardia when tachycardia is inducible
Choi EK, Kumar S, Nagashima K, Lin KY, Barbhaiya CR, Chinitz JS, Enriquez AD, Helmbold AF, Baldinger SH, Tedrow UB, Koplan BA, Michaud GF, John RM, Epstein LM, Stevenson WG. Better outcome of ablation for sustained outflow-tract ventricular tachycardia when tachycardia is inducible. EP Europace 2015, 17: 1571-1579. PMID: 25840288, DOI: 10.1093/europace/euv064.Peer-Reviewed Original ResearchConceptsPremature ventricular contractionsOvert structural heart diseaseOutflow tract ventricular tachycardiaMultiple VT morphologiesInducible ventricular tachycardiaStructural heart diseaseSustained ventricular tachycardiaVentricular tachycardiaInducible groupHeart diseaseVT morphologiesBetter outcomesInducibility of VTSpontaneous sustained ventricular tachycardiaCatheter ablationOutflow tract regionAblation outcomesMM groupVentricular contractionsGreat vesselsPatientsSM groupTachycardiaPVC morphologyOutcomes“Needle-in-needle” epicardial access: Preliminary observations with a modified technique for facilitating epicardial interventional procedures
Kumar S, Bazaz R, Barbhaiya CR, Enriquez AD, Helmbold AF, Chinitz JS, Baldinger SH, Mahida S, McConville JW, Tedrow UB, John RM, Michaud GF, Stevenson WG. “Needle-in-needle” epicardial access: Preliminary observations with a modified technique for facilitating epicardial interventional procedures. Heart Rhythm 2015, 12: 1691-1697. PMID: 25828599, DOI: 10.1016/j.hrthm.2015.03.045.Peer-Reviewed Original Research
2014
Incidence, predictors, and evolution of conduction disorders and atrial arrhythmias after contemporary mitral valve repair
Viles-Gonzalez JF, Enriquez AD, Castillo JG, Coffey JO, Pastori L, Reddy VY, Adams DH, Fuster V. Incidence, predictors, and evolution of conduction disorders and atrial arrhythmias after contemporary mitral valve repair. Cardiology Journal 2014, 21: 569-575. PMID: 24526511, DOI: 10.5603/cj.a2014.0016.Peer-Reviewed Original ResearchMeSH KeywordsArrhythmias, CardiacAtrial FibrillationAtrioventricular BlockBrugada SyndromeBundle-Branch BlockCardiac Conduction System DiseaseCardiac Surgical ProceduresElectrocardiographyFemaleHeart Conduction SystemHeart Valve DiseasesHumansIncidenceMaleMiddle AgedMitral ValvePostoperative ComplicationsRetrospective StudiesRisk FactorsUnited StatesConceptsRight bundle branch blockMitral valve repairAtrio-ventricular blockAtrial arrhythmiasConduction disordersBypass timeAtrial sizeCardiac surgeryIndependent predictorsValve repairMultivariate predictorsFirst degree atrio-ventricular blockConcomitant mitral valve repairDegree atrio-ventricular blockOnly multivariate predictorPrior cardiac surgeryPrompt clinical recoverySignificant valvular regurgitationComplete atrio-ventricular blockTreatment of choiceLength of stayBundle branch blockCommon atrial arrhythmiaPreoperative pacemakerProlong hospitalizationClinical Impact of Atrial Fibrillation in Patients With the HeartMate II Left Ventricular Assist Device
Enriquez AD, Calenda B, Gandhi PU, Nair AP, Anyanwu AC, Pinney SP. Clinical Impact of Atrial Fibrillation in Patients With the HeartMate II Left Ventricular Assist Device. Journal Of The American College Of Cardiology 2014, 64: 1883-1890. PMID: 25444141, DOI: 10.1016/j.jacc.2014.07.989.Peer-Reviewed Original ResearchConceptsParoxysmal atrial fibrillationAtrial fibrillationHF hospitalizationThromboembolic eventsVentricular assist deviceHeartMate IIHMII LVADAssist deviceImpact of AFCox proportional hazards regressionEffect of AFKaplan-Meier survival analysisHigh INR levelsHeart failure hospitalizationMajor bleeding eventsPersistent atrial fibrillationProportional hazards regressionBleeding eventsHMII implantationINR levelsFailure hospitalizationPatient yearsComposite endpointIndependent predictorsClinical outcomesContemporary Management of Arrhythmias During Pregnancy
Enriquez AD, Economy KE, Tedrow UB. Contemporary Management of Arrhythmias During Pregnancy. Circulation Arrhythmia And Electrophysiology 2014, 7: 961-967. PMID: 25336366, DOI: 10.1161/circep.114.001517.Peer-Reviewed Original ResearchAvoiding tachycardia alteration or termination during attempted entrainment mapping of atrial tachycardia related to atrial fibrillation ablation
Barbhaiya CR, Kumar S, Ng J, Nagashima K, Choi EK, Enriquez A, Chinitz J, Epstein LM, Tedrow UB, John RM, Stevenson WG, Michaud GF. Avoiding tachycardia alteration or termination during attempted entrainment mapping of atrial tachycardia related to atrial fibrillation ablation. Heart Rhythm 2014, 12: 32-35. PMID: 25194901, DOI: 10.1016/j.hrthm.2014.09.002.Peer-Reviewed Original ResearchCorrelates and Prognosis of Early Recurrence After Catheter Ablation for Ventricular Tachycardia due to Structural Heart Disease
Nagashima K, Choi EK, Tedrow UB, Koplan BA, Michaud GF, John RM, Epstein LM, Tokuda M, Inada K, Kumar S, Lin KY, Barbhaiya CR, Chinitz JS, Enriquez AD, Helmbold AF, Stevenson WG. Correlates and Prognosis of Early Recurrence After Catheter Ablation for Ventricular Tachycardia due to Structural Heart Disease. Circulation Arrhythmia And Electrophysiology 2014, 7: 883-888. PMID: 25136076, DOI: 10.1161/circep.114.001461.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnti-Arrhythmia AgentsCatheter AblationChi-Square DistributionFemaleHeart DiseasesHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioProportional Hazards ModelsRecurrenceRetrospective StudiesRisk FactorsTachycardia, VentricularTime FactorsTreatment OutcomeConceptsStructural heart diseaseEarly VT recurrenceVentricular tachycardiaEarly recurrenceHeart diseaseVT recurrenceCatheter ablationNew York Heart Association classificationSustained monomorphic ventricular tachycardiaFirst radiofrequency ablationOptimal treatment strategyHigh-risk groupInduced ventricular tachycardiaMonomorphic ventricular tachycardiaVT stormClinical profileMultivariable analysisPrognostic significancePatient groupIndependent correlatesAssociation classificationRadiofrequency ablationRisk groupsTreatment strategiesAcute failureManagement of Hypertrophic Cardiomyopathy
Enriquez AD, Goldman ME. Management of Hypertrophic Cardiomyopathy. Annals Of Global Health 2014, 80: 35-45. PMID: 24751563, DOI: 10.1016/j.aogh.2013.12.004.Peer-Reviewed Original ResearchConceptsSudden cardiac deathHypertrophic cardiomyopathyHeart failureAtrial fibrillationHCM patientsManagement of HCMCommon genetic cardiovascular diseaseUnexplained myocardial hypertrophyAlcohol septal ablationOutflow tract obstructionRhythm control strategyPathophysiology of HCMRisk of thromboembolismMajority of patientsGeneral adult populationGenetic cardiovascular diseaseAutosomal dominant diseaseFamily membersSurgical myectomyRefractory symptomsRestrictive physiologySeptal ablationTract obstructionYounger patientsCardiac deathTHE CLINICAL IMPACT OF ATRIAL FIBRILLATION IN PATIENTS WITH THE HEARTMATE II LEFT VENTRICULAR ASSIST DEVICE
Enriquez A, Calenda B, Gandhi P, Nair A, Anyanwu A, Pinney S. THE CLINICAL IMPACT OF ATRIAL FIBRILLATION IN PATIENTS WITH THE HEARTMATE II LEFT VENTRICULAR ASSIST DEVICE. Journal Of The American College Of Cardiology 2014, 63: a888. DOI: 10.1016/s0735-1097(14)60888-3.Peer-Reviewed Original Research
2013
The Role of Implantable Cardioverter-Defibrillators in Patients With Continuous Flow Left Ventricular Assist Devices
Enriquez AD, Calenda B, Miller MA, Anyanwu AC, Pinney SP. The Role of Implantable Cardioverter-Defibrillators in Patients With Continuous Flow Left Ventricular Assist Devices. Circulation Arrhythmia And Electrophysiology 2013, 6: 668-674. PMID: 23873139, DOI: 10.1161/circep.113.000457.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedArrhythmias, CardiacChi-Square DistributionDefibrillators, ImplantableElectric CountershockFemaleHeart FailureHeart TransplantationHeart-Assist DevicesHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMultivariate AnalysisNew York CityProportional Hazards ModelsProsthesis DesignRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeVentricular Function, LeftWaiting ListsYoung AdultConceptsVentricular arrhythmiasActive ICDPost-LVAD ventricular arrhythmiasVentricular assist device supportAssist device supportContinuous-flow LVADHeartMate II LVADEnd of studyImplantable cardioverter defibrillatorVentricular assist deviceAppropriate shocksConsecutive patientsImproved survivalIschemic cardiomyopathySingle centerWorse prognosisMedian lengthMean agePatient populationCardioverter defibrillatorPatientsDevice supportAssist deviceICDLVAD
2008
Human oligodendrocytes express Cx31.3: function and interactions with Cx32 mutants.
Sargiannidou I, Ahn M, Enriquez AD, Peinado A, Reynolds R, Abrams C, Scherer SS, Kleopa KA. Human oligodendrocytes express Cx31.3: function and interactions with Cx32 mutants. Neurobiology Of Disease 2008, 30: 221-33. PMID: 18353664, PMCID: PMC2704064, DOI: 10.1016/j.nbd.2008.01.009.Peer-Reviewed Original ResearchCx29 and Cx32, two connexins expressed by myelinating glia, do not interact and are functionally distinct.
Ahn M, Lee J, Gustafsson A, Enriquez A, Lancaster E, Sul JY, Haydon PG, Paul DL, Huang Y, Abrams CK, Scherer SS. Cx29 and Cx32, two connexins expressed by myelinating glia, do not interact and are functionally distinct. Journal Of Neuroscience Research 2008, 86: 992-1006. PMID: 17972320, PMCID: PMC2663799, DOI: 10.1002/jnr.21561.Peer-Reviewed Original Research
2007
Cost-effectiveness of suppressing hepatitis B virus DNA in immune tolerant patients to prevent hepatocellular carcinoma and cirrhosis.
Enriquez AD, Campbell MS, Reddy KR. Cost-effectiveness of suppressing hepatitis B virus DNA in immune tolerant patients to prevent hepatocellular carcinoma and cirrhosis. Alimentary Pharmacology & Therapeutics 2007, 26: 383-91. PMID: 17635373, DOI: 10.1111/j.1365-2036.2007.03382.x.Peer-Reviewed Original ResearchLoss-of-function GJA12/Connexin47 mutations cause Pelizaeus-Merzbacher-like disease.
Orthmann-Murphy JL, Enriquez AD, Abrams CK, Scherer SS. Loss-of-function GJA12/Connexin47 mutations cause Pelizaeus-Merzbacher-like disease. Molecular And Cellular Neurosciences 2007, 34: 629-41. PMID: 17344063, PMCID: PMC1937038, DOI: 10.1016/j.mcn.2007.01.010.Peer-Reviewed Original Research
2004
Unique distributions of the gap junction proteins connexin29, connexin32, and connexin47 in oligodendrocytes.
Kleopa KA, Orthmann JL, Enriquez A, Paul DL, Scherer SS. Unique distributions of the gap junction proteins connexin29, connexin32, and connexin47 in oligodendrocytes. Glia 2004, 47: 346-57. PMID: 15293232, DOI: 10.1002/glia.20043.Peer-Reviewed Original Research