2008
The Influence of Injury on Toll-Like Receptor Responses
Murphy T, Maung A, Paterson H, Lederer J. The Influence of Injury on Toll-Like Receptor Responses. 2008, 185-202. DOI: 10.1201/9781420043198-17.ChaptersToll-like receptorsToll-like receptor responsesAdaptive immune responsesInfluence of injuryStrong inflammatory responseInnate immune systemCommon microbial antigensSentinel receptorsTLR ligandsMicrobial antigensInflammatory responseViral antigensTissue injuryTLR responsesImmune responseCell injuryReceptor responsesImmune systemTissue damageInjury responseEndogenous factorsMicrobial ligandsInjuryInfectionIntracellular receptors
2006
Platelet depletion in mice increases mortality after thermal injury
Fujimi S, MacConmara MP, Maung AA, Zang Y, Mannick JA, Lederer JA, Lapchak PH. Platelet depletion in mice increases mortality after thermal injury. Blood 2006, 107: 4399-4406. PMID: 16467203, PMCID: PMC1895793, DOI: 10.1182/blood-2005-09-3776.Peer-Reviewed Original ResearchConceptsControl miceFull-thickness total body surface areaHost responseThermal injuryTotal body surface areaExperimental control miceSystemic inflammatory responsePlatelet-depleted miceRole of plateletsBody surface areaCause of deathCritical protective rolePeripheral blood monocytesImportance of plateletsSham injuryIL-6MCP-1Plasma levelsPlatelet depletionInflammatory responseImmune responseAdaptive immunityBlood monocytesMouse modelProtective role