Adithya Sivaraju, MD, MHA
Associate Professor TermCards
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Director, Epilepsy Fellowship
Director, Post Acute Symptomatic Seizure (PASS) Clinic
Director, Cortical Stimulation Mapping Program
Comprehensive Epilepsy Center
Department of Neurology
About
Titles
Associate Professor Term
Director, Epilepsy Fellowship; Director, Post Acute Symptomatic Seizure (PASS) Clinic; Director, Cortical Stimulation Mapping Program; Comprehensive Epilepsy Center; Department of Neurology
Biography
Dr. Sivaraju completed his medical school from Andhra medical college, India. He was resident and chief resident of neurology at the Rutgers University, New Jersey Medical School. He then completed a two-year fellowship in epilepsy and clinical neurophysiology at Yale university, and stayed back on faculty as an assistant professor in the department of neurology. His research interests and publications are on topics including epilepsy surgery, intracranial EEG monitoring, cortical stimulation and management of acute symptomatic seizures.
Appointments
Neurology
Associate Professor on TermPrimary
Other Departments & Organizations
Education & Training
- Fellow
- Yale University (2015)
- Resident
- Rutgers University, NJMS (2013)
- Chief Resident
- Rutgers University, NJMS (2013)
- Intern
- Rutgers University, NJMS (2010)
- MHA
- University of North Carolina at Charlotte (UNCC)., Health Care Administration (2009)
- MD
- Andhra University (2007)
Research
Overview
Medical Research Interests
ORCID
0000-0002-6027-9205
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Lawrence Hirsch, MD
Eyiyemisi Damisah, MD
Emily J. Gilmore, MD, FNCS, FACNS
Imran Quraishi, MD, PhD
Dennis Spencer, MD
Hari Mcgrath
Electroencephalography
Seizures
Epilepsy
Coma
Publications
Featured Publications
Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom
Sivaraju A, Quraishi I, Collins E, McGrath H, Ramos A, Turk-Browne N, Zaveri H, Damisah E, Spencer D, Hirsch L. Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom. Brain Stimulation 2024, 17: 339-345. PMID: 38490472, DOI: 10.1016/j.brs.2024.03.011.Peer-Reviewed Original ResearchConceptsSeizure inductionSeizure onset zoneSurgical outcomesHabitual seizuresOnset zonePredicting seizure freedomExcellent surgical outcomesProspective cohort studyMann-Whitney testConsecutive patientsFisher's exactSeizure freedomRefractory epilepsyCohort studyPost-surgeryInsular regionsMann-WhitneyPatientsIntracranial EEGSeizuresLocalizing seizure onset zonesStimulationElectrical stimulationMedial temporal regionsTemporal regionsFactors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy
Sivaraju A, Hirsch L, Gaspard N, Farooque P, Gerrard J, Xu Y, Deng Y, Damisah E, Blumenfeld H, Spencer DD. Factors Predicting Outcome After Intracranial EEG Evaluation in Patients With Medically Refractory Epilepsy. Neurology 2022, 99: e1-e10. PMID: 35508395, PMCID: PMC9259091, DOI: 10.1212/wnl.0000000000200569.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsTemporal lobe onsetSeizure freedomResective surgeryIndependent predictorsLesional MRIUnfavorable predictorRefractory epilepsyContinued medical treatmentEpilepsy surgical evaluationFactors Predicting OutcomeIntracranial EEG evaluationNonlesional extratemporal epilepsySubsequent seizure freedomSustained seizure freedomThorough presurgical evaluationSeizure-free outcomeClass II evidenceMedically Refractory EpilepsyRetrospective chart reviewKaplan-Meier curvesSelect clinical scenariosMultivariable regression analysisBest multivariable modelIntracranial EEGSeizure onset localizationIntrastimulation discharges during electrical stimulation mapping May help identify seizure onset network
Sivaraju A, Spencer DD, Hirsch LJ. Intrastimulation discharges during electrical stimulation mapping May help identify seizure onset network. Brain Stimulation 2021, 14: 652-654. PMID: 33826933, DOI: 10.1016/j.brs.2021.04.003.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsBeyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventions
Percy J, Zaveri H, Duckrow RB, Gerrard J, Farooque P, Hirsch LJ, Spencer DD, Sivaraju A. Beyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventions. Epilepsy & Behavior 2020, 111: 107231. PMID: 32615416, DOI: 10.1016/j.yebeh.2020.107231.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsLong-term seizure freedomSeizure freedomSeizure frequencyElectrode implantationIntracranial studiesLong-term seizure reductionAdditional surgical interventionSeizure onset localizationIntracranial electroencephalogram monitoringSeizure reductionConsecutive patientsSurgical interventionEpileptogenic networksElectroencephalogram monitoringNeuromodulatory effectsRetrospective analysisIntracranial monitoringTransient improvementDepth electrodesPatientsYear 4ImplantationAdequate dataYearsInvasive EEG in presurgical evaluation of epilepsy
Spencer D, Nguyen D, Sivaraju A. Invasive EEG in presurgical evaluation of epilepsy. 2015, 733-755. DOI: 10.1002/9781118936979.ch58.Peer-Reviewed Original ResearchConceptsEpileptogenic lesionsMRI protocolEarly treatment optionEpilepsy surgical procedureNon-surgical candidatesCommon epileptogenic lesionsSpecific MRI protocolQuality of MRIEpilepsy surgeryMRI criteriaPresurgical evaluationTreatment optionsCerebral areasInvasive EEGSurgical proceduresNeurosurgical proceduresMR imagingMR spectroscopyLesionsEpilepsyTypical featuresImagingPatientsSurgeryPathologyPrognostication of post-cardiac arrest coma: early clinical and electroencephalographic predictors of outcome
Sivaraju A, Gilmore EJ, Wira CR, Stevens A, Rampal N, Moeller JJ, Greer DM, Hirsch LJ, Gaspard N. Prognostication of post-cardiac arrest coma: early clinical and electroencephalographic predictors of outcome. Intensive Care Medicine 2015, 41: 1264-1272. PMID: 25940963, DOI: 10.1007/s00134-015-3834-x.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsBetter outcomesPoor outcomeEpileptiform dischargesPost-cardiac arrest comatose patientsCritical care EEG terminologyPost-cardiac arrest comaMethodsProspective cohort studyContinuous EEG monitoringLow-voltage EEGPositive predictive valueAbsence of reactivityEEG terminologyCohort studySpontaneous circulationBrainstem reflexesClinical outcomesComatose patientsFalse positive ratePoor prognosisPrognostic significanceSuppression burstsClinical variablesClinical correlatesElectroencephalographic patternsElectroencephalographic predictorsImmediate and long‐term management practices of acute symptomatic seizures and epileptiform abnormalities: A cross‐sectional international survey
Punia V, Daruvala S, Dhakar M, Zafar S, Rubinos C, Ayub N, Hirsch L, Sivaraju A, investigators F. Immediate and long‐term management practices of acute symptomatic seizures and epileptiform abnormalities: A cross‐sectional international survey. Epilepsia 2024, 65: 909-919. PMID: 38358383, DOI: 10.1111/epi.17915.Peer-Reviewed Original ResearchConceptsAnti-seizure medicationsEpileptiform abnormalitiesAcute symptomatic seizuresAcute brain injuryContinuous EEGSecondary prophylaxisSymptomatic seizuresSporadic epileptiform dischargesLateralized periodic dischargesCross-sectional international surveyOutpatient follow-upAnti-seizure medication useOptimal care pathwayDose escalationBrain injuryDose changesLong-term managementElectrographic seizuresEpileptiform dischargesFollow-upAncillary testsReal-world practiceRecommended durationContinuous electroencephalographyHospital discharge
2024
Antiseizure Medication Use and Outcomes After Suspected or Confirmed Acute Symptomatic Seizures
Zafar S, Sivaraju A, Rubinos C, Ayub N, Awodutire P, McKee Z, Chandan P, Byrnes M, Bhansali S, Rice H, Smith-Ayala A, Haider M, Tveter E, Erlich-Malona N, Ibanhes F, DeMarco A, Lewis S, Dhakar M, Punia V. Antiseizure Medication Use and Outcomes After Suspected or Confirmed Acute Symptomatic Seizures. JAMA Neurology 2024, 81: 1159-1169. PMID: 39312247, PMCID: PMC11420826, DOI: 10.1001/jamaneurol.2024.3189.Peer-Reviewed Original ResearchConceptsAssociated with increased oddsAcute symptomatic seizuresAntiseizure medication treatmentDischarge prescriptionsSymptomatic seizuresAntiseizure medicationsElectrographic seizuresContinuous electroencephalographyOdds of treatmentGlasgow Outcome Scale scoreNeurological intensive care unitOptimal treatment durationMulticenter cohort studyAntiseizure medication useOutcome Scale scorePrescribed antiseizure medicationsAssociated with functional outcomeIntensive care unitAssociated with outcomeMain OutcomesProgressive brain injuryASM treatmentMedication useCohort studyEpileptiform abnormalitiesAntiseizure Medication Withdrawal, Risk of Epilepsy, and Longterm EEG Trends in Acute Symptomatic Seizures or Epileptic EEG Patterns.
Sivaraju A, Tao A, Jadav R, Kirunda K, Rampal N, Kim J, Gilmore E, Hirsch L. Antiseizure Medication Withdrawal, Risk of Epilepsy, and Longterm EEG Trends in Acute Symptomatic Seizures or Epileptic EEG Patterns. Neurology Clinical Practice 2024, 14: e200342. PMID: 39185097, PMCID: PMC11341085, DOI: 10.1212/cpj.0000000000200342.Peer-Reviewed Original ResearchCombined neuromodulation and resection for functional cortex epilepsy: a case series.
Merenzon M, Sivaraju A, Herlopian A, Gerrard J, Quraishi I, Hirsch L, Spencer D, Damisah E. Combined neuromodulation and resection for functional cortex epilepsy: a case series. Journal Of Neurosurgery 2024, 141: 1527-1535. PMID: 38848588, DOI: 10.3171/2024.3.jns24122.Peer-Reviewed Original ResearchConceptsMedically refractory epilepsySeizure onset zoneFunctional cortexSeizure outcomeRefractory epilepsyMonths of follow-up dataMaximal safe resectionMedian follow-upTreated with resectionImprove seizure outcomeFocal neuromodulationFollow-up dataPreservation of functionRetrospective analysis of individualsSafe resectionPartial resectionMedian intervalCase seriesPreoperative assessmentSurgical interventionRNS deviceNeurological deficitsNo significant changesResectionRetrospective analysis
Academic Achievements & Community Involvement
honor American Epilepsy Society Infrastructure Grant
National AwardAESDetails07/01/2021honor Swebilious Foundation Grant
Yale School of Medicine AwardSwebilious Foundation, YaleDetails08/01/2019honor Young Investigator Award
National AwardAmerican Clinical Neurophysiological Society (ACNS)Details02/09/2015United States
Clinical Care
Overview
Adithya Sivaraju, MD, MHA, specializes in treating patients with epilepsy and a range of other neurological conditions, including stroke, immunologic disorders and infections. He is actively involved in researching the best approaches to epilepsy surgery and optimization of techniques used to evaluate the brain’s electrical activity. “It means a lot to us when we are able to finally do something about these problems,” he says. “Anytime we can make patients seizure-free through epilepsy surgery it is a remarkable feeling.”
An assistant professor of neurology at Yale School of Medicine, Dr. Sivaraju says he joined the faculty because he was drawn to what he saw as an environment “rich in the exchange of knowledge and opportunities for research collaboration.”
He is determined to continue searching for the cause of seizures and how to best treat them. “With that question left unanswered, there is never a dull moment or lack of motivation to keep working at it and finding answers,” he says.
Clinical Specialties
Fact Sheets
Epilepsy
Learn More on Yale MedicineEpilepsy in Children and Teens
Learn More on Yale MedicinePediatric Sepsis
Learn More on Yale MedicineSyncope
Learn More on Yale Medicine
Board Certifications
Epilepsy
- Certification Organization
- AB of Psychiatry & Neurology
- Latest Certification Date
- 2017
- Original Certification Date
- 2017
Neurology
- Certification Organization
- AB of Psychiatry & Neurology
- Original Certification Date
- 2013
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