2022
A new lineage of Galapagos giant tortoises identified from museum samples
Jensen E, Quinzin M, Miller J, Russello M, Garrick R, Edwards D, Glaberman S, Chiari Y, Poulakakis N, Tapia W, Gibbs J, Caccone A. A new lineage of Galapagos giant tortoises identified from museum samples. Heredity 2022, 128: 261-270. PMID: 35217806, PMCID: PMC8987048, DOI: 10.1038/s41437-022-00510-8.Peer-Reviewed Original ResearchConceptsGalapagos giant tortoisesMitochondrial control regionGiant tortoisesSingle nucleotide polymorphismsControl regionMuseum samplesGenome-wide single nucleotide polymorphismsDivergent mitochondrial lineagesSingle mitochondrial haplotypeContemporary populationsIconic radiationMitochondrial lineagesAdditional lineagesMitochondrial haplotypesNuclear markersSan CristóbalSecond lineageMicrosatellite lociNew lineagePinta IslandSame cladeEvolutionary processesLineagesGalapagos ArchipelagoEarly evolution
2021
Four times out of Europe: Serial invasions of the winter moth, Operophtera brumata, to North America
Andersen J, Havill N, Caccone A, Elkinton J. Four times out of Europe: Serial invasions of the winter moth, Operophtera brumata, to North America. Molecular Ecology 2021, 30: 3439-3452. PMID: 34033202, DOI: 10.1111/mec.15983.Peer-Reviewed Original ResearchConceptsWinter mothNortheastern United StatesNorth AmericaInvasive winter mothNon-native speciesPopulation genetic dataAmount of diversityInvasion successSerial invasionInvaded regionsWidespread defoliationGenetic bottleneckBayesian assignmentOperophtera brumataMicrosatellite lociApproximate Bayesian computation methodsIndependent introductionsNorthern FennoscandiaCentral EuropeGenetic dataHybridization eventsBritish ColumbiaGeographic originNova ScotiaAmericaA machine learning approach to integrating genetic and ecological data in tsetse flies (Glossina pallidipes) for spatially explicit vector control planning
Bishop AP, Amatulli G, Hyseni C, Pless E, Bateta R, Okeyo WA, Mireji PO, Okoth S, Malele I, Murilla G, Aksoy S, Caccone A, Saarman NP. A machine learning approach to integrating genetic and ecological data in tsetse flies (Glossina pallidipes) for spatially explicit vector control planning. Evolutionary Applications 2021, 14: 1762-1777. PMID: 34295362, PMCID: PMC8288027, DOI: 10.1111/eva.13237.Peer-Reviewed Original ResearchGenetic dataVectors of humanLake Victoria basinAnimal African trypanosomiasisGenetic connectivityVector-borne disease transmissionFuture monitoring effortsMicrosatellite lociHabitat useImportant environmental predictorsHabitat suitabilityFuture climatic changesDispersal patternsVictoria basinEcological dataEnvironmental predictorsVector systemTsetse fliesTsetse speciesClimatic shiftsFliesClimatic changesSampling sitesMonitoring effortsVector control
2019
Widespread hybridization among native and invasive species of Operophtera moths (Lepidoptera: Geometridae) in Europe and North America
Andersen J, Havill N, Broadley H, Boettner G, Caccone A, Elkinton J. Widespread hybridization among native and invasive species of Operophtera moths (Lepidoptera: Geometridae) in Europe and North America. Biological Invasions 2019, 21: 3383-3394. DOI: 10.1007/s10530-019-02054-1.Peer-Reviewed Original ResearchWinter mothNorth AmericaBruce spanwormInvasive winter mothWsp gene fragmentsCytochrome oxidase I.Polymorphic microsatellite lociNortheastern United StatesNative congenerInvasive speciesWidespread hybridizationGeographic extentCrop systemsField-collected mothsPresence of WolbachiaMoth individualsMicrosatellite lociHybrid individualsPCR amplificationSpeciesAmericaGene fragmentsMothBritish ColumbiaNova Scotia
2018
Genetic Differentiation of Glossina pallidipes Tsetse Flies in Southern Kenya.
Okeyo WA, Saarman NP, Bateta R, Dion K, Mengual M, Mireji PO, Ouma C, Okoth S, Murilla G, Aksoy S, Caccone A. Genetic Differentiation of Glossina pallidipes Tsetse Flies in Southern Kenya. American Journal Of Tropical Medicine And Hygiene 2018, 99: 945-953. PMID: 30105964, PMCID: PMC6159567, DOI: 10.4269/ajtmh.18-0154.Peer-Reviewed Original ResearchConceptsGenetic differentiationPopulation dynamicsDispersal patternsTsetse fliesLow genetic diversityGreater genetic differentiationEvidence of admixtureWestern clusterEastern clusterRecent anthropogenic influencesAnimal African trypanosomiasisGenetic connectivityWestern relativesGenetic diversityMicrosatellite lociPopulation structureGenotypic dataWidespread signalDisease vectorsMajor vectorVector control effortsGreat Rift ValleyDemographic parametersFliesVector control programsGenome-Wide Assessment of Diversity and Divergence Among Extant Galapagos Giant Tortoise Species
Miller J, Quinzin M, Edwards D, Eaton D, Jensen E, Russello M, Gibbs J, Tapia W, Rueda D, Caccone A. Genome-Wide Assessment of Diversity and Divergence Among Extant Galapagos Giant Tortoise Species. Journal Of Heredity 2018, 109: 611-619. PMID: 29986032, DOI: 10.1093/jhered/esy031.Peer-Reviewed Original ResearchConceptsGiant tortoise speciesMitochondrial DNA sequencesSingle nucleotide polymorphismsTortoise speciesGenetic diversityMicrosatellite lociDNA sequencesGenotypic dataMicrosatellite genotypic dataNuclear microsatellite lociGenome-wide markersEstimates of diversityGenome-wide assessmentGalapagos giant tortoisesSpecies radiationEvolutionary geneticsSignificant unitsMitochondrial DNAPopulation structureSpecies conservationGenetic lineagesGiant tortoisesPopulation delineationTortoise populationsDNA sequencing
2017
Genetic diversity of Glossina fuscipes fuscipes along the shores of Lake Victoria in Tanzania and Kenya: implications for management
Manangwa O, Nkwengulila G, Ouma JO, Mramba F, Malele I, Dion K, Sistrom M, Khan F, Aksoy S, Caccone A. Genetic diversity of Glossina fuscipes fuscipes along the shores of Lake Victoria in Tanzania and Kenya: implications for management. Parasites & Vectors 2017, 10: 268. PMID: 28558831, PMCID: PMC5450392, DOI: 10.1186/s13071-017-2201-x.Peer-Reviewed Original ResearchGenetic diversity and population structure of the tsetse fly Glossina fuscipes fuscipes (Diptera: Glossinidae) in Northern Uganda: Implications for vector control
Opiro R, Saarman NP, Echodu R, Opiyo EA, Dion K, Halyard A, Dunn AW, Aksoy S, Caccone A. Genetic diversity and population structure of the tsetse fly Glossina fuscipes fuscipes (Diptera: Glossinidae) in Northern Uganda: Implications for vector control. PLOS Neglected Tropical Diseases 2017, 11: e0005485. PMID: 28453513, PMCID: PMC5425221, DOI: 10.1371/journal.pntd.0005485.Peer-Reviewed Original ResearchConceptsAnimal African trypanosomiasisGenetic clustersEffective population size estimatesLake KyogaRecent population bottleneckMitochondrial DNA markersDistinct genetic clustersPolymorphic microsatellite lociNile drainagePopulation size estimatesGenetic structurePopulation bottlenecksMain haplogroupsGenetic diversityMicrosatellite lociGenetic assignmentDNA markersPopulation structureMtDNA analysisGenetic admixtureSampling sitesGenetic unitsMost populationsTrypanosoma parasitesHuman African trypanosomiasisPostglacial recolonization shaped the genetic diversity of the winter moth (Operophtera brumata) in Europe
Andersen J, Havill N, Caccone A, Elkinton J. Postglacial recolonization shaped the genetic diversity of the winter moth (Operophtera brumata) in Europe. Ecology And Evolution 2017, 7: 3312-3323. PMID: 28515868, PMCID: PMC5433974, DOI: 10.1002/ece3.2860.Peer-Reviewed Original ResearchDistinct glacial refugiaWinter mothPostglacial recolonizationGene flowGlacial refugiaGenetic diversityOngoing gene flowObserved genetic patternsQuaternary climatic oscillationsLong-distance dispersalResult of dispersalPolymorphic microsatellite lociMajor genetic clustersNorthern puritySouthern richnessSecondary contactHybrid zoneSpecies diversityNorthern populationsSouthern populationsGenetic clustersMicrosatellite lociWestern PalearcticGenetic lineagesGenetic patterns
2016
Asymmetric hybridization between non-native winter moth, Operophtera brumata (Lepidoptera: Geometridae), and native Bruce spanworm, Operophtera bruceata, in the Northeastern United States, assessed with novel microsatellites and SNPs
Havill N, Elkinton J, Andersen J, Hagen S, Broadley H, Boettner G, Caccone A. Asymmetric hybridization between non-native winter moth, Operophtera brumata (Lepidoptera: Geometridae), and native Bruce spanworm, Operophtera bruceata, in the Northeastern United States, assessed with novel microsatellites and SNPs. Bulletin Of Entomological Research 2016, 107: 241-250. PMID: 27876095, DOI: 10.1017/s0007485316000857.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsMicrosatellite lociBruce spanwormAsymmetric hybridizationWinter mothSpecies-diagnostic single nucleotide polymorphismsOperophtera brumataVariable microsatellite lociNon-native pestsTypes of markersBacterial symbiontsGenetic incompatibilitiesGenomic approachesLaboratory crossesNative speciesAsymmetrical hybridizationPopulation geneticsPutative hybridsHybrid backcrossesNovel microsatellitesForest treesOperophtera bruceataO. bruceataReciprocal crossesGenetic markers
2015
Naturally rare versus newly rare: demographic inferences on two timescales inform conservation of Galápagos giant tortoises
Garrick R, Kajdacsi B, Russello M, Benavides E, Hyseni C, Gibbs J, Tapia W, Caccone A. Naturally rare versus newly rare: demographic inferences on two timescales inform conservation of Galápagos giant tortoises. Ecology And Evolution 2015, 5: 676-694. PMID: 25691990, PMCID: PMC4328771, DOI: 10.1002/ece3.1388.Peer-Reviewed Original ResearchGalápagos giant tortoisesDeep timescalesDemographic historyGiant tortoisesLocal effective population sizeLong-term population historyPopulation sizeMitochondrial control regionEffective population sizeAnalysis of genotypicLevel of variationShallow timescalesNuclear intronsRecent bottleneckGenetic bottleneckCensus sizeNeutral markersPhylogenetic informationIsland ageMicrosatellite lociDemographic inferenceGenetic estimatesControl regionPopulation historyConservation perspective
2014
Cryptic structure and niche divergence within threatened Galápagos giant tortoises from southern Isabela Island
Edwards D, Garrick R, Tapia W, Caccone A. Cryptic structure and niche divergence within threatened Galápagos giant tortoises from southern Isabela Island. Conservation Genetics 2014, 15: 1357-1369. DOI: 10.1007/s10592-014-0622-z.Peer-Reviewed Original ResearchSouthern Isabela IslandGalápagos giant tortoisesGenetic clustersIsabela IslandGiant tortoisesMorphological diversityRecent gene flowBiodiversity lossConservation managementEcological divergenceSignificant unitsNiche divergenceFeral animalsEcological factorsGenetic differentiationEcological nichesGene flowCryptic structureMicrosatellite lociManagement successSpatial distributionCurrent taxonomyTortoisesManagement programDiversity
2013
Urban population genetics of slum‐dwelling rats (Rattus norvegicus) in Salvador, Brazil
Kajdacsi B, Costa F, Hyseni C, Porter F, Brown J, Rodrigues G, Farias H, Reis MG, Childs JE, Ko AI, Caccone A. Urban population genetics of slum‐dwelling rats (Rattus norvegicus) in Salvador, Brazil. Molecular Ecology 2013, 22: 5056-5070. PMID: 24118116, PMCID: PMC3864905, DOI: 10.1111/mec.12455.Peer-Reviewed Original ResearchConceptsGenetic structurePopulation genetic structureComplex genetic structureSmall geographical distancesGene flowGenetic clustersGenetic diversityMicrosatellite lociPopulation geneticsUrban landscapeGenetic variationPopulation ecologyGenetic dataHeterogeneous urban landscapesDistinct sampling sitesGeographical distanceRodent control measuresRodent control strategiesZoonotic pathogensR. norvegicusSampling sitesSpatial connectivityRat populationsOvergrown vegetationBayesian analysisGeographic population structure of the African malaria vector Anopheles gambiae suggests a role for the forest‐savannah biome transition as a barrier to gene flow
J P, A E, JL V, B G, F S, M M, JD C, F S, N E, D W, MJ D, A C, A D. Geographic population structure of the African malaria vector Anopheles gambiae suggests a role for the forest‐savannah biome transition as a barrier to gene flow. Evolutionary Applications 2013, 6: 910-924. PMID: 24062800, PMCID: PMC3779092, DOI: 10.1111/eva.12075.Peer-Reviewed Original ResearchGene flowPopulation structurePopulation substructureAfrican malaria vector Anopheles gambiaeMalaria vector Anopheles gambiaeGeographic population structureComplex population structureChromosomal arrangementsBiome transitionsGenetic clustersMicrosatellite lociAnopheles gambiae sensu strictoGambiae sensu strictoAnopheles gambiaeSensu strictoRainforest beltDistinct westAdditional populationsS formMolecular formsGambiaeBiomeLociSpeciesStricto
2012
Limited Usefulness of Microsatellite Markers from the Malaria Vector Anophelesgambiae When Applied to the Closely Related Species Anopheles melas
Deitz K, Reddy V, Reddy M, Satyanarayanah N, Lindsey M, Overgaard H, Jawara M, Caccone A, Slotman M. Limited Usefulness of Microsatellite Markers from the Malaria Vector Anophelesgambiae When Applied to the Closely Related Species Anopheles melas. Journal Of Heredity 2012, 103: 585-593. PMID: 22593601, DOI: 10.1093/jhered/ess025.Peer-Reviewed Original Research
2011
Isolation of 13 novel highly polymorphic microsatellite loci for the Amazonian Palm Mauritia flexuosa L.f. (Arecaceae)
Federman S, Hyseni C, Clement W, Caccone A. Isolation of 13 novel highly polymorphic microsatellite loci for the Amazonian Palm Mauritia flexuosa L.f. (Arecaceae). Conservation Genetics Resources 2011, 4: 355-357. DOI: 10.1007/s12686-011-9547-8.Peer-Reviewed Original ResearchPolyandry Is a Common Event in Wild Populations of the Tsetse Fly Glossina fuscipes fuscipes and May Impact Population Reduction Measures
Bonomi A, Bassetti F, Gabrieli P, Beadell J, Falchetto M, Scolari F, Gomulski LM, Regazzini E, Ouma JO, Caccone A, Okedi LM, Attardo GM, Guglielmino CR, Aksoy S, Malacrida AR. Polyandry Is a Common Event in Wild Populations of the Tsetse Fly Glossina fuscipes fuscipes and May Impact Population Reduction Measures. PLOS Neglected Tropical Diseases 2011, 5: e1190. PMID: 21666797, PMCID: PMC3110164, DOI: 10.1371/journal.pntd.0001190.Peer-Reviewed Original ResearchConceptsEffective population sizePopulation sizeInformative microsatellite lociNumber of matingsTsetse Fly GlossinaFemale rematingWild populationsReproductive biologyMicrosatellite lociFemale matesSterile malesDifferent matesFemale spermathecaeRematingReproductive potentialPolyandryDirect countsPopulation age structureFuscipesLake VictoriaSpermathecaeWildMatesDry seasonSpeciesTemporal stability of Glossina fuscipes fuscipes populations in Uganda
Echodu R, Beadell JS, Okedi LM, Hyseni C, Aksoy S, Caccone A. Temporal stability of Glossina fuscipes fuscipes populations in Uganda. Parasites & Vectors 2011, 4: 19. PMID: 21320301, PMCID: PMC3045980, DOI: 10.1186/1756-3305-4-19.Peer-Reviewed Original ResearchConceptsEffective population size estimatesMitochondrial haplotype frequenciesEstimates of differentiationZone of contactJost's DESTPopulation size estimatesMitochondrial lociMating compatibilityMicrosatellite frequenciesMicrosatellite lociRiverine speciesPopulation dynamicsGenetic changesObserved seasonal fluctuationsHuman African trypanosomiasisMajor vectorSingle populationG. fuscipesTsetse fliesFuscipesAllele frequenciesHaplotype frequenciesLociSeasonal fluctuationsTime of sampling
2010
Population Genetic Structure of Aldabra Giant Tortoises
Balmer O, Ciofi C, Galbraith D, Swingland I, Zug G, Caccone A. Population Genetic Structure of Aldabra Giant Tortoises. Journal Of Heredity 2010, 102: 29-37. PMID: 20805288, DOI: 10.1093/jhered/esq096.Peer-Reviewed Original ResearchConceptsGenetic structurePopulation structureGiant tortoisesMitochondrial DNA control region sequencesPopulation genetic structureSignificant population structureControl region sequencesAldabra giant tortoisePrevious ecological studiesAllopatric divergenceNuclear lociPopulation subdivisionHabitat variationMtDNA sequencesMicrosatellite lociPopulation geneticsUnsuitable habitatGenetic variabilityAllelic variationRegion sequencesEcological factorsTerrestrial ecosystemsPopulation dynamicsAldabra AtollGeographical barriersGenetic Differentiation between Marine Iguanas from Different Breeding Sites on the Island of Santa Fé (Galápagos Archipelago)
Lanterbecq D, Glaberman S, Vitousek M, Steinfartz S, Benavides E, Wikelski M, Caccone A. Genetic Differentiation between Marine Iguanas from Different Breeding Sites on the Island of Santa Fé (Galápagos Archipelago). Journal Of Heredity 2010, 101: 663-675. PMID: 20538757, DOI: 10.1093/jhered/esq067.Peer-Reviewed Original ResearchConceptsMarine iguanasGenetic diversitySex-biased dispersalMitochondrial control regionMitochondrial DNA markersGalápagos marine iguanasSanta FéDifferent breeding sitesSouthern sitesGenetic differentiationEvolutionary signalGenetic structureMicrosatellite lociDNA markersControl regionGenetic variationGenetic patternsBreeding sitesLittle differentiationBase pairsNeighboring islandsIguanasDiversitySampling sitesDifferentiation