Genetic variation in endocannabinoid signaling is associated with differential network‐level functional connectivity in youth
Sisk LM, Rapuano KM, Conley MI, Greene AS, Horien C, Rosenberg MD, Scheinost D, Constable RT, Glatt CE, Casey BJ, Gee DG. Genetic variation in endocannabinoid signaling is associated with differential network‐level functional connectivity in youth. Journal Of Neuroscience Research 2021, 100: 731-743. PMID: 34496065, PMCID: PMC8866205, DOI: 10.1002/jnr.24946.Peer-Reviewed Original ResearchConceptsEndocannabinoid signalingAllele carriersLower anxiety symptomsC385A polymorphismNetwork-level functional connectivityEnhanced endocannabinoid signalingLarge-scale resting-state brain networksAnxiety symptomsResting-state brain networksGenotype-associated differencesBrain networksFronto-amygdala connectivityFunctional connectionsCognitive Development StudyNetwork-level changesPotential protective factorsAdolescent Brain Cognitive Development (ABCD) studyEndocannabinoid systemNetwork-level differencesYounger ageFunctional connectivityProtective factorsNeural phenotypesAnxiety disordersNeural connectivityUsing functional connectivity models to characterize relationships between working and episodic memory
Stark GF, Avery EW, Rosenberg MD, Greene AS, Gao S, Scheinost D, Constable R, Chun MM, Yoo K. Using functional connectivity models to characterize relationships between working and episodic memory. Brain And Behavior 2021, 11: e02105. PMID: 34142458, PMCID: PMC8413720, DOI: 10.1002/brb3.2105.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelsN-back task performanceEpisodic memoryMemory test scoresFunctional connectivityTask performanceN-back memory taskWord scoresTest scoresCritical cognitive abilityPicture-sequencing taskHuman Connectome Project participantsN-back taskFunctional magnetic resonance imaging (fMRI) dataWhole-brain functional connectivityTask functional connectivityFunctional brain connectionsFunctional connectivity modelsFunctional connectionsMemory taskCognitive processesMemory testCognitive abilitiesSequence taskList Sorting