Skip to Main Content

INFORMATION FOR

    Yale Urology Research [Q4: October-December 2024]

    January 16, 2025

    The following is a comprehensive list of Yale Urology publications/presentations for the fourth quarter of calendar year 2024. The listing is in descending published date order and features primary faculty, trainee, and care team work. Each item includes links to the full study or presentation and provides portions of the abstract / summary.

    Turk Yilmaz RS, Hittelman AB, Vash-Margita A, Dinauer C, Weinzimer SA, Gujral J. An Infant With DHX37 Variant: A Novel Etiology of 46,XY DSD and Literature Review. JCEM Case Rep. 2024 Dec 26;3(1):luae239. doi: 10.1210/jcemcr/luae239. PMID: 39726663; PMCID: PMC11669865.

    46,XY sex reversal 11 (SRXY11) is a rare and recently identified form of 46,XY difference in sexual development (DSD), caused by variants in the DEAH-Box Helicase 37 gene (DHX37). We present a 46,XY infant with prenatal ultrasound findings of atypical genitalia.


    Shah YB, Lokeshwar SD, Brutus N, Sterling J. Rectourethral fistula after perirectal spacer placement requiring pelvic exenteration. BMJ Case Rep. 2024 Dec 24;17(12):e263333. doi: 10.1136/bcr-2024-263333. PMID: 39719384.

    This case report details a severe complication of rectourethral fistula necessitating robotic pelvic exenteration with urinary and faecal diversion following perirectal spacer placement.


    Sundaresan VM, Webb L, Rabil M, Golos A, Sutherland R, Bailey J, Rajwa P, Seibert TM, Loeb S, Cooperberg MR, Catalona WJ, Sprenkle PC, Kim IY, Leapman MS. Risks of grade reclassification among patients with Gleason grade group 1 prostate cancer and PI-RADS 5 findings on prostate MRI. Urol Oncol. 2024 Dec 19:S1078-1439(24)00723-3. doi: 10.1016/j.urolonc.2024.11.007. Epub ahead of print. PMID: 39706698.

    We conducted a single-institution retrospective analysis to identify patients with GG1 prostate cancer on fusion biopsy with MRI demonstrating ≥1 PI-RADS 5 lesion.


    Taylor J, Kamat AM, Annapureddy D, Khene ZE, Howard J, Tan WS, McElree IM, Facundo D, Yim K, Harrington S, Dyer E, Black AJ, Kanabur P, Roumiguié M, Lerner S, Black PC, Raman J, Preston M, Steinberg G, Huang W, Li R, Packiam VT, Woldu SL, Lotan Y, O'Donnell MA. Oncologic Outcomes of Sequential Intravesical Gemcitabine and Docetaxel Compared with Bacillus Calmette-Guérin in Patients with Bacillus Calmette-Guérin-Unresponsive Non-Muscle Invasive Bladder Cancer. Eur Urol Oncol. 2024 Dec 17:S2588-9311(24)00288-8. doi: 10.1016/j.euo.2024.12.005. Epub ahead of print. PMID: 39694798.

    This study aims to compare oncologic outcomes between sequential intravesical gem/doce versus additional BCG in patients with BCG-unresponsive NMIBC.


    Ajjawi I, Loeb S, Cooperberg MR, Catalona WJ, Gross CP, Ma X, Leapman MS. Active Surveillance or Watchful Waiting for Intermediate-Risk Prostate Cancer, 2010-2020. JAMA. 2024 Dec 17;332(23):2033-2036. doi: 10.1001/jama.2024.20580. PMID: 39565605; PMCID: PMC11579888.

    This cross-sectional study evaluates trends and factors associated with selecting active surveillance or watchful waiting among individuals with intermediate-risk prostate cancer.


    Leapman MS. Editorial Comment on "Commercial Prices and Care for Medicare Beneficiaries With Prostate Cancer. Urology. 2024 Dec 16:S0090-4295(24)01140-3. doi: 10.1016/j.urology.2024.12.010. Epub ahead of print. PMID: 39694100.

    Rapid consolidation in healthcare is likely to further impact healthcare costs, with still undefined effects on care quality and outcomes.


    [Onofrey J] Rate-in: Information-driven adaptive dropout rates for improved inference-time uncertainty estimation. arXiv. 2024. doi:10.48550/arxiv.2412.07169. arXiv ID: arXiv:2412.07169.

    In this paper, we propose Rate-In, an algorithm that dynamically adjusts dropout rates during inference by quantifying the information loss induced by dropout in each layer’s feature maps.


    Kuhn TN, Engelhardt WD, Kahl VH, Alkukhun A, Gross M, Iseke S, Onofrey J, Covey A, Camacho Vasquez JC, Kawaguchi Y, Hasegawa K, Odisio BC, Vauthey JN, Antoch G, Chapiro J, Madoff DC. AI-driven Patient-Selection For Preoperative Portal Vein Embolization For Patients With Colorectal Cancer Liver Metastases. J Vasc Interv Radiol. 2024 Dec 3:S1051-0443(24)00749-8. doi: 10.1016/j.jvir.2024.11.025. Epub ahead of print. PMID: 39638087.

    This multicenter retrospective study (2000-2020) included 200 consecutive patients with CRC liver-metastases planned for PVE before surgery.


    Schultz KS, Butensky SD, Hickey TR, Ahuja V, Perkal MF, Murthy SS, Cavallo JA, Leeds IL. Evaluating the Safety of Empiric Tamsulosin to Prevent Postoperative Urinary Retention in a Colorectal Surgery Recovery Pathway. Ann Surg Open. 2024 Nov 6;5(4):e511. doi: 10.1097/AS9.0000000000000511. PMID: 39711672; PMCID: PMC11661766.

    The purpose of this study was to evaluate the safety of empiric tamsulosin in male veterans undergoing major colorectal surgery.


    [Onofrey J]. CT-less whole-body bone segmentation of PET images using a multimodal deep learning network. IEEE journal of biomedical and health informatics. 2024;PP(99):1-16. doi: 10.1109/jbhi.2024.3501386.

    In this work, we propose a novel multimodal fusion network (MMF-Net) for WBBS of PET images, without the need for CT images.


    Jalilianhasanpour R, Arora S, Mansoori B, Raman S, Greenwood BM, Sprenkle P, Schade G, Camacho M, Hosseini N, Westphalen A. MRI after focal therapy for prostate cancer: what radiologists must know? Abdom Radiol (NY). 2024 Nov 15. doi: 10.1007/s00261-024-04670-5. Epub ahead of print. PMID: 39542951.

    This article reviews the currently available prostate cancer FT techniques, discusses the key imaging findings that affect patient selection and treatment planning, and illustrates the spectrum of expected and abnormal post-treatment MRI findings.


    Lokeshwar SD, Choksi AU, Smani S, Kong V, Sundaresan V, Sutherland R, Brito J, Renzulli JF, Sprenkle PC, Leapman MS. Pathologic prostate cancer grade concordance among high-resolution micro-ultrasound, systematic transrectal ultrasound and MRI fusion biopsy. Urol Oncol. 2024 Nov 8:S1078-1439(24)00698-7. doi:10.1016/j.urolonc.2024.10.018. Epub ahead of print. PMID: 39521675.

    We compared GG-upgrade from biopsy to RP based on highest GG in any biopsy core and examined clinical/pathologic factors associated with pathologic upgrading using descriptive statistics, and multivariable logistic-regression analysis.


    Moore CL, Gross CP, Hart L, Molinaro AM, Rhodes D, Singh D, Baloescu C. Construction and performance of a clinical prediction rule for ureteral stone without the use of race or ethnicity: A new STONE score. J Am Coll Emerg Physicians Open. 2024 Nov 7;5(6):e13324. doi: 10.1002/emp2.13324. PMID: 39524039; PMCID: PMC11543628.

    With recent increased awareness of the potential adverse impacts of including race (a socially constructed identity) in clinical prediction rules, we sought to determine if a revised STONE score without race could be constructed with similar diagnostic accuracy.


    Cross JL, Choma MA, Onofrey JA. Bias in medical AI: Implications for clinical decision-making. PLOS Digit Health. 2024 Nov 7;3(11):e0000651. doi: 10.1371/journal.pdig.0000651. PMID: 39509461; PMCID: PMC11542778.

    We discuss potential biases that can arise at different stages in the AI development pipeline and how they can affect AI algorithms and clinical decision-making.


    [Onofrey J]. Data-driven non-rigid motion detection and correction for NeuroEXPLORER. 2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD). 10/2024:1-2. doi: 10.1109/nss/mic/rtsd57108.2024.10658289

    In this study, we introduced a data-driven non-rigid motion correction framework for the NX (NX-NRMC) to address non-rigid motions and assessed the effectiveness of UMT-derived rigid motion data in non-rigid regions.


    Washington Iii SL, Fakunle M, Wang L, Braun AE, Leapman M, Cowan JE, Cooperberg MR. County-level racial disparities in prostate cancer-specific mortality from 2005 to 2020. JNCI Cancer Spectr. 2024 Nov 1;8(6):pkae109. doi: 10.1093/jncics/pkae109. PMID: 39495143; PMCID: PMC11631307.

    Local conditions where people live continue to influence prostate cancer outcomes. By examining local characteristics associated with trends in Black-White differences in prostate cancer-specific mortality over time, we aim to identify factors driving county-level prostate cancer-specific mortality disparities over a 15-year period.


    Rahman SN, Kim HS, Webb LT, Diaz GM, Leapman MS, Sprenkle PC, Brito JM, Renzulli J, Martin TV, Kenney P, Kim IY. Management strategies for radio-recurrent prostate cancer: a comprehensive review. Transl Cancer Res. 2024 Nov 30;13(11):6473-6488. doi: 10.21037/tcr-24-245. Epub 2024 Jul 16. PMID: 39697737; PMCID: PMC11651831.

    This comprehensive review aims to examine the current landscape of therapeutic approaches and emerging strategies for managing radio-recurrent prostate cancer.


    Gaylis FD, Leapman MS, Ellis SD, Hu S, Cooperberg MR, Loeb S, Chen RC, Cohen ES, Dato PE, Aynehchi S, David R, Topp R, Santomauro B, Ginsburg K, Catalona WJ. Feasibility of Pay for Performance and Transparency Interventions on the Selection and Quality of Observational Management for Patients with Low-Risk Prostate Cancer in the Community Practice. Urol Pract. 2024 Oct 25:101097UPJ0000000000000745. doi: 10.1097/UPJ.0000000000000745. Epub ahead of print. PMID: 39453985.


    Dong S, Cai Z, Hangel G, Bogner W, Widhalm G, Huang Y, Liang Q, You C, Kumaragamage C, Fulbright RK, Mahajan A, Karbasi A, Onofrey JA, de Graaf RA, Duncan JS. A Flow-based Truncated Denoising Diffusion Model for super-resolution Magnetic Resonance Spectroscopic Imaging. Med Image Anal. 2025 Jan;99:103358. doi: 10.1016/j.media.2024.103358. Epub 2024 Sep 27. PMID: 39353335; PMCID: PMC11609020.

    This work introduces a Flow-based Truncated Denoising Diffusion Model (FTDDM) for super-resolution MRSI, which shortens the diffusion process by truncating the diffusion chain, and the truncated steps are estimated using a normalizing flow-based network.


    Kim WT, Kim K, Kang HW, Byun YJ, Piao XM, Kim YJ, Lee SC, Yun SJ, Ha YS, Kim J, Kim IY. Single‑center, retrospective, evaluator‑blinded, pilot and pivotal clinical trials: Assessing the mirCaP Kit (hsv2‑miR‑H9/hsa‑miR‑3659) as a diagnostic marker for prostate cancer in patients with PSA levels in the gray zone. Oncol Lett. 2024 Oct 23;29(1):23. doi: 10.3892/ol.2024.14770. PMID: 39512501; PMCID: PMC11542165.

    In the present study, a single-center, retrospective, evaluator-blinded, pilot and pivotal clinical trial was performed to assess the clinical performance of the mirCaP kit (Urotech, Inc.), which measures the herpes simplex virus 2-microRNA (miR)-H9/hsa-miR-3659 ratio, with respect to helping physicians make appropriate decisions regarding further assessment of patients with PSA levels within this gray zone.


    Smani S, Jalfon M, Sundaresan V, Lokeshwar SD, Nguyen J, Halstuch D, Khajir G, Cavallo JA, Sprenkle PC, Leapman MS, Kim IY. Inter-reader reliability and diagnostic accuracy of PI-RADS scoring between academic and community care networks: How wide is the gap? Urol Oncol. 2024 Oct 21:S1078-1439(24)00681-1. doi: 10.1016/j.urolonc.2024.10.002. Epub ahead of print. PMID: 39438211.

    To assess variability in mpMRI interpretation and reporting of PCa, we evaluated the discrepancies in PI-RADS scoring between community practices and a tertiary academic care center.


    Mandino F, Shen X, Desrosiers-Grégoire G, O'Connor D, Mukherjee B, Owens A, Qu A, Onofrey J, Papademetris X, Chakravarty MM, Strittmatter SM, Lake EMR. Aging-dependent loss of functional connectivity in a mouse model of Alzheimer's disease and reversal by mGluR5 modulator. Mol Psychiatry. 2024 Oct 18. doi: 10.1038/s41380-024-02779-z. Epub ahead of print. PMID: 39424929.

    Here, we conduct a longitudinal study in a double knock-in mouse model for AD (AppNL-G-F/hMapt), monitoring brain connectivity by means of resting-state fMRI.


    Fazekas T, Pallauf M, Kufel J, Miszczyk M, Tsuboi I, Matsukawa A, Laukhtina E, Kardoust Parizi M, Mancon S, Cadenar A, Schulz R, Yanagisawa T, Baboudjian M, Szarvas T, Gandaglia G, Tilki D, Nyirády P, Rajwa P, Leapman MS, Shariat SF. Molecular Correlates of Prostate Cancer Visibility on Multiparametric Magnetic Resonance Imaging: A Systematic Review. Eur Urol Oncol. 2024 Oct 15:S2588-9311(24)00227-X. doi: 10.1016/j.euo.2024.09.017. Epub ahead of print. PMID: 39414421.

    Our aim was to examine the existing knowledge regarding the molecular correlates of MRI visibility of PCa.


    Camenga DR, Brady SS, Bilger A, Klusaritz H, Lipman TH, Levin EC, Brown O, Cunningham SD, LaCoursiere DY, James AS, Gahagan S, Hebert-Beirne J, Low LK, [Rickey LM]; Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium. Bladder Health Knowledge, Attitudes, and Beliefs among US Adolescent Women. J Pediatr Adolesc Gynecol. 2024 Oct 5:S1083-3188(24)00299-7. doi: 10.1016/j.jpag.2024.09.008. Epub ahead of print. PMID: 39374689.

    This study combines data from two large multi-site focus group studies of individuals born female, who identified as women, conducted by the Prevention of Lower Urinary Tract Symptoms Research Consortium.


    Smani S, Gardezi M, Laditi F, Sundaresan VM, Kong V, Olawoyin O, Casilla-Lennon M. Implementation of a Urologic Surgery Skills Fair for Medical Students. J Surg Educ. 2024 Dec;81(12):103300. doi: 10.1016/j.jsurg.2024.103300. Epub 2024 Oct 4. PMID: 39368323.

    To increase the proportion of applicants to urology residencies, we created a surgical skills fair to introduce urology early in undergraduate medical education.


    Kunst N, Long JB, Westvold S, Sprenkle PC, Kim IY, Saperstein L, Rabil M, Ghaffar U, Karnes RJ, Ma X, Gross CP, Wang SY, Leapman MS. Long-Term Outcomes of Prostate-Specific Membrane Antigen-PET Imaging of Recurrent Prostate Cancer. JAMA Netw Open. 2024 Oct 1;7(10):e2440591. doi: 10.1001/jamanetworkopen.2024.40591. PMID: 39441595; PMCID: PMC11581571.

    The objective was to estimate long-term outcomes of integrating PSMA-PET into the staging pathway for recurrent prostate cancer.


    [Rickey LM]. 241 - BLADDER HEALTH IN WOMEN: POPULATION-BASED ESTIMATES FROM THE US-BASED RISE FOR HEALTH STUDY. Continence (Amsterdam). 10/2024;12:101583. doi: 10.1016/j.cont.2024.101583.

    The goal of this analysis is to describe these distributions among RISE participants. A secondary goal is to describe the distributions of bladder health among women without LUTS, as we hypothesize that sub-optimal bladder health characteristics captured by the BHS/BFI may place women at greater risk of developing LUTS.


    [Rotker K, Honig S]. TRENDS IN POST VASECTOMY SEMEN ANALYSIS (PVSA) UTILIZATION PRE- AND POST-DOBBS V JACKSON: DATA FROM A LIBERAL-LEANING STATE. Fertil Steril. 10/2024;122(4):e375-e376. doi: 10.1016/j.fertnstert.2024.08.158.

    The purpose of our study was to employ post-vasectomy semen analysis (PVSA) as a surrogate for vasectomy rates in Connecticut, a liberal-leaning state, to determine if this overturned statute affected vasectomy behavior.


    Cedars B [Sterling J]. P026 efficacy of endoscopic urethral stricture treatment using lighted catheter: A pilot trial. European urology open science (Online). 10/2024;69:S36-S37. doi: 10.1016/s2666-1683(24)00953-4.

    Red and near-infrared light (NIR) have been shown to promote wound healing and reduce inflammation via positive photobiomodulation in multiple injury models. We aimed to implement these biostimulatory properties using a lighted catheter for urethral stricture disease.


    Hayden C [Honig S, Rotker K]. POSTHUMOUS SPERM RETRIEVAL: SURVEY OF KNOWLEDGE OF INTENSIVE CARE UNIT PROVIDERS. Fertil Steril. 10/2024;122(4):e318. doi: 10.1016/j.fertnstert.2024.07.965.

    The purpose of this study was to evaluate Intensive Care Unit (ICU) providers at our institution to gauge their knowledge of and comfort with counseling regarding posthumous sperm retrieval (PSR).

    ###