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Colorectal

  1. In patients with colorectal peritoneal metastases undergoing cytoreductive surgery, does plasma-based liquid biopsy offer better sensitivity, specificity, and lead time in detecting recurrence compared with standard surveillance modalities?
  2. In patients with colorectal peritoneal metastases, what is the sensitivity and specificity of plasma-based liquid biopsy in evaluating response to systemic therapy?
  3. In patients with colorectal peritoneal metastases undergoing cytoreductive surgery, what is the optimal sequence of systemic therapy?