Inhibition of endo-lysosomal function exacerbates vascular calcification
Cai Y, Wang XL, Flores AM, Lin T, Guzman RJ. Inhibition of endo-lysosomal function exacerbates vascular calcification. Scientific Reports 2018, 8: 3377. PMID: 29467541, PMCID: PMC5821871, DOI: 10.1038/s41598-017-17540-6.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsVascular calcificationAortic rings ex vivoChronic kidney diseaseMedial artery calcificationSmooth muscle cellsLysosomal inhibitor chloroquineCardiovascular morbidityArtery calcificationPathologic responseDiabetes mellitusAortic ringsKidney diseaseMedial calcificationVitamin D3Osteogenic transformationVSMC calcificationLysosomal marker lysosomeProtective roleLysosome inhibitionInhibitor chloroquineMembrane protein 2Ex vivoMuscle cellsCalcification