2009
Regulation of Endothelial Nitric Oxide Synthase (eNOS) in Myocardium Subjected to Cardioplegic Arrest
Fischer U, Klass O, Cox C, Stock U, Antonyan A, Brixius K, Fischer J, Mehlhorn U, Bloch W. Regulation of Endothelial Nitric Oxide Synthase (eNOS) in Myocardium Subjected to Cardioplegic Arrest. The Thoracic And Cardiovascular Surgeon 2009, 57: 379-385. PMID: 19795322, DOI: 10.1055/s-0029-1185873.Peer-Reviewed Original ResearchAnimalsCardiopulmonary BypassEnzyme ActivationFemaleHeart Arrest, InducedHeart VentriclesImmunohistochemistryMaleMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Models, AnimalMyocardial ContractionMyocardiumNitric Oxide Synthase Type IIIPhosphorylationProto-Oncogene Proteins c-aktSerineSwineThreonineTime FactorsVentricular Function, Left
2008
DISTRIBUTION OF NOS ISOFORMS IN A PORCINE ENDOTOXIN SHOCK MODEL
Doursout M, Oguchi T, Fischer U, Liang Y, Chelly B, Hartley C, Chelly J. DISTRIBUTION OF NOS ISOFORMS IN A PORCINE ENDOTOXIN SHOCK MODEL. Shock 2008, 29: 692-702. PMID: 17909454, PMCID: PMC3341620, DOI: 10.1097/shk.0b013e3181598b77.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCardiomyopathiesCoronary CirculationDisease Models, AnimalEnzyme ActivationEnzyme InhibitorsGene Expression Regulation, EnzymologicGuanidinesHemodynamicsHypotensionIsoenzymesLipopolysaccharidesNitric OxideNitric Oxide Synthase Type IINitric Oxide Synthase Type IIIOmega-N-MethylarginineOrgan SpecificityShock, SepticSwineVasoconstrictionVasodilationVasodilator AgentsConceptsCardiac depressionSeptic shockNOS inhibitorIsoform-specific NOS inhibitorsPorcine endotoxin shock modelNonspecific NOS inhibitorRegional hemodynamic parametersEndotoxin shock modelNovel therapeutic agentsDistribution of eNOSMesenteric vasoconstrictionRenal vasoconstrictionVasoconstrictor mediatorsEndogenous vasodilatorBlood pressureMyocardial depressionOrgan dysfunctionLPS infusionVascular toneEndotoxin administrationINOS activityHemodynamic parametersVascular bedHepatic vasodilationConscious pigs
2004
Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery
Fischer U, Tossios P, Huebner A, Geissler H, Bloch W, Mehlhorn U. Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery. Journal Of Thoracic And Cardiovascular Surgery 2004, 128: 103-108. PMID: 15224028, DOI: 10.1016/j.jtcvs.2003.11.034.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAgedApoptosisCardiopulmonary BypassCaspase 3Caspase 7CaspasesCoronary Artery BypassCoronary Artery DiseaseDouble-Blind MethodEnzyme ActivationFemaleFree Radical ScavengersHeart RateHumansMaleMiddle AgedMyocardiumMyocytes, CardiacTreatment OutcomeVascular ResistanceVentricular Function, LeftVentricular PressureConceptsVentricular biopsy samplesN-acetylcysteineCardioplegic arrestBiopsy samplesCoronary artery bypass graft patientsLeft ventricular cardiac myocytesCardiac surgery patientsBypass graft patientsDouble-blind fashionConfidence intervalsCaspase-3Apoptosis inductionVentricular cardiac myocytesOxygen-derived speciesGraft patientsGray unitsSurgery patientsCardiac surgeryCardiopulmonary bypassClinical outcomesActive caspase-3Myocardial ischemiaApoptosis signal cascadePatientsCardiac myocytes