2009
Regulation of Endothelial Nitric Oxide Synthase (eNOS) in Myocardium Subjected to Cardioplegic Arrest
Fischer U, Klass O, Cox C, Stock U, Antonyan A, Brixius K, Fischer J, Mehlhorn U, Bloch W. Regulation of Endothelial Nitric Oxide Synthase (eNOS) in Myocardium Subjected to Cardioplegic Arrest. The Thoracic And Cardiovascular Surgeon 2009, 57: 379-385. PMID: 19795322, DOI: 10.1055/s-0029-1185873.Peer-Reviewed Original ResearchAnimalsCardiopulmonary BypassEnzyme ActivationFemaleHeart Arrest, InducedHeart VentriclesImmunohistochemistryMaleMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Models, AnimalMyocardial ContractionMyocardiumNitric Oxide Synthase Type IIIPhosphorylationProto-Oncogene Proteins c-aktSerineSwineThreonineTime FactorsVentricular Function, Left
2008
DISTRIBUTION OF NOS ISOFORMS IN A PORCINE ENDOTOXIN SHOCK MODEL
Doursout M, Oguchi T, Fischer U, Liang Y, Chelly B, Hartley C, Chelly J. DISTRIBUTION OF NOS ISOFORMS IN A PORCINE ENDOTOXIN SHOCK MODEL. Shock 2008, 29: 692-702. PMID: 17909454, PMCID: PMC3341620, DOI: 10.1097/shk.0b013e3181598b77.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCardiomyopathiesCoronary CirculationDisease Models, AnimalEnzyme ActivationEnzyme InhibitorsGene Expression Regulation, EnzymologicGuanidinesHemodynamicsHypotensionIsoenzymesLipopolysaccharidesNitric OxideNitric Oxide Synthase Type IINitric Oxide Synthase Type IIIOmega-N-MethylarginineOrgan SpecificityShock, SepticSwineVasoconstrictionVasodilationVasodilator AgentsConceptsCardiac depressionSeptic shockNOS inhibitorIsoform-specific NOS inhibitorsPorcine endotoxin shock modelNonspecific NOS inhibitorRegional hemodynamic parametersEndotoxin shock modelNovel therapeutic agentsDistribution of eNOSMesenteric vasoconstrictionRenal vasoconstrictionVasoconstrictor mediatorsEndogenous vasodilatorBlood pressureMyocardial depressionOrgan dysfunctionLPS infusionVascular toneEndotoxin administrationINOS activityHemodynamic parametersVascular bedHepatic vasodilationConscious pigs