Intravenous mesenchymal stem cell therapy for traumatic brain injury.
Harting M, Jimenez F, Xue H, Fischer U, Baumgartner J, Dash P, Cox C. Intravenous mesenchymal stem cell therapy for traumatic brain injury. Journal Of Neurosurgery 2009, 110: 1189-97. PMID: 19301973, PMCID: PMC2889620, DOI: 10.3171/2008.9.jns08158.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain InjuriesCell Culture TechniquesCognitionInfusions, IntravenousLungMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMotor ActivityRatsRats, Sprague-DawleyRecovery of FunctionReflexStaining and LabelingConceptsTraumatic brain injuryMesenchymal stem cell therapyArterial circulationStem cell therapyWeeks postinfusionFunctional recoveryCell therapyPulmonary microvasculatureBrain injuryCortical impact traumatic brain injuryPulmonary first-pass effectImpact traumatic brain injuryIntravenous MSC therapyRecovery of motorCognitive function recoveryFirst-pass effectMeasurements of motorMSC infusionCerebral parenchymaFunction recoveryIntravenous infusionMSC therapyPreclinical promiseFunctional improvementCarotid artery