2005
Resuscitation-Induced Gut Edema and Intestinal Dysfunction
Moore-Olufemi S, Xue H, Attuwaybi B, Fischer U, Harari Y, Oliver D, Weisbrodt N, Allen S, Moore F, Stewart R, Laine G, Cox C. Resuscitation-Induced Gut Edema and Intestinal Dysfunction. Journal Of Trauma And Acute Care Surgery 2005, 58: 264-270. PMID: 15706186, DOI: 10.1097/01.ta.0000133571.64393.d2.Peer-Reviewed Original ResearchConceptsMesenteric venous hypertensionGut edemaIntra-abdominal hypertensionVenous hypertensionIntestinal transitGroup BAltered gut barrier functionIschemia/reperfusion injuryBarrier functionGut barrier functionML/Mucosal injuryMyeloperoxidase activityFluid resuscitationIntestinal dysfunctionMucosal permeabilityReperfusion injurySham surgeryGut motilityGut functionHypertensionGroup AEdemaTissue resistanceInjury measurements
2003
Regional hypothermia reduces mucosal NF-κB and PMN priming via gut lymph during canine mesenteric Ischemia/Reperfusion1,2 1This paper was presented at the annual meeting of the Association for Academic Surgery, November 7–9, 2002, Boston, MA. 2Supported in part by NIGMS grants P50 GM38529-01, KO8 GM000675, and T32 GM08792.
Hassoun H, Fischer U, Attuwaybi B, Moore F, Safi H, Allen S, Cox C. Regional hypothermia reduces mucosal NF-κB and PMN priming via gut lymph during canine mesenteric Ischemia/Reperfusion1,2 1This paper was presented at the annual meeting of the Association for Academic Surgery, November 7–9, 2002, Boston, MA. 2Supported in part by NIGMS grants P50 GM38529-01, KO8 GM000675, and T32 GM08792. Journal Of Surgical Research 2003, 115: 121-126. PMID: 14572782, DOI: 10.1016/s0022-4804(03)00298-1.Peer-Reviewed Original ResearchConceptsTransvascular protein clearancePMN superoxide productionGut lymphIntraischemic hypothermiaNF-kappaB DNAProtein clearancePMN primingFistula modelRegional hypothermiaMesenteric ischemia/reperfusionSuperoxide productionPolymorphonuclear neutrophil (PMN) primingRemote organ injuryPro-inflammatory mediatorsMin of reperfusionEnd of ischemiaIschemia/reperfusionNF-kappaB activationNF-kappaB activityMesenteric ischemiaNeutrophil primingH reperfusionOrgan injuryReperfusion injuryMin reperfusion