2015
En Bloc Resection of Pancoast Tumor with Adjuvant Aortic Endograft and Chemoradiation
Lu T, Fischer U, Marco R, Naoum J, Reardon M, Lumsden A, Blackmon S, Davies M. En Bloc Resection of Pancoast Tumor with Adjuvant Aortic Endograft and Chemoradiation. Methodist DeBakey Cardiovascular Journal 2015, 11: 140-4. PMID: 26306134, PMCID: PMC4547671, DOI: 10.14797/mdcj-11-2-140.Peer-Reviewed Original ResearchMeSH KeywordsAorta, ThoracicBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationCarcinoma, Non-Small-Cell LungChemoradiotherapy, AdjuvantEndovascular ProceduresFemaleHumansLung NeoplasmsMagnetic Resonance ImagingMiddle AgedNeoplasm StagingPancoast SyndromePneumonectomyPolyethylene TerephthalatesProsthesis DesignTreatment OutcomeConceptsBloc resectionAortic endograftsGore TAG thoracic endograftCarotid-subclavian bypassOpen operative managementSensitive anatomic locationEn bloc resectionAdjuvant chemoradiationAortic invasionAortic involvementAortic resectionChemoradiation regimensSubsequent chemoradiationAdjuvant therapyAortic injuryPancoast tumorStage IIIABony invasionSelect patientsAortic ruptureCardiopulmonary bypassSubclavian arteryComplex resectionsUpper lobeHigh morbidity
2007
Radical scavenging for renal protection in cardiac surgery
Fischer U, Mehlhorn U. Radical scavenging for renal protection in cardiac surgery. Clinical Research In Cardiology Supplements 2007, 2: s81-s84. DOI: 10.1007/s11789-006-0042-9.Peer-Reviewed Original ResearchExtracorporeal Circulation activates endothelial Nitric Oxide Synthase (eNOS) in Erythrocytes
Fischer U, Schindler R, Brixius K, Mehlhorn U, Bloch W. Extracorporeal Circulation activates endothelial Nitric Oxide Synthase (eNOS) in Erythrocytes. The FASEB Journal 2007, 21: a1230-a1230. DOI: 10.1096/fasebj.21.6.a1230.Peer-Reviewed Original ResearchRed blood cellsCardiopulmonary bypassExtracorporeal circulationNitric oxide generationRBC-eNOSTime-dependent fashionSevere hypotensionCardiac surgeryPathophysiological hypothesesBlood samplesENOS activationHuman red blood cellsOxide generationBlood cellsENOSBypassDegree of activationHypotensionDependent fashionImportant predictorActivationMorbidityVasodilationHemodialysisPatients
2005
Mild Hypothermia Impairs Left Ventricular Diastolic but Not Systolic Function
Fischer U, Cox C, Laine G, Mehlhorn U, Allen S. Mild Hypothermia Impairs Left Ventricular Diastolic but Not Systolic Function. Journal Of Investigative Surgery 2005, 18: 291-296. PMID: 16319049, DOI: 10.1080/08941930500327047.Peer-Reviewed Original ResearchConceptsPreload recruitable stroke workSystolic functionCardiopulmonary bypassCardiac outputCardioplegic arrestBody temperatureEarly post-CPB periodPost-CPB periodImpact of hypothermiaLeft ventricular functionRecruitable stroke workDP/Ventricular diastolicDiastolic functionCardiac dysfunctionVentricular functionLV diastolicHYPO groupCPB periodMyocardial protectionAnesthetized dogsMild hypothermiaStroke workLV micromanometerBaseline levels
2004
The effect of preoperative antiplatelet therapy in coronary artery surgery: blood transfusion requirements for patients on cardiopulmonary bypass
Hekmat K, Menzel C, Kroener A, Schwinger R, Kampe S, Fischer U, Geissler H, Mehlhorn U. The effect of preoperative antiplatelet therapy in coronary artery surgery: blood transfusion requirements for patients on cardiopulmonary bypass. Current Medical Research And Opinion 2004, 20: 1429-1435. PMID: 15383191, DOI: 10.1185/030079904x2060.Peer-Reviewed Original ResearchConceptsAntiplatelet therapyCardiopulmonary bypassTransfusion requirementsControl patientsHomologous blood requirementsMediastinal tube drainagePreoperative antiplatelet therapyBlood transfusion requirementsCoronary artery bypassCoronary artery surgeryCoronary bypass surgeryFresh frozen plasma unitsAPT groupFrozen plasma unitsIntra-operative dataAPT therapyCON patientsElective CABGArtery bypassArtery surgeryBypass surgeryCommon complicationHospital dischargeTube drainageBlood lossMyocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery
Fischer U, Tossios P, Huebner A, Geissler H, Bloch W, Mehlhorn U. Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery. Journal Of Thoracic And Cardiovascular Surgery 2004, 128: 103-108. PMID: 15224028, DOI: 10.1016/j.jtcvs.2003.11.034.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAgedApoptosisCardiopulmonary BypassCaspase 3Caspase 7CaspasesCoronary Artery BypassCoronary Artery DiseaseDouble-Blind MethodEnzyme ActivationFemaleFree Radical ScavengersHeart RateHumansMaleMiddle AgedMyocardiumMyocytes, CardiacTreatment OutcomeVascular ResistanceVentricular Function, LeftVentricular PressureConceptsVentricular biopsy samplesN-acetylcysteineCardioplegic arrestBiopsy samplesCoronary artery bypass graft patientsLeft ventricular cardiac myocytesCardiac surgery patientsBypass graft patientsDouble-blind fashionConfidence intervalsCaspase-3Apoptosis inductionVentricular cardiac myocytesOxygen-derived speciesGraft patientsGray unitsSurgery patientsCardiac surgeryCardiopulmonary bypassClinical outcomesActive caspase-3Myocardial ischemiaApoptosis signal cascadePatientsCardiac myocytesEffect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest
Klass O, Fischer U, Perez E, Easo J, Bosse M, Fischer J, Tossios P, Mehlhorn U. Effect of the Na+/H+ exchange inhibitor eniporide on cardiac performance and myocardial high energy phosphates in pigs subjected to cardioplegic arrest. The Annals Of Thoracic Surgery 2004, 77: 658-663. PMID: 14759455, DOI: 10.1016/s0003-4975(03)01604-7.Peer-Reviewed Original ResearchMeSH KeywordsAdenine NucleotidesAnimalsCardiopulmonary BypassDose-Response Relationship, DrugEnergy MetabolismGlycogenGuanidinesHeart Arrest, InducedHemodynamicsMyocardial ContractionMyocardial Reperfusion InjuryPremedicationSodium-Hydrogen ExchangersSulfonesSwineVentricular Function, LeftWater-Electrolyte BalanceConceptsIschemia/reperfusionCardiopulmonary bypassCardioplegic arrestCrystalloid cardioplegic arrestCardiac performanceMyocardial adenine nucleotidesPreload recruitable stroke workMyocardial ischemia/reperfusionLeft ventricular isovolumic relaxationCold crystalloid cardioplegic arrestRecruitable stroke workMyocardial high-energy phosphatesHigh-energy phosphate contentHealthy pig heartsVentricular isovolumic relaxationAdenine nucleotidesRelevant pig modelHigh-energy phosphatesCardiac indexStandard hemodynamicsAcute studySystemic infusionStroke workVascular pressuresIsovolumic relaxation
2003
Nitrotyrosine and 8-isoprostane formation indicate free radical-mediated injury in hearts of patients subjected to cardioplegia
Mehlhorn U, Krahwinkel A, Geissler H, LaRosee K, Fischer U, Klass O, Suedkamp M, Hekmat K, Tossios P, Bloch W. Nitrotyrosine and 8-isoprostane formation indicate free radical-mediated injury in hearts of patients subjected to cardioplegia. Journal Of Thoracic And Cardiovascular Surgery 2003, 125: 178-183. PMID: 12539002, DOI: 10.1067/mtc.2003.97.Peer-Reviewed Original ResearchConceptsEnd of bypassCardiopulmonary bypassCyclic guanosine monophosphateMyocardial ischemiaIntermittent cold blood cardioplegiaConstitutive nitric oxide synthaseNitric oxide synthase activityNitric oxide synthase activationCyclic guanosine monophosphate contentOxygen-derived free radicalsCardiac myocytesCoronary endothelial injuryCoronary artery operationsFree radical-mediated lipid peroxidationCold blood cardioplegiaFree radical-mediated injuryGuanosine monophosphateHearts of patientsOxide synthase activityNitric oxide synthaseRadical-mediated lipid peroxidationVentricular biopsy specimensRadical-mediated injuryNitric oxide releaseBlood cardioplegia
2002
Impact of cardiopulmonary bypass management on postcardiac surgery renal function
Fischer U, Weissenberger W, Warters R, Geissler H, Allen S, Mehlhorn U. Impact of cardiopulmonary bypass management on postcardiac surgery renal function. Perfusion 2002, 17: 401-406. PMID: 12470028, DOI: 10.1191/0267659102pf610oa.Peer-Reviewed Original ResearchConceptsPostoperative acute renal failureAcute renal failureNormal preoperative renal functionPreoperative renal functionPostoperative renal dysfunctionPostoperative renal functionRenal functionCardiopulmonary bypassCPB durationRenal dysfunctionCPB flowArterial pressurePerfusion pressurePerioperative low cardiac output syndromeCPB managementLow cardiac output syndromeNormal postoperative renal functionLonger CPB durationMean arterial pressureCardiac surgical proceduresGroup of patientsCardiopulmonary bypass managementFuture clinical studiesARF preventionOutput syndrome