2004
Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery
Fischer U, Tossios P, Huebner A, Geissler H, Bloch W, Mehlhorn U. Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery. Journal Of Thoracic And Cardiovascular Surgery 2004, 128: 103-108. PMID: 15224028, DOI: 10.1016/j.jtcvs.2003.11.034.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAgedApoptosisCardiopulmonary BypassCaspase 3Caspase 7CaspasesCoronary Artery BypassCoronary Artery DiseaseDouble-Blind MethodEnzyme ActivationFemaleFree Radical ScavengersHeart RateHumansMaleMiddle AgedMyocardiumMyocytes, CardiacTreatment OutcomeVascular ResistanceVentricular Function, LeftVentricular PressureConceptsVentricular biopsy samplesN-acetylcysteineCardioplegic arrestBiopsy samplesCoronary artery bypass graft patientsLeft ventricular cardiac myocytesCardiac surgery patientsBypass graft patientsDouble-blind fashionConfidence intervalsCaspase-3Apoptosis inductionVentricular cardiac myocytesOxygen-derived speciesGraft patientsGray unitsSurgery patientsCardiac surgeryCardiopulmonary bypassClinical outcomesActive caspase-3Myocardial ischemiaApoptosis signal cascadePatientsCardiac myocytes
2003
Nitrotyrosine and 8-isoprostane formation indicate free radical-mediated injury in hearts of patients subjected to cardioplegia
Mehlhorn U, Krahwinkel A, Geissler H, LaRosee K, Fischer U, Klass O, Suedkamp M, Hekmat K, Tossios P, Bloch W. Nitrotyrosine and 8-isoprostane formation indicate free radical-mediated injury in hearts of patients subjected to cardioplegia. Journal Of Thoracic And Cardiovascular Surgery 2003, 125: 178-183. PMID: 12539002, DOI: 10.1067/mtc.2003.97.Peer-Reviewed Original ResearchConceptsEnd of bypassCardiopulmonary bypassCyclic guanosine monophosphateMyocardial ischemiaIntermittent cold blood cardioplegiaConstitutive nitric oxide synthaseNitric oxide synthase activityNitric oxide synthase activationCyclic guanosine monophosphate contentOxygen-derived free radicalsCardiac myocytesCoronary endothelial injuryCoronary artery operationsFree radical-mediated lipid peroxidationCold blood cardioplegiaFree radical-mediated injuryGuanosine monophosphateHearts of patientsOxide synthase activityNitric oxide synthaseRadical-mediated lipid peroxidationVentricular biopsy specimensRadical-mediated injuryNitric oxide releaseBlood cardioplegia