2016
Proposing prognostic thresholds for lymph node yield in clinically lymph node‐negative and lymph node‐positive cancers of the oral cavity
Kuo P, Mehra S, Sosa JA, Roman SA, Husain ZA, Burtness BA, Tate JP, Yarbrough WG, Judson BL. Proposing prognostic thresholds for lymph node yield in clinically lymph node‐negative and lymph node‐positive cancers of the oral cavity. Cancer 2016, 122: 3624-3631. PMID: 27479645, DOI: 10.1002/cncr.30227.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseOral cavity cancerMortality hazard ratioLymph nodesHazard ratioNeck dissectionLymph node-negative cancersLymph node-positive cancersNode-positive cancersNode-positive cohortPositive lymph nodesTherapeutic neck dissectionEnd Results (SEER) databaseLymph node yieldHigh-volume centersExtensive neck dissectionMultiple cancer sitesNode-negative cancersOverall survivalHigher lymphPrognostic factorsTreatment guidelinesNode yieldResults databaseSurgical management
2014
Intrathyroidal Tumors Presenting with Extranodal Extension: What Are We Missing?
Clain JB, Mehra S, Scherl S, Dos Reis LL, Turk A, Wenig BM, Dewey EH, Urken ML. Intrathyroidal Tumors Presenting with Extranodal Extension: What Are We Missing? Endocrine Pathology 2014, 25: 385-389. PMID: 25325929, DOI: 10.1007/s12022-014-9340-9.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesHistocytochemistryHumansLymphatic MetastasisNeoplasm InvasivenessPredictive Value of TestsRetrospective StudiesThyroid NeoplasmsConceptsExtranodal extensionHistologic featuresIntrathyroidal tumorsLymphovascular invasionPerineural invasionLymphocytic thyroiditisLymph nodesPrimary tumorPsammoma bodiesNode-positive patientsPositive lymph nodesSubset of patientsFischer's exact testGroup A/BMann-Whitney testIntrathyroidal diseaseAggressive biologyPathologic featuresPoor prognosisTumor sizeThyroid cancerAggressive phenotypeExact testTumorsPatientsThe Effect of Surgeon Experience on the Detection of Metastatic Lymph Nodes in the Central Compartment and the Pathologic Features of Clinically Unapparent Metastatic Lymph Nodes: What Are We Missing When We Don't Perform a Prophylactic Dissection of Central Compartment Lymph Nodes in Papillary Thyroid Cancer?
Scherl S, Mehra S, Clain J, Dos Reis LL, Persky M, Turk A, Wenig B, Husaini H, Urken ML. The Effect of Surgeon Experience on the Detection of Metastatic Lymph Nodes in the Central Compartment and the Pathologic Features of Clinically Unapparent Metastatic Lymph Nodes: What Are We Missing When We Don't Perform a Prophylactic Dissection of Central Compartment Lymph Nodes in Papillary Thyroid Cancer? Thyroid 2014, 24: 1282-1288. PMID: 24787362, DOI: 10.1089/thy.2013.0600.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCarcinomaCarcinoma, PapillaryFalse Negative ReactionsFalse Positive ReactionsFemaleHashimoto DiseaseHumansIntraoperative PeriodLymph NodesLymphatic MetastasisMaleMiddle AgedNeck DissectionProfessional CompetenceRiskSensitivity and SpecificitySurgeonsThyroid Cancer, PapillaryThyroid NeoplasmsThyroidectomyYoung AdultConceptsProphylactic central neck dissectionPapillary thyroid cancerMetastatic lymph nodesExtranodal extensionLymph nodesOccult metastasesPositive nodesSurgeon experienceOccult nodesPathologic featuresThyroid cancerPresence of ENECentral compartment lymph nodesAdverse histologic featuresMultiple positive nodesPositive central nodesSenior surgeon's assessmentCentral neck dissectionFalse-negative casesGroup of surgeonsEvident nodesPreoperative evidenceProphylactic dissectionNeck dissectionRisk stratificationExtrathyroidal Extension Predicts Extranodal Extension in Patients with Positive Lymph Nodes: An Important Association That May Affect Clinical Management
Clain JB, Scherl S, Dos Reis L, Turk A, Wenig BM, Mehra S, Karle WE, Urken ML. Extrathyroidal Extension Predicts Extranodal Extension in Patients with Positive Lymph Nodes: An Important Association That May Affect Clinical Management. Thyroid 2014, 24: 951-957. PMID: 24443878, DOI: 10.1089/thy.2013.0557.Peer-Reviewed Original ResearchMeSH KeywordsHumansLymphatic MetastasisPrognosisRetrospective StudiesThyroid NeoplasmsThyroidectomyThyroxineTriiodothyronineConceptsExtranodal extensionLymph nodesPrimary tumorPresence of ENEAmerican Pathologists (CAP) protocolNode-positive patientsPositive lymph nodesRecurrent lymph nodesUpstaging of patientsMajority of patientsAggressive disease biologyLong-term survivalPresence of extensionCompletion thyroidectomyPositive nodesNodal metastasisRetrospective reviewHistologic featuresClinical managementDisease aggressivenessThyroid cancerT4 casesThyroid carcinomaHigh incidencePatients