2020
Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype
Cai Y, Rattray NJW, Zhang Q, Mironova V, Santos-Neto A, Hsu KS, Rattray Z, Cross JR, Zhang Y, Paty PB, Khan SA, Johnson CH. Sex Differences in Colon Cancer Metabolism Reveal A Novel Subphenotype. Scientific Reports 2020, 10: 4905. PMID: 32184446, PMCID: PMC7078199, DOI: 10.1038/s41598-020-61851-0.Peer-Reviewed Original ResearchConceptsRight-sided colon cancerColorectal cancerCRC patientsColon cancer metabolismPoor clinical outcomePatient colon tumorsAsparagine synthetase expressionNovel subphenotypesClinical outcomesAmino acid uptakePoor survivalLower incidenceAnatomic locationHigh incidenceTherapeutic targetColon cancerCancer Genomic AtlasClinical importanceColon tumorsTumor progressionAberrant metabolismNormal tissuesPatientsSubphenotypesAcid uptake
2010
Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer
Cheng Y, Idrees K, Shattock R, Khan SA, Zeng Z, Brennan CW, Paty P, Barany F. Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer. International Journal Of Cancer 2010, 127: 568-577. PMID: 19957330, PMCID: PMC3270092, DOI: 10.1002/ijc.25086.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor 2IGF2 LOIColorectal cancerLoss of imprintingPrimary colorectal cancerIGF2 expressionNormal colorectal tissuesPrimary CRC tumorsSignificant correlationGrowth factor 2CRC tumorigenesisCRC tumorsIGF2 levelsColorectal tissuesIGF2 overexpressionH19 methylationHuman malignanciesMicrosatellite instabilityExpression correlatesNormal tissuesH19 hypomethylationCancerCommon eventAberrant gene expressionFactor 2