2024
Cell surface RNAs control neutrophil recruitment
Zhang N, Tang W, Torres L, Wang X, Ajaj Y, Zhu L, Luan Y, Zhou H, Wang Y, Zhang D, Kurbatov V, Khan S, Kumar P, Hidalgo A, Wu D, Lu J. Cell surface RNAs control neutrophil recruitment. Cell 2024, 187: 846-860.e17. PMID: 38262409, PMCID: PMC10922858, DOI: 10.1016/j.cell.2023.12.033.Peer-Reviewed Original ResearchConceptsCell surfaceMammalian homologOuter cell surfaceRNA transportGlycan modificationsMammalian cellsSID-1Cellular functionsRecruitment to inflammatory sitesGlycoRNARNAMurine neutrophilsFunctional significanceNeutrophil recruitmentNeutrophil recruitment to inflammatory sitesBiological importanceCellsNeutrophil adhesionReduced neutrophil adhesionHomologyGlycansGenesInflammatory sitesRecruitmentEndothelial cells
2021
Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma
Hasan NM, Sharma A, Ruzgar NM, Deshpande H, Olino K, Khan S, Ahuja N. Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma. Oncotarget 2021, 12: 1566-1579. PMID: 34381562, PMCID: PMC8351604, DOI: 10.18632/oncotarget.28032.Peer-Reviewed Original ResearchDNA methylationGene expressionSubtype-specific gene expressionDifferential DNA methylationGene expression patternsPromoter CpG islandsRNA-seq dataEpigenetic regulationEpigenetic profilingEpigenetic signaturesCpG islandsEpigenetic alterationsExpression patternsGenesMethylationUnsupervised hierarchical clusteringPotential therapeutic targetMolecular landscapeIntegrated analysisMain clustersPotential targetTherapeutic targetExpressionSubtype-specific differencesMultiple aspects
2019
APC mutational patterns in gastric adenocarcinoma are enriched for missense variants with associated decreased survival
Rubinstein JC, Khan SA, Christison‐Lagay E, Cha C. APC mutational patterns in gastric adenocarcinoma are enriched for missense variants with associated decreased survival. Genes Chromosomes And Cancer 2019, 59: 64-68. PMID: 31353684, DOI: 10.1002/gcc.22792.Peer-Reviewed Original ResearchGenomic Data CommonsSingle nucleotide variantsAPC mutationsMutational patternsMissense mutationsSpecific APC mutationsMissense variantsRecurrent somatic eventsProtein dysfunctionAdenomatous polyposis coli (APC) mutationsNucleotide variantsSpecific mutational patternsSomatic eventsMutationsNumerous tumor typesResultant clinical manifestationsDifferent mutationsFuture risk stratification strategiesFamilial adenomatous polyposisData CommonsVariantsColon adenocarcinomaColon cancerGenesColon tumors