Temporal Regulation of venous Extracellular Matrix Components during Arteriovenous Fistula Maturation
Hall MR, Yamamoto K, Protack CD, Tsuneki M, Kuwahara G, Assi R, Brownson KE, Bai H, Madri JA, Dardik A. Temporal Regulation of venous Extracellular Matrix Components during Arteriovenous Fistula Maturation. The Journal Of Vascular Access 2014, 16: 93-106. PMID: 25262757, PMCID: PMC4405006, DOI: 10.5301/jva.5000290.Peer-Reviewed Original ResearchConceptsExtracellular matrix componentsTemporal regulationECM componentsStructural proteinsMatrix componentsGene microarray analysisMatrix metalloproteinasesRegulatory proteinsMicroarray analysisNon-collagenous proteinsDistinct temporal patternsECM degradationTemporal patternsProteinProtein expressionElastin expressionExpressionMaturationOsteopontin expressionProtease inhibitorsHuman AVF maturationRegulationTissue inhibitorDays of maturationMetalloproteinase-1Vein graft adaptation and fistula maturation in the arterial environment
Lu DY, Chen EY, Wong DJ, Yamamoto K, Protack CD, Williams WT, Assi R, Hall MR, Sadaghianloo N, Dardik A. Vein graft adaptation and fistula maturation in the arterial environment. Journal Of Surgical Research 2014, 188: 162-173. PMID: 24582063, PMCID: PMC3972303, DOI: 10.1016/j.jss.2014.01.042.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaVein graftsVein graft adaptationVenous adaptationGraft adaptationArterial environmentCommon surgical procedureAVF maturationDifferent hemodynamic conditionsFistula maturationVenous dilationUnderlying molecular mechanismsIntimal thickeningSurgical proceduresWall thickeningHemodynamic conditions