2023
Genetic Overlap of Spontaneous Dissection of Either the Thoracic Aorta or the Coronary Arteries
Jeoffrey S, Kalyanasundaram A, Zafar M, Ziganshin B, Elefteriades J. Genetic Overlap of Spontaneous Dissection of Either the Thoracic Aorta or the Coronary Arteries. The American Journal Of Cardiology 2023, 205: 69-74. PMID: 37591066, DOI: 10.1016/j.amjcard.2023.07.046.Peer-Reviewed Original ResearchMeSH KeywordsAorta, ThoracicAortic DissectionCoronary VesselsGenome-Wide Association StudyHumansProspective StudiesRetrospective StudiesConceptsCorresponding molecular pathwaysSpontaneous coronary artery dissectionGenetic overlapMolecular pathwaysGenome-wide association studiesGenetic commonalityGenetic variantsThoracic aortic dissectionIndependent genesGenetic pathwaysSmooth muscle cell functionGenetic methodsAortic dissectionMuscle cell functionAssociation studiesGenetic studiesSudden deathConnective tissue genesGenesTGFβ pathwayCausative genesCoronary artery dissectionTissue genesEarly-onset myocardial infarctionBiologic processesExtended law of laplace for measurement of the cloverleaf anatomy of the aortic root
Ban E, Kalogerakos P, Khosravi R, Ziganshin B, Ellauzi H, Ramachandra A, Zafar M, Humphrey J, Elefteriades J. Extended law of laplace for measurement of the cloverleaf anatomy of the aortic root. The International Journal Of Cardiovascular Imaging 2023, 39: 1345-1356. PMID: 37046157, PMCID: PMC10250276, DOI: 10.1007/s10554-023-02847-5.Peer-Reviewed Original ResearchMeSH KeywordsAortaAorta, ThoracicAortic ValveBicuspid Aortic Valve DiseaseBlood PressureHumansPredictive Value of TestsConceptsAortic root
2022
Bovine Aortic Arch: A Result of Chance or Mandate of Inheritance?
Shang M, Vinholo TF, Buntin J, Zafar MA, Ziganshin BA, Elefteriades JA. Bovine Aortic Arch: A Result of Chance or Mandate of Inheritance? The American Journal Of Cardiology 2022, 172: 115-120. PMID: 35321803, PMCID: PMC9978865, DOI: 10.1016/j.amjcard.2022.02.030.Peer-Reviewed Original ResearchMeSH KeywordsAneurysmAorta, ThoracicAortic Aneurysm, ThoracicFemaleHumansIncidenceLikelihood FunctionsMaleRetrospective StudiesConceptsBovine archThoracic aortic aneurysmAortic aneurysmThoracic aortic aneurysm diseaseAortic arch configurationAortic aneurysm diseaseSecond-degree relativesInstitutional databaseAneurysm diseaseChest imagingPatientsAneurysmsAvailable scansGenetic mutationsArch resultsArchArch configurationFamily membersSample populationProbandsScansMagnetic resonanceResult of chancePrevious studiesChest
2021
Nationwide collaboration produces valuable data regarding arch and descending aorta
Elefteriades JA, Zafar MA, Ziganshin BA. Nationwide collaboration produces valuable data regarding arch and descending aorta. European Heart Journal 2021, 43: 2370-2372. PMID: 34904151, DOI: 10.1093/eurheartj/ehab854.Peer-Reviewed Original ResearchRoot Dilatation Is More Malignant Than Ascending Aortic Dilation
Kalogerakos PD, Zafar MA, Li Y, Mukherjee SK, Ziganshin BA, Rizzo JA, Elefteriades JA. Root Dilatation Is More Malignant Than Ascending Aortic Dilation. Journal Of The American Heart Association 2021, 10: e020645. PMID: 34238012, PMCID: PMC8483477, DOI: 10.1161/jaha.120.020645.Peer-Reviewed Original ResearchConceptsMid-ascending aortaAortic rootAdverse eventsRoot dilatationNatural historyAcute aortic dissectionLong-term complicationsAortic root dilatationSignificant higher riskThoracic aortic aneurysmSerious risk factorAortic interventionAortic dilatationAortic dilationAortic dissectionAortic aneurysmInternational registryRisk factorsAortic segmentsGuideline criteriaHigh riskExpert centersAortaShort statureResult diametersInterstage mortality in two‐stage elephant trunk surgery
Saeyeldin A, Gryaznov AA, Zafar MA, Wu J, Mukherjee S, Vallabhajosyula P, Ziganshin BA, Elefteriades JA. Interstage mortality in two‐stage elephant trunk surgery. Journal Of Cardiac Surgery 2021, 36: 1882-1891. PMID: 33634489, DOI: 10.1111/jocs.15441.Peer-Reviewed Original ResearchConceptsExtensive thoracic aortic aneurysmThoracic aortic aneurysmInterstage intervalStage IIET procedureStage II procedureHospital mortalityInterstage mortalityMega aortaTrunk surgeryAortic ruptureOverall mortalitySingle surgeonAortic diseasePatient groupAortic aneurysmPatientsStage IMortalityCumulative mortalityI procedureInterval periodRupturePrior studiesSafety
2020
Increased Virulence of Descending Thoracic and Thoracoabdominal Aortic Aneurysms in Women
Chen JF, Zafar MA, Wu J, Li Y, Rizzo JA, Papanikolaou D, Kalogerakos P, Abdelbaky M, Ellauzi H, Rohde S, Vinholo TF, Charilaou P, Buntin J, Mukherjee SK, Ziganshin BA, Elefteriades JA. Increased Virulence of Descending Thoracic and Thoracoabdominal Aortic Aneurysms in Women. The Annals Of Thoracic Surgery 2020, 112: 45-52. PMID: 33075319, DOI: 10.1016/j.athoracsur.2020.08.026.Peer-Reviewed Original ResearchConceptsThoracoabdominal aortic aneurysmsAortic deathFatal complicationAortic sizeAortic aneurysmFaster aneurysm growthMean aortic diameterComplication rateComposite endpointAortic diameterSurgical interventionCurrent guidelinesAneurysm sizeSex considerationsNatural historyAneurysm growthThoracicWomenDissectionYearly rateComplicationsDeathAneurysmsHigh rateSex differences
2019
Natural history of descending thoracic and thoracoabdominal aortic aneurysms
Zafar MA, Chen JF, Wu J, Li Y, Papanikolaou D, Abdelbaky M, Vinholo T, Rizzo JA, Ziganshin BA, Mukherjee SK, Elefteriades JA, Investigators Y, Charilaou P, Saeyeldin A, Imran M, Gryaznov A, Tanweer M, Buntin J, Peterss S. Natural history of descending thoracic and thoracoabdominal aortic aneurysms. Journal Of Thoracic And Cardiovascular Surgery 2019, 161: 498-511.e1. PMID: 31982126, DOI: 10.1016/j.jtcvs.2019.10.125.Peer-Reviewed Original Research
2018
Commentary: Surprisingly good results from a complex, lengthy aortic arch technique
Elefteriades JA, Zafar MA, Papanikolaou D, Ziganshin BA. Commentary: Surprisingly good results from a complex, lengthy aortic arch technique. Journal Of Thoracic And Cardiovascular Surgery 2018, 157: 1379-1380. PMID: 30558875, DOI: 10.1016/j.jtcvs.2018.10.143.Peer-Reviewed Original Research
2017
Thoracic aortic aneurysm: unlocking the “silent killer” secrets
Saeyeldin AA, Velasquez CA, Mahmood SUB, Brownstein AJ, Zafar MA, Ziganshin BA, Elefteriades JA. Thoracic aortic aneurysm: unlocking the “silent killer” secrets. General Thoracic And Cardiovascular Surgery 2017, 67: 1-11. PMID: 29204794, DOI: 10.1007/s11748-017-0874-x.Peer-Reviewed Original ResearchMeSH KeywordsAorta, ThoracicAortic Aneurysm, ThoracicAortic DissectionDiagnostic ImagingDisease ManagementHumansConceptsAortic aneurysmAngiotensin receptor blockersFamilial patternBicuspid aortic valveAbdominal aortic aneurysmRisk of ruptureDifferent embryologic originsReceptor blockersBeta blockersType of repairThoracic aneurysmInflammatory disordersFemale sexSerum biomarkersAortic valveWorse outcomesEmbryologic originMedical treatmentEnzyme inhibitorsAneurysmsSilent killerIntracranial aneurysmsNatural historyOnly reliable methodPattern of inheritance