2011
Myogenic Akt signaling attenuates muscular degeneration, promotes myofiber regeneration and improves muscle function in dystrophin-deficient mdx mice
Kim M, Kay D, Rudra R, Chen B, Hsu N, Izumiya Y, Martinez L, Spencer M, Walsh K, Grinnell A, Crosbie R. Myogenic Akt signaling attenuates muscular degeneration, promotes myofiber regeneration and improves muscle function in dystrophin-deficient mdx mice. Human Molecular Genetics 2011, 20: 1324-1338. PMID: 21245083, PMCID: PMC3049356, DOI: 10.1093/hmg/ddr015.Peer-Reviewed Original ResearchConceptsMdx miceMyofiber regenerationMuscular dystrophyTreatment of mdx miceDystrophin-deficient mdx miceMuscle functionEndogenous compensatory mechanismsExtensor digitorum longus muscleChildhood muscular dystrophyWild-type musclesDuchenne muscular dystrophyResponse relative to controlsGrip strength testImprove muscle functionAkt signaling pathwayDystrophin-glycoprotein complexDystrophin deficiencyOverexpression of AktExtrasynaptic sarcolemmaMuscle wastingHistopathological measurementsDystrophin geneMdxRelative to controlsMuscle degeneration
2008
Myogenic Akt signaling upregulates the utrophin–glycoprotein complex and promotes sarcolemma stability in muscular dystrophy
Peter A, Ko C, Kim M, Hsu N, Ouchi N, Rhie S, Izumiya Y, Zeng L, Walsh K, Crosbie R. Myogenic Akt signaling upregulates the utrophin–glycoprotein complex and promotes sarcolemma stability in muscular dystrophy. Human Molecular Genetics 2008, 18: 318-327. PMID: 18986978, PMCID: PMC2638781, DOI: 10.1093/hmg/ddn358.Peer-Reviewed Original ResearchConceptsMuscle wastingMuscular dystrophyAkt signalingExpression of utrophinProgressive muscle wastingDuchenne muscular dystrophyModulation of AktFunction of dystrophinSarcolemma stabilityPhysiological compensatory mechanismsDystrophin mutationsMouse modelSarcolemma damageDisease outcomeIncreased AktSarcolemma membraneDystrophyCompensatory mechanismsSignaling pathwayDystrophinSarcolemmaUtrophin-glycoprotein complexAkt