Myogenic Akt signaling upregulates the utrophin–glycoprotein complex and promotes sarcolemma stability in muscular dystrophy
Peter A, Ko C, Kim M, Hsu N, Ouchi N, Rhie S, Izumiya Y, Zeng L, Walsh K, Crosbie R. Myogenic Akt signaling upregulates the utrophin–glycoprotein complex and promotes sarcolemma stability in muscular dystrophy. Human Molecular Genetics 2008, 18: 318-327. PMID: 18986978, PMCID: PMC2638781, DOI: 10.1093/hmg/ddn358.Peer-Reviewed Original ResearchConceptsMuscle wastingMuscular dystrophyAkt signalingExpression of utrophinProgressive muscle wastingDuchenne muscular dystrophyModulation of AktFunction of dystrophinSarcolemma stabilityPhysiological compensatory mechanismsDystrophin mutationsMouse modelSarcolemma damageDisease outcomeIncreased AktSarcolemma membraneDystrophyCompensatory mechanismsSignaling pathwayDystrophinSarcolemmaUtrophin-glycoprotein complexAkt