The ATP-Binding Cassette Transporter BCRP1/ABCG2 Plays a Pivotal Role in Cardiac Repair After Myocardial Infarction Via Modulation of Microvascular Endothelial Cell Survival and Function
Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Sahara M, Tanaka K, Koibuchi N, Ito S, Kusuhara H, Sugiyama Y, Hirata Y, Nagai R, Sata M. The ATP-Binding Cassette Transporter BCRP1/ABCG2 Plays a Pivotal Role in Cardiac Repair After Myocardial Infarction Via Modulation of Microvascular Endothelial Cell Survival and Function. Arteriosclerosis Thrombosis And Vascular Biology 2010, 30: 2128-2135. PMID: 20829509, DOI: 10.1161/atvbaha.110.211755.Peer-Reviewed Original ResearchConceptsBreast cancer resistance protein 1BCRP1/ABCG2Myocardial infarctionWT miceCardiac repairEndothelial cellsEndothelial cell survivalAbcg2 knockout micePeri-infarction areaMember 2 expressionTissue defense mechanismsMicrovascular endothelial cellsCell survivalResistance protein 1Cardiac ruptureIntracellular protoporphyrin IXVentricular remodelingKO micePivotal roleHistological assessmentKnockout miceSurvival rateABCG2 inhibitionMiceOxidative stress