2015
Diverse contribution of bone marrow-derived late-outgrowth endothelial progenitor cells to vascular repair under pulmonary arterial hypertension and arterial neointimal formation
Ikutomi M, Sahara M, Nakajima T, Minami Y, Morita T, Hirata Y, Komuro I, Nakamura F, Sata M. Diverse contribution of bone marrow-derived late-outgrowth endothelial progenitor cells to vascular repair under pulmonary arterial hypertension and arterial neointimal formation. Journal Of Molecular And Cellular Cardiology 2015, 86: 121-135. PMID: 26231083, DOI: 10.1016/j.yjmcc.2015.07.019.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionEndothelial progenitor cellsLate outgrowth endothelial progenitor cellsEarly endothelial progenitor cellsFemoral arteryVascular repairEPC subpopulationsArterial hypertensionArterial neointimal formationProgenitor cellsBM mononuclear cellsNeointimal lesion formationFisher 344 ratsEPC treatmentEnhanced proliferation potentialPulmonary arteriolesPulmonary arteryPulmonary vasculatureEndovascular injuryMononuclear cellsVascular diseaseSystemic arteriesTherapeutic effectNeointimal formationInflammatory genes
2007
Diverse Contribution of Bone Marrow–Derived Cells to Vascular Remodeling Associated With Pulmonary Arterial Hypertension and Arterial Neointimal Formation
Sahara M, Sata M, Morita T, Nakamura K, Hirata Y, Nagai R. Diverse Contribution of Bone Marrow–Derived Cells to Vascular Remodeling Associated With Pulmonary Arterial Hypertension and Arterial Neointimal Formation. Circulation 2007, 115: 509-517. PMID: 17242277, DOI: 10.1161/circulationaha.106.655837.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedArteriolesBone Marrow CellsBone Marrow TransplantationCapillariesCell DifferentiationDisease Models, AnimalFemoral ArteryGreen Fluorescent ProteinsHypertension, PulmonaryMaleMonocrotalinePneumonectomyPulmonary ArteryPulmonary EmbolismRatsRats, Sprague-DawleyThrombosisTunica IntimaVentricular Dysfunction, RightConceptsPulmonary arterial hypertensionArterial neointimal formationBM-derived cellsPulmonary arterial remodelingArterial hypertensionPulmonary arteriolesProtein-positive cellsSmooth muscle cellsGreen fluorescent protein-positive cellsArterial remodelingFemoral arteryBM cellsNeointimal formationBone marrowMonocrotaline-induced pulmonary arterial hypertensionRight ventricular systolic pressureMuscle cellsVascular Remodeling AssociatedVentricular systolic pressureGreen fluorescent protein (GFP) transgenic ratsSmooth muscle-like cellsSprague-Dawley ratsWire-injured femoral arteriesMuscle-like cellsPulmonary hypertension