2002
Differences in expression, actions and cocaine regulation of two isoforms for the brain transcriptional regulator NAC1
Korutla L, Wang P, Lewis D, Neustadter J, Stromberg M, Mackler S. Differences in expression, actions and cocaine regulation of two isoforms for the brain transcriptional regulator NAC1. Neuroscience 2002, 110: 421-429. PMID: 11906783, DOI: 10.1016/s0306-4522(01)00518-8.Peer-Reviewed Original ResearchConceptsBTB/POZ proteinPOZ proteinShort isoformDNA binding domainsPost-transcriptional processingSemi-quantitative reverse transcription-polymerase chain reaction analysisPeripheral tissuesRat brainTranscriptional repressionSubnuclear localizationTranscription-polymerase chain reaction analysisBinding domainsReverse transcription-polymerase chain reaction analysisReporter systemCell cycleCocaine-induced locomotionRat nucleus accumbensWestern blot analysisTranscriptionAmino acidsIsoformsProteinChain reaction analysisBlot analysisNeuronal function
2000
NAC-1 Is a Brain POZ/BTB Protein That Can Prevent Cocaine-Induced Sensitization in the Rat
Mackler S, Korutla L, Cha X, Koebbe M, Fournier K, Bowers M, Kalivas P. NAC-1 Is a Brain POZ/BTB Protein That Can Prevent Cocaine-Induced Sensitization in the Rat. Journal Of Neuroscience 2000, 20: 6210-6217. PMID: 10934270, PMCID: PMC6772573, DOI: 10.1523/jneurosci.20-16-06210.2000.Peer-Reviewed Original ResearchConceptsPOZ/BTB proteinBTB proteinsTranscriptional regulatorsNAC-1POZ/BTB domainZinc finger regionTwo-hybrid studiesDNA-binding proteinsBTB domainTranscription factorsGene transcriptionFinger regionReporter geneProteinNuclei of neuronsMammalian brainTranscriptionBehavioral sensitizationPox virusRegulatorCell culturesAdministration of cocaineRat nucleus accumbensExpressionLong-term neuroadaptationsActivation of surfactant protein‐B transcription: Signaling through the SP‐A receptor utilizing the PI3 kinase pathway
Strayer D, Korutla L. Activation of surfactant protein‐B transcription: Signaling through the SP‐A receptor utilizing the PI3 kinase pathway. Journal Of Cellular Physiology 2000, 184: 229-238. PMID: 10867648, DOI: 10.1002/1097-4652(200008)184:2<229::aid-jcp11>3.0.co;2-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedDNA-Binding ProteinsFemaleGlycoproteinsHepatocyte Nuclear Factor 3-alphaLungNuclear ProteinsPhosphatidylinositol 3-KinasesPromoter Regions, GeneticProtein IsoformsProteolipidsPulmonary Surfactant-Associated Protein APulmonary Surfactant-Associated ProteinsPulmonary SurfactantsRatsReceptors, Cell SurfaceThyroid Nuclear Factor 1Transcription FactorsTranscription, GeneticConceptsSP-B promoterSP-B transcriptionPI3-kinaseHNF-3Consensus recognition elementSurfactant proteinsPI3-kinase pathwaySP-A receptorGel shift analysisCell transcriptional activityKinase localizationCellular functionsInteraction of SPTranscription factorsCell biologyNuclear localizationPlasma membraneKinase pathwayTranscriptional activityTranscriptionProteinSpCognate receptorsPromoterType II cells
1999
SP‐A as a cytokine: Surfactant protein‐A–regulated transcription of surfactant proteins and other genes
Korutla L, Strayer D. SP‐A as a cytokine: Surfactant protein‐A–regulated transcription of surfactant proteins and other genes. Journal Of Cellular Physiology 1999, 178: 379-386. PMID: 9989784, DOI: 10.1002/(sici)1097-4652(199903)178:3<379::aid-jcp12>3.0.co;2-c.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCarrier ProteinsCells, CulturedFemaleGene Expression RegulationGenes, fosGenes, junMacrophages, PeritonealProteolipidsPulmonary AlveoliPulmonary Surfactant-Associated Protein APulmonary Surfactant-Associated ProteinsPulmonary SurfactantsRatsRats, Sprague-DawleyRNA, MessengerTranscription, GeneticConceptsType II cellsSurfactant secretionProtein gene transcriptionSurfactant proteinsSurfactant gene expressionOverall transcript levelsC-fos transcriptionSP-A receptorII cellsSP-C mRNA levelsHost antimicrobial defenseSurfactant proteins SPMRNA levelsTranscript stabilityGene transcriptionSP-A effectsTranscript levelsGene expressionTranscriptionC-JunAlveolar type II cellsNew transcriptionSurfactant-associated proteinsSpProtein