2021
Altered transcriptome and disease-related phenotype emerge only after fibroblasts harvested from patients with age-related macular degeneration are differentiated into retinal pigment epithelium
Cai H, Gong J, Team N, Noggle S, Paull D, Rizzolo LJ, Del Priore LV, Fields MA. Altered transcriptome and disease-related phenotype emerge only after fibroblasts harvested from patients with age-related macular degeneration are differentiated into retinal pigment epithelium. Experimental Eye Research 2021, 207: 108576. PMID: 33895162, DOI: 10.1016/j.exer.2021.108576.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationRetinal pigment epitheliumMacular degenerationPigment epitheliumInduced pluripotent stem cellsEtiology of AMDMitochondrial dysfunctionAge-matched controlsNovel therapeutic targetTranscriptome of fibroblastsAMD patientsNormal donorsFibroblasts of patientsTherapeutic targetPatientsMore studiesAltered transcriptomeDisease phenotypeSignificant differencesCell linesMitochondrial functionDysfunctionOriginal fibroblastsDistinct transcriptomesDegeneration
2004
The apical and basal environments of the retinal pigment epithelium regulate the maturation of tight junctions during development
Rahner C, Fukuhara M, Peng S, Kojima S, Rizzolo LJ. The apical and basal environments of the retinal pigment epithelium regulate the maturation of tight junctions during development. Journal Of Cell Science 2004, 117: 3307-3318. PMID: 15226402, DOI: 10.1242/jcs.01181.Peer-Reviewed Original ResearchAnimalsCell SeparationCells, CulturedChick EmbryoCulture Media, ConditionedDNA PrimersElectric ImpedanceElectrophysiologyFibroblastsFreeze FracturingGene Expression Regulation, DevelopmentalMicroscopy, FluorescenceNerve Tissue ProteinsPigment Epithelium of EyePolymerase Chain ReactionRetinaReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTight JunctionsTime Factors
1985
Biosynthesis and intracellular sorting of growth hormone-viral envelope glycoprotein hybrids.
Rizzolo L, Finidori J, Gonzalez A, Arpin M, Ivanov I, Adesnik M, Sabatini D. Biosynthesis and intracellular sorting of growth hormone-viral envelope glycoprotein hybrids. Journal Of Cell Biology 1985, 101: 1351-1362. PMID: 2995406, PMCID: PMC2113904, DOI: 10.1083/jcb.101.4.1351.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological TransportCell LineChlorocebus aethiopsDogsEndoplasmic ReticulumFibroblastsGenes, SyntheticGenetic VectorsGlycoproteinsGrowth HormoneHemagglutinins, ViralIntracellular MembranesKidneyMembrane ProteinsOrthomyxoviridaeProtein Processing, Post-TranslationalRecombinant ProteinsTransfectionVesicular stomatitis Indiana virusViral Envelope ProteinsConceptsCarboxy-terminal portionGolgi apparatusMembrane proteinsChimeric geneTranscription-translation experimentsPlasma membrane proteinsEndoplasmic reticulum membraneMembrane protein segmentsVesicular stomatitis virus envelope glycoproteinER membraneHybrid proteinIntracellular sortingCytoplasmic portionJuxtanuclear regionTransmembrane portionMembrane polypeptidesCarboxy terminusChimeric proteinHybrid polypeptideInsertion signalProtein segmentsSecretory polypeptidesCytoplasmic vesiclesReticulum membraneER cisternae