Neferine, is not inducer but blocker for macroautophagic flux targeting on lysosome malfunction
Xu T, Singh D, Liu J, Li H, Peng S, Rizzolo LJ, Wang SB. Neferine, is not inducer but blocker for macroautophagic flux targeting on lysosome malfunction. Biochemical And Biophysical Research Communications 2017, 495: 1516-1521. PMID: 29197576, DOI: 10.1016/j.bbrc.2017.11.169.Peer-Reviewed Original ResearchMeSH KeywordsAntioxidantsAutophagyBenzylisoquinolinesDose-Response Relationship, DrugHEK293 CellsHeLa CellsHumansLysosomesMetabolic Flux AnalysisMicrotubule-Associated ProteinsConceptsLC3-IIMultiple pharmacological effectsAMPK/mTORNeferine treatmentKnockdown of ATG5Pharmacological effectsCancer cellsNeferineStrong inducerAutophagic fluxCathepsin DPhagocytic cargoLysosome maturationLysosome malfunctionExposureMacroautophagic fluxInducerMaturationAdaptor proteinArrhythmiasBlockersCancer