Inhibition of platelet deposition and lysis of intracoronary thrombus during balloon angioplasty using urokinase-coated hydrogel balloons.
Mitchel J, Azrin M, Fram D, Hong M, Wong S, Barry J, Bow L, Curley T, Kiernan F, Waters D. Inhibition of platelet deposition and lysis of intracoronary thrombus during balloon angioplasty using urokinase-coated hydrogel balloons. Circulation 1994, 90: 1979-1988. PMID: 7923688, DOI: 10.1161/01.cir.90.4.1979.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAngioplasty, BalloonAnimalsBlood PlateletsCoronary AngiographyCoronary ThrombosisFemaleHumansHydrogel, Polyethylene Glycol DimethacrylateMaleMiddle AgedPolyethylene GlycolsRabbitsSwineThrombolytic TherapyUrokinase-Type Plasminogen ActivatorConceptsLocal urokinase deliveryVivo balloon angioplastyIntracoronary thrombusBalloon angioplastyPlatelet depositionThrombotic closureDistal embolizationAngioplasty siteAbrupt closureArterial wallHydrogel balloonContralateral control arteriesContralateral control vesselsIntramural drug deliveryVivo studiesConventional balloon angioplastyNew Zealand rabbitsU urokinaseConventional angioplastyBalloon dilatationClinical efficacyReflow phenomenonIliac arteryBlood exposureControl arteriesDecreased platelet deposition and smooth muscle cell proliferation after intramural heparin delivery with hydrogel-coated balloons.
Azrin M, Mitchel J, Fram D, Pedersen C, Cartun R, Barry J, Bow L, Waters D, McKay R. Decreased platelet deposition and smooth muscle cell proliferation after intramural heparin delivery with hydrogel-coated balloons. Circulation 1994, 90: 433-441. PMID: 8026030, DOI: 10.1161/01.cir.90.1.433.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonAnimalsArteriesBlood PlateletsCell DivisionCoronary VesselsHeparinHydrogel, Polyethylene Glycol DimethacrylateMicrospheresMuscle, Smooth, VascularPolyethylene GlycolsPostoperative PeriodSwineConceptsSmooth muscle cell proliferationMuscle cell proliferationBalloon angioplastyHeparin deliveryPlatelet depositionBalloon dilatationCell proliferationBalloon surfaceMedial smooth muscle cell proliferationLocal heparin deliveryTime of angioplastyVivo balloon angioplastyHydrogel balloonLocal intramural deliveryPorcine peripheral arteriesCell nuclear antigenIntraluminal deliveryAngioplasty injuryBalloon injuryPeripheral arteriesIntramural depositionContralateral vesselIntact circulationImmunohistochemical stainingAngioplasty