In vitro reduction of endotoxin concentrations with the 5S fragment of immunoglobulin G
Xuan D, Nicolau D, Tessier P, Bow L, Quintiliani R, Nightingale C. In vitro reduction of endotoxin concentrations with the 5S fragment of immunoglobulin G. Antimicrobial Agents And Chemotherapy 1997, 41: 1512-1516. PMID: 9210676, PMCID: PMC163950, DOI: 10.1128/aac.41.7.1512.Peer-Reviewed Original ResearchConceptsNegative sepsisAntiendotoxin activityEndotoxin releaseTreatment of sepsisEndotoxin concentrationsTime-kill studiesDose-effect relationRapid bactericidal effectBacterial colony countsColony countsAdjuvant therapyMean reductionSepsisE. coli CFUCFU/Further studiesMajor targetTherapyVitro reductionCefotaximeConcentration curveImmunoglobulin G.Bactericidal effectBactericidal actionBacterial proliferation