2017
Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear
Tan WJ, Song L, Graham M, Schettino A, Navaratnam D, Yarbrough WG, Santos-Sacchi J, Ivanova AV. Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear. Antioxidants & Redox Signaling 2017, 27: 489-509. PMID: 28135838, PMCID: PMC5564041, DOI: 10.1089/ars.2016.6851.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAnimalsAntioxidantsDisease Models, AnimalEar, InnerEvoked Potentials, Auditory, Brain StemGene Knockout TechniquesHearing LossHumansMiceMicroscopy, Electron, TransmissionMitochondriaOxidative StressProto-Oncogene Proteins c-aktPTEN PhosphohydrolaseSignal TransductionSpiral GanglionTOR Serine-Threonine KinasesTumor Suppressor ProteinsConceptsAge-related hearing lossAuditory brainstem responseHearing lossKO miceEndocochlear potentialOxidative stressMitochondrial dysfunctionMitochondrial dysfunction/oxidative stressEnergy sensing pathwaysNovel therapeutic strategiesMolecular mechanismsPremature hearing lossCochlear stria vascularisMajor hearing lossChronic mitochondrial dysfunctionMetabolic etiologyWorldwide epidemicBrainstem responseClinical trialsVascular pathologyTherapeutic strategiesPathological alterationsABR parametersAO treatmentStria vascularis
1987
Electrical coupling differs in the in vitro and in vivo organ of Corti
Santos-Sacchi J. Electrical coupling differs in the in vitro and in vivo organ of Corti. Hearing Research 1987, 25: 227-232. PMID: 3558131, DOI: 10.1016/0378-5955(87)90094-3.Peer-Reviewed Original ResearchConceptsOrgan of CortiBony cochleaVivo preparationInner earLateral wallGuinea pig organAnesthetized animalsPig organsStria vascularisEndolymphatic potentialCortiReissner's membraneMedium 199Perfusion chamberCochleaVivo experimentsApical sideOrgansKCl electrodesM KCl electrodesElectrical couplingUnique microenvironmentCellsEarThird turn
1982
An electronmicroscopic study of microtubules in the development of marginal cells of the mouse stria vascularis
Santos-Sacchi J. An electronmicroscopic study of microtubules in the development of marginal cells of the mouse stria vascularis. Hearing Research 1982, 6: 7-13. PMID: 7054137, DOI: 10.1016/0378-5955(82)90003-x.Peer-Reviewed Original ResearchConceptsMouse stria vascularisPlasma membraneCellular extensionsNumerous cellular processesMarginal cellsSheet-like extensionsCellular processesCell peripheryLength of microtubulesGolgi bodiesDepolymerization of microtubulesCytoplasmic microtubulesMicrotubulesNumerous microtubulesCell processesOrganellesMitochondriaStria vascularisCellsMembraneAdult miceCytoplasmVesiclesPlasmalemmaMicrotubles