2020
Maturation of Voltage-induced Shifts in SLC26a5 (Prestin) Operating Point during Trafficking and Membrane Insertion
Zhai F, Song L, Bai JP, Dai C, Navaratnam D, Santos-Sacchi J. Maturation of Voltage-induced Shifts in SLC26a5 (Prestin) Operating Point during Trafficking and Membrane Insertion. Neuroscience 2020, 431: 128-133. PMID: 32061780, PMCID: PMC8720582, DOI: 10.1016/j.neuroscience.2020.02.003.Peer-Reviewed Original ResearchConceptsMembrane motor proteinVoltage-dependent proteinsMembrane insertionOuter hair cellsMotor proteinsPrestin densityHEK cell linesConformational changesBiophysical forcesOHC electromotilityProteinCell linesMembrane potentialCooperative interactionsPrestinHair cellsCochlear amplificationTransmembrane voltageNonlinear capacitanceMammalsTraffickingVoltage-induced shiftElectromotilityMaturationMembrane
2001
Effects of membrane potential and tension on prestin, the outer hair cell lateral membrane motor protein
Santos‐Sacchi J, Shen W, Zheng J, Dallos P. Effects of membrane potential and tension on prestin, the outer hair cell lateral membrane motor protein. The Journal Of Physiology 2001, 531: 661-666. PMID: 11251048, PMCID: PMC2278494, DOI: 10.1111/j.1469-7793.2001.0661h.x.Peer-Reviewed Original ResearchConceptsMembrane tensionMembrane motor proteinMembrane-bound proteinsHuman embryonic kidney cellsLateral plasma membraneEmbryonic kidney cellsMolecular basisPlasma membraneProtein prestinMotor proteinsConformational changesHigh-resolution analysisPrestin activityPrestinKidney cellsMembrane potential
1998
Effects of membrane potential on the voltage dependence of motility‐related charge in outer hair cells of the guinea‐pig
Santos‐Sacchi J, Kakehata S, Takahashi S. Effects of membrane potential on the voltage dependence of motility‐related charge in outer hair cells of the guinea‐pig. The Journal Of Physiology 1998, 510: 225-235. PMID: 9625879, PMCID: PMC2231020, DOI: 10.1111/j.1469-7793.1998.225bz.x.Peer-Reviewed Original Research
1986
The temperature dependence of electrical coupling in the organ of Corti
Santos-Sacchi J. The temperature dependence of electrical coupling in the organ of Corti. Hearing Research 1986, 21: 205-211. PMID: 2424883, DOI: 10.1016/0378-5955(86)90219-4.Peer-Reviewed Original ResearchConceptsOrgan of CortiElectrical couplingMembrane potentialExtracellular Ca2Intracellular storesInput resistanceBathing medium
1985
The effects of cytoplasmic acidification upon electrical coupling in the organ of Corti
Santos-Sacchi J. The effects of cytoplasmic acidification upon electrical coupling in the organ of Corti. Hearing Research 1985, 19: 207-215. PMID: 3934121, DOI: 10.1016/0378-5955(85)90140-6.Peer-Reviewed Original Research
1982
Intracellular Recordings from Cochlear Outer Hair Cells
Dallos P, Santos-Sacchi J, Flock Å. Intracellular Recordings from Cochlear Outer Hair Cells. Science 1982, 218: 582-584. PMID: 7123260, DOI: 10.1126/science.7123260.Peer-Reviewed Original Research