2002
Voltage-dependent changes in specific membrane capacitance caused by prestin, the outer hair cell lateral membrane motor
Santos-Sacchi J, Navarrete E. Voltage-dependent changes in specific membrane capacitance caused by prestin, the outer hair cell lateral membrane motor. Pflügers Archiv - European Journal Of Physiology 2002, 444: 99-106. PMID: 11976921, DOI: 10.1007/s00424-002-0804-2.Peer-Reviewed Original ResearchConceptsMembrane motorHEK cellsOuter hair cellsArea motor modelLateral membrane areaLateral plasma membranePlasma membraneProtein prestinConstant membrane thicknessConformational changesCharge movementMembrane capacitanceMolecular motorsPrestinMembrane surface areaVoltage sensorDeiters' cellsHair cellsCellsExtreme hyperpolarizationMembrane voltageVoltage-dependent changesMembrane area
2000
Nitric oxide uncouples gap junctions of supporting Deiters cells from Corti's organ
Blasits S, Maune S, Santos-Sacchi J. Nitric oxide uncouples gap junctions of supporting Deiters cells from Corti's organ. Pflügers Archiv - European Journal Of Physiology 2000, 440: 710-712. PMID: 11007311, DOI: 10.1007/s004240000355.Peer-Reviewed Original ResearchConceptsDeiters' cellsCorti's organNO/cGMP pathwayNitric oxide donor sodium nitroprussideWhole-cell voltage-clamp conditionsNO synthase inhibitorUncouple gap junctionsNormal sensory functionDonor sodium nitroprussideGap junctionsVoltage-clamp conditionsOtotoxic mechanismsMinutes of applicationCGMP pathwayGap junctional communicationSodium nitroprussideSynthase inhibitorCochlear homeostasisSensory functionElectrical uncouplingNitric oxideCGMP analogJunctional communicationOrgansCells