2019
1768-P: Inflammation in Visceral and Subcutaneous Fat and Human Insulin Resistance
MCLAUGHLIN T, ZANLEY E, PETLURA C, TOLENTINO L, CHOI O, CHUANG J, XU Y, MORTON J, ENGLEMAN E. 1768-P: Inflammation in Visceral and Subcutaneous Fat and Human Insulin Resistance. Diabetes 2019, 68 DOI: 10.2337/db19-1768-p.Peer-Reviewed Original ResearchVisceral adipose tissueInsulin resistanceWhole-body insulin sensitivityBariatric surgery patientsImmune cell profilesSystemic insulin resistanceTotal fat massAmerican Heart AssociationPlasma glucose testSystemic glucose metabolismHuman insulin resistanceSurgery patientsInflammation contributesHeart AssociationCytokine releaseImmune cellsInsulin sensitivityMacrophage numbersFat massBacterial antigensAdipocyte stressGlucose testGlucose metabolismHuman studiesAdipose tissue
2017
Adipose tissue macrophages impair preadipocyte differentiation in humans
Liu LF, Craig CM, Tolentino LL, Choi O, Morton J, Rivas H, Cushman SW, Engleman EG, McLaughlin T. Adipose tissue macrophages impair preadipocyte differentiation in humans. PLOS ONE 2017, 12: e0170728. PMID: 28151993, PMCID: PMC5289462, DOI: 10.1371/journal.pone.0170728.Peer-Reviewed Original ResearchConceptsImpaired adipocyte differentiationSystemic insulin resistanceInsulin resistanceAdipocyte differentiationPreadipocyte differentiationMacrophage removalImpaired preadipocyte differentiationProinflammatory immune cellsAdipose tissue inflammationAbsence of CD14Insulin-resistant humansAdipose tissue samplesOil Red ODifferentiation of preadipocytesBariatric surgeryProinflammatory cytokinesInflammatory cytokinesTissue inflammationImmune cellsCytokine secretionAdiponectin secretionAdipogenic gene expressionPhysiologic mechanismsAdipose tissueVAT adipocytes
2014
T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans
McLaughlin T, Liu LF, Lamendola C, Shen L, Morton J, Rivas H, Winer D, Tolentino L, Choi O, Zhang H, Hui Yen Chng M, Engleman E. T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans. Arteriosclerosis Thrombosis And Vascular Biology 2014, 34: 2637-2643. PMID: 25341798, PMCID: PMC4445971, DOI: 10.1161/atvbaha.114.304636.Peer-Reviewed Original ResearchConceptsCD8 T cellsSubcutaneous adipose tissueT cell profileInsulin resistanceT cellsAdipose tissueSystemic inflammationPeripheral bloodPlasma high-sensitivity C-reactive protein concentrationsHigh-sensitivity C-reactive protein concentrationsAnti-inflammatory T cellsAnti-inflammatory interleukin-10C-reactive protein concentrationsDiet-induced obese miceObesity-associated metabolic diseasesInsulin-mediated glucose disposalProinflammatory T helperPlasma interleukin-6T cell subsetsInsulin suppression testT-cell phenotypeSystemic insulin resistanceAdipose tissue biopsiesObese human subjectsReal-time polymerase chain reaction