2019
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials
Lin A, Giuliano CJ, Palladino A, John KM, Abramowicz C, Yuan ML, Sausville EL, Lukow DA, Liu L, Chait AR, Galluzzo ZC, Tucker C, Sheltzer JM. Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials. Science Translational Medicine 2019, 11 PMID: 31511426, PMCID: PMC7717492, DOI: 10.1126/scitranslmed.aaw8412.Peer-Reviewed Original ResearchConceptsClinical trialsCancer drugsDose-limiting toxicityLack of efficacyDrug Administration approvalNumber of therapiesCancer cell proliferationMultiple cancer typesMechanism of actionClinical benefitAdministration approvalCommon causeTrial failuresSmall molecule inhibitorsClinical testingCDK11 expressionHuman patientsPreclinical settingCancer typesU.S. FoodTarget toxicityNew drugsDrugsCell proliferationDrug-indication pairs
2012
Transcriptional consequences of aneuploidy
Sheltzer J, Torres E, Dunham M, Amon A. Transcriptional consequences of aneuploidy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 12644-12649. PMID: 22802626, PMCID: PMC3411958, DOI: 10.1073/pnas.1209227109.Peer-Reviewed Original ResearchConceptsConsequences of aneuploidyRelated gene expression patternsAneuploid cellsSimilar cellular pathwaysGene expression patternsGene expression dataDiverse organismsDifferent organismsTranscriptional consequencesDifferent chromosomesCell physiologyCellular pathwaysExpression patternsGene expressionCell cycleExpression dataDifferent aneuploidiesAntiproliferative responseCell proliferationGenesOrganismsSpeciesAneuploidySpecific chromosomal aberrationsChromosomal aberrations
2011
The aneuploidy paradox: costs and benefits of an incorrect karyotype
Sheltzer J, Amon A. The aneuploidy paradox: costs and benefits of an incorrect karyotype. Trends In Genetics 2011, 27: 446-453. PMID: 21872963, PMCID: PMC3197822, DOI: 10.1016/j.tig.2011.07.003.Peer-Reviewed Original ResearchConceptsCell proliferationRole of aneuploidyHallmarks of cancerExperimental evolutionEnhanced proliferative capacityCellular phenotypesChromosomal instabilityAneuploid cellsNormal cellsKaryotypic imbalancesProliferative capacityAneuploidyDiverse effectsProliferationCellsPhenotypeMicroorganismsKaryotypeHallmark