2024
Digital spatial proteomic profiling reveals immune checkpoints as biomarkers in lymphoid aggregates and tumor microenvironment of desmoplastic melanoma
Su D, Schoenfeld D, Ibrahim W, Cabrejo R, Djureinovic D, Baumann R, Rimm D, Khan S, Halaban R, Kluger H, Olino K, Galan A, Clune J. Digital spatial proteomic profiling reveals immune checkpoints as biomarkers in lymphoid aggregates and tumor microenvironment of desmoplastic melanoma. Journal For ImmunoTherapy Of Cancer 2024, 12: e008646. PMID: 38519058, PMCID: PMC10961546, DOI: 10.1136/jitc-2023-008646.Peer-Reviewed Original ResearchConceptsCTLA-4 expression levelsCancer-associated fibroblastsAssociated with worse survivalExpression of immune checkpointsLAG-3 expressionDesmoplastic melanomaLymphoid aggregatesCTLA-4PD-1Immune checkpointsIntratumoral leukocytesLAG-3Tumor compartmentsWorse survivalCD20+B cellsIncreased expression of immune checkpointsProgrammed cell death protein 1Macrophage/monocyte markerSentinel lymph node positivityCell death protein 1Associated with poor prognosisLymph node positivityDense fibrous stromaPotential prognostic significanceCore of tumors
2016
Malignant Melanoma
Pavri SN, Clune J, Ariyan S, Narayan D. Malignant Melanoma. Plastic & Reconstructive Surgery 2016, 138: 330e-340e. PMID: 27465194, DOI: 10.1097/prs.0000000000002367.Peer-Reviewed Original ResearchConceptsWide local excisionSentinel lymph node biopsyLymph node biopsySentinel lymphLocal excisionAuricular melanomaNode biopsyMedical therapyMetastatic melanomaSubungual melanomaMalignant melanomaDesmoplastic melanomaNational Comprehensive Cancer Network guidelinesIntermediate-thickness melanomasPostoperative radiation therapyGold standardHigh-risk lesionsCutaneous malignant melanomaFull-thickness skinThickness melanomaPregnant patientsInitial managementPreoperative lymphoscintigraphySurgical treatmentOngoing trials