2017
Covalent modification of pericardial patches for sustained rapamycin delivery inhibits venous neointimal hyperplasia
Bai H, Lee JS, Chen E, Wang M, Xing Y, Fahmy TM, Dardik A. Covalent modification of pericardial patches for sustained rapamycin delivery inhibits venous neointimal hyperplasia. Scientific Reports 2017, 7: 40142. PMID: 28071663, PMCID: PMC5223139, DOI: 10.1038/srep40142.Peer-Reviewed Original ResearchConceptsSite-specific deliveryEDC/NHS chemistryComposite delivery systemNanoparticlesDelivery of rapamycinNHS chemistryDelivery systemCardiovascular implantsNext generationRapamycin deliveryDeliveryPositive endotheliumPatchesTherapeutic agentsNeointimal hyperplasiaPericardial patchCovalent modificationTherapeuticsSmooth muscle cell proliferationSurfaceVenous neointimal hyperplasiaMuscle cell proliferation
2016
Pericardial patch venoplasty heals via attraction of venous progenitor cells
Bai H, Wang M, Foster TR, Hu H, He H, Hashimoto T, Hanisch JJ, Santana JM, Xing Y, Dardik A. Pericardial patch venoplasty heals via attraction of venous progenitor cells. Physiological Reports 2016, 4: e12841. PMID: 27354544, PMCID: PMC4923240, DOI: 10.14814/phy2.12841.Peer-Reviewed Original ResearchConceptsNeointimal thicknessVenous patchArteriovenous fistulaPericardial patchProgenitor cellsDay 7Aggressive venous neointimal hyperplasiaVenous neointimal hyperplasiaAVF ligationArterial pressureArterial patchPatch venoplastyCardiovascular surgeryNeointimal hyperplasiaBlood flowThicker neointimaBlood vesselsVenous identityCellsVenoplastyPseudoaneurysmFistulaSurgeryArteryHyperplasia