2024
Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis
Hassab A, Hur D, Vallabhajosyula P, Tellides G, Assi R. Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis. JCI Insight 2024, 9: e172437. PMID: 38592807, PMCID: PMC11141924, DOI: 10.1172/jci.insight.172437.Peer-Reviewed Original ResearchMeSH KeywordsAgedAortaAtherosclerosisFemaleFibrosisHumansMaleMiddle AgedMyocytes, Smooth MuscleNeointimaTunica IntimaTunica MediaConceptsDepartment of SurgerySmooth muscle cellsCellular response to injuryResponse to injuryImmunofluorescence confocal microscopyVessel wall repairPrimary lesionAscending aortaConduit functionAneurysmal diseaseDense fibrosisRadiological signsMural hematomaTear progressionMuscle cellsNon-hemorrhagicErythrocyte extravasationWall repairAortaTear completionInduce atherosclerosisHealed lesionsScattered leukocytesMinimal injuryConclusionThese findings
2023
Biomechanical and transcriptional evidence that smooth muscle cell death drives an osteochondrogenic phenotype and severe proximal vascular disease in progeria
Murtada S, Kawamura Y, Cavinato C, Wang M, Ramachandra A, Spronck B, Li D, Tellides G, Humphrey J. Biomechanical and transcriptional evidence that smooth muscle cell death drives an osteochondrogenic phenotype and severe proximal vascular disease in progeria. Biomechanics And Modeling In Mechanobiology 2023, 22: 1333-1347. PMID: 37149823, PMCID: PMC10544720, DOI: 10.1007/s10237-023-01722-5.Peer-Reviewed Original ResearchConceptsPulse wave velocitySmooth muscle cell deathMuscle cell deathDisease processOsteochondrogenic phenotypeAdverse extracellular matrix remodelingImportant cardiovascular implicationsProgressive aortic diseaseProximal elastic arteriesVentricular diastolic dysfunctionProgressive disease processSmooth muscle cellsCell deathCardiovascular sequelaeDiastolic dysfunctionCardiovascular implicationsExtracellular matrix remodelingAortic diseasePrimary diagnosisVascular diseaseAccumulation of proteoglycansMuscular arteriesAortic structureAortic wallLate calcification
2021
Adventitial remodeling protects against aortic rupture following late smooth muscle-specific disruption of TGFβ signaling
Kawamura Y, Murtada S, Gao F, Liu X, Tellides G, Humphrey J. Adventitial remodeling protects against aortic rupture following late smooth muscle-specific disruption of TGFβ signaling. Journal Of The Mechanical Behavior Of Biomedical Materials 2021, 116: 104264. PMID: 33508556, PMCID: PMC7959590, DOI: 10.1016/j.jmbbm.2020.104264.Peer-Reviewed Original ResearchMeSH KeywordsAdventitiaAnimalsAortic RuptureHumansMiceMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleTransforming Growth Factor betaConceptsAortic dissectionMouse modelAortic wallCompensatory changesThoracic aortic dissectionMuscle-specific disruptionSmooth muscle cellsLoss of TGFβMedial integrityAortic ruptureClinical presentationMuscle cellsQuantitative histologyMatrix turnoverTGFβ receptorsDissectionWall stressTGFβType IIndividual subjectsSpecific disruptionVivo valuesExaminationRupture