Featured Publications
CORR Insights®: Imposter Syndrome Among Surgeons is Associated With Intolerance of Uncertainty and Lower Confidence in Problem Solving
Friedlaender GE. CORR Insights®: Imposter Syndrome Among Surgeons is Associated With Intolerance of Uncertainty and Lower Confidence in Problem Solving. Clinical Orthopaedics And Related Research® 2022, 481: 672-674. PMID: 36166271, PMCID: PMC10013620, DOI: 10.1097/corr.0000000000002427.Peer-Reviewed Original ResearchReply to the Letter to the Editor: Art in Science: Quackery and Promises Not Kept
Friedlaender GE, Friedlaender LK. Reply to the Letter to the Editor: Art in Science: Quackery and Promises Not Kept. Clinical Orthopaedics And Related Research® 2022, 480: 2060-2060. PMID: 36001023, PMCID: PMC9473757, DOI: 10.1097/corr.0000000000002350.Peer-Reviewed Original ResearchArt in Science: Quackery and Promises Not Kept
Friedlaender GE, Friedlaender LK. Art in Science: Quackery and Promises Not Kept. Clinical Orthopaedics And Related Research® 2022, 480: 1458-1460. PMID: 35767816, PMCID: PMC9278922, DOI: 10.1097/corr.0000000000002290.Peer-Reviewed Original ResearchArt in Science: Alchemy As Seen Through The Eyes of David Teniers the Younger
Friedlaender GE, Friedlaender LK. Art in Science: Alchemy As Seen Through The Eyes of David Teniers the Younger. Clinical Orthopaedics And Related Research® 2021, 480: 235-236. PMID: 34870955, PMCID: PMC8747614, DOI: 10.1097/corr.0000000000002069.Peer-Reviewed Original ResearchArt in Science: The Boxer at Rest
Chan SM, Moran J, Friedlaender LK, Friedlaender GE. Art in Science: The Boxer at Rest. Clinical Orthopaedics And Related Research® 2021, 479: 1441-1443. PMID: 34106904, PMCID: PMC8208444, DOI: 10.1097/corr.0000000000001847.Peer-Reviewed Original ResearchArt in Science-Humility: As Portrayed by Pietro Lorenzetti.
Flores M, Friedlaender LK, Friedlaender GE. Art in Science-Humility: As Portrayed by Pietro Lorenzetti. Clinical Orthopaedics And Related Research® 2021, 479: 458-460. PMID: 33543878, PMCID: PMC7899731, DOI: 10.1097/corr.0000000000001666.Peer-Reviewed Original ResearchArt in Science-Goya to Dr. Arrieta: An Illustration of Patient-Physician Trust.
Chan SM, Friedlaender GE, Friedlaender LK. Art in Science-Goya to Dr. Arrieta: An Illustration of Patient-Physician Trust. Clinical Orthopaedics And Related Research® 2020, 478: 2221-2224. PMID: 32898044, PMCID: PMC7491894, DOI: 10.1097/corr.0000000000001470.Peer-Reviewed Original ResearchArt in Science: Pieter Bruegel the Elder and the Plague.
Friedlaender GE, Friedlaender LK. Art in Science: Pieter Bruegel the Elder and the Plague. Clinical Orthopaedics And Related Research® 2020, 478: 1416-1418. PMID: 32574469, PMCID: PMC7310395, DOI: 10.1097/corr.0000000000001325.Peer-Reviewed Original Research
2024
Progression of Femoral Osteolytic Metastases after Intramedullary Nailing and Subsequent Salvage Techniques
Jiang W, Latich I, Lindskog D, Friedlaender G, Lee F. Progression of Femoral Osteolytic Metastases after Intramedullary Nailing and Subsequent Salvage Techniques. Cancers 2024, 16: 2812. PMID: 39199585, PMCID: PMC11352437, DOI: 10.3390/cancers16162812.Peer-Reviewed Original ResearchPre-existing lesionsOsteolytic metastasesIntramedullary nailingCancer progressionTwo-week postoperative follow-upFollow-upSalvage techniqueFunction scoresRadiation-resistant tumorsPoor surgical candidacyPostoperative follow-upNail failureTransport of cancer cellsPostoperative radiationSurgical salvageCombined painSingle-institutionSurgical outcomesIntramedullary nail insertionPathological fracturesRetrospective studySurgical candidacyAdult patientsPercutaneous salvageOsteolytic lesions
2023
Bone Mass Changes Following Percutaneous Radiofrequency Ablation, Osteoplasty, Reinforcement, and Internal Fixation of Periacetabular Osteolytic Metastases
Jiang W, Caruana D, Dussik C, Conway D, Latich I, Chapiro J, Lindskog D, Friedlaender G, Lee F. Bone Mass Changes Following Percutaneous Radiofrequency Ablation, Osteoplasty, Reinforcement, and Internal Fixation of Periacetabular Osteolytic Metastases. Journal Of Clinical Medicine 2023, 12: 4613. PMID: 37510728, PMCID: PMC10380351, DOI: 10.3390/jcm12144613.Peer-Reviewed Original ResearchPercutaneous radiofrequency ablationBone mass changesCT scanMedian survivalHounsfield unitsOsteolytic metastasesRadiofrequency ablationBone massCancer-induced bone lossSuperior median survivalAvailable CT scansThree-dimensional volumetric analysisInternal screw fixationPeriacetabular areaPercutaneous stabilizationBone lossInternal fixationSingle institutionOrthopedic interventionsScrew fixationPatientsMonthsVolumetric analysisSurvivalScansComparison of Percutaneous Interventional Ablation-Osteoplasty-Reinforcement-Internal Fixation (AORIF), Long Intramedullary Nailing, and Hemiarthroplasty for the Treatment of Focal Metastatic Osteolytic Lesions in the Femoral Head and Neck
Jiang W, Friedlaender G, Lindskog D, Latich I, Lee F. Comparison of Percutaneous Interventional Ablation-Osteoplasty-Reinforcement-Internal Fixation (AORIF), Long Intramedullary Nailing, and Hemiarthroplasty for the Treatment of Focal Metastatic Osteolytic Lesions in the Femoral Head and Neck. CardioVascular And Interventional Radiology 2023, 46: 649-657. PMID: 37052716, DOI: 10.1007/s00270-023-03425-x.Peer-Reviewed Original ResearchConceptsOsteolytic lesionsFemoral headSurgical complicationsRevision proceduresLong intramedullary nailingResultsSixty-seven patientsPost-operative complicationsEffective alternative treatmentTraditional surgical approachesAmbulatory scoreCombined painPrimary outcomeMedical complicationsMetastatic lesionsOncologic careRetrospective studyIntramedullary nailingSurgical approachFunction scoresNeck lesionsEarly improvementIM groupHemiarthroplastyComparative efficacyAlternative treatmentPercutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies.
Dussik C, Toombs C, Alder K, Yu K, Berson E, Ibe I, Li F, Lindskog D, Friedlaender G, Latich I, Lee F. Percutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies. Radiology 2023, 307: e221401. PMID: 36916888, DOI: 10.1148/radiol.221401.Peer-Reviewed Original ResearchConceptsOsteolytic neoplasmAmbulatory functionInternal fixationEastern Cooperative Oncology Group scoreIndex scoreConversion hip arthroplastyRetrospective observational studySurgical site infectionKaplan-Meier analysisLong-term painQuality of lifeLong-term improvementWilcoxon signed-rank testNonambulatory patientsSecondary outcomesPrimary outcomeSite infectionOncologic careECOG scorePercutaneous ablationPeriacetabular metastasisProtrusio acetabuliFunctional improvementSigned-rank testClinical dataWhat’s Important: Ortho, I Screwed Up
Pirkle S, Chen A, Samora J, Friedlaender G. What’s Important: Ortho, I Screwed Up. Journal Of Bone And Joint Surgery 2023, 105: 962-964. PMID: 36728460, DOI: 10.2106/jbjs.22.01214.Peer-Reviewed Original Research
2020
Bone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus.
Samuel AM, Munger AM, Lee FY, Friedlaender GE, Ibe IK, Lindskog DM. Bone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus. Orthopedics 2020, 43: e498-e502. PMID: 32882054, DOI: 10.3928/01477447-20200827-05.Peer-Reviewed Original ResearchConceptsRadionuclide bone scanBone scanMRI scansPositive findingsNegative findingsMagnetic resonance imaging (MRI) scansBone scan findingsProgression of lesionsResonance imaging scansDiagnosis of enchondromaAcademic medical centerBivariate logistic regressionAssociation of boneScan findingsAggressive featuresRadiographic findingsEndosteal scallopingBenign enchondromaImaging scansMedical recordsMedical CenterMalignant lesionsCartilaginous lesionsEnchondromaPatientsMinimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones
Lee FY, Latich I, Toombs C, Mungur A, Conway D, Alder K, Ibe I, Lindskog D, Friedlaender G. Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones. Journal Of Vascular And Interventional Radiology 2020, 31: 649-658.e1. PMID: 32139256, DOI: 10.1016/j.jvir.2019.11.029.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesAdultAgedAged, 80 and overBone CementsBone NeoplasmsBone RemodelingBone ScrewsCalcaneusCementoplastyFemaleFemoral NeoplasmsFemurFracture Fixation, InternalHumansMaleMiddle AgedOsteolysisPelvic BonesPostoperative ComplicationsProspective StudiesRecovery of FunctionTibiaTime FactorsTreatment OutcomeWeight-BearingConceptsOsteolytic lesionsInternal fixationVisual analog scale pain scoreMusculoskeletal Tumor Society scoreProspective clinical cohort studyFunctional ambulation scoreOsteolytic skeletal lesionsPainful osteolytic lesionsScale pain scoresClinical cohort studyInvasive percutaneous approachWeight-bearing boneInternal fixation screwsBalloon osteoplastyPain scoresCohort studyProphylactic stabilizationSevere painSociety ScoreConsecutive patientsSurgical treatmentEarly outcomesTreatment optionsPercutaneous approachFunctional improvement
2018
Predictors of Lymph Node Involvement by Soft Tissue Sarcoma: An Analysis of the National Cancer Database (NCDB)
Miccio J, Jairam V, Gao S, Augustyn A, Oladeru O, Onderdonk B, Costa J, Han D, Khan S, Friedlaender G, Lindskog D, Deshpande H, Tara H, Osborn H, Roberts K, Patel K. Predictors of Lymph Node Involvement by Soft Tissue Sarcoma: An Analysis of the National Cancer Database (NCDB). International Journal Of Radiation Oncology • Biology • Physics 2018, 102: e335. DOI: 10.1016/j.ijrobp.2018.07.1028.Peer-Reviewed Original ResearchImmuno-oncologic Approach to Musculoskeletal Tumors
Ibe I, Sahlstrom A, Nguyen M, Lindskog D, Friedlaender G, Lee F. Immuno-oncologic Approach to Musculoskeletal Tumors. Techniques In Orthopaedics 2018, 33: 140-147. DOI: 10.1097/bto.0000000000000305.Peer-Reviewed Original ResearchImmune systemImmuno-oncologic therapiesSoft tissue sarcomasHost immune surveillanceActive immune responseTreatment of boneImmune therapyTumor burdenTissue sarcomasTreatment of cancerTreatment optionsMusculoskeletal tumorsComprehensive careImproved outcomesImmune surveillanceImmune responseOrthopedic oncologyMalignant cellsImmunotherapyCancer cellsPrecision medicineDistant sitesPatientsUnderlying mechanismTherapyThe Cost of Innovation Roles of Industry, Regulatory Agencies, and the Clinician
Friedlaender G. The Cost of Innovation Roles of Industry, Regulatory Agencies, and the Clinician. Techniques In Orthopaedics 2018, 33: 132-134. DOI: 10.1097/bto.0000000000000287.Peer-Reviewed Original Research
2017
Commentary: Art in Science: Mondino de' Liuzzi: The Restorer of Anatomy
Friedlaender, GE, Friedlaender, LK: Commentary: Art in Science: Mondino de' Liuzzi: The Restorer of Anatomy. Di Matteo B, Tarabella V, Filardo G, Massimiliano M, Presti ML, Vigano A, Tomba P, Marcacci M. Clin Orthop and Rel Res 475:1791-1795 (2017).Peer-Reviewed Original Research
2016
Case of a Missed Giant Cell Tumor of Bone: An Opportunity to Observe its Natural History Disease.
Russo GS, Rubio DR, Yacob A, Lindskog DM, Alomari AK, Friedlaender GE. Case of a Missed Giant Cell Tumor of Bone: An Opportunity to Observe its Natural History Disease. Connecticut Medicine 2016, 80: 399-403. PMID: 29782126.Peer-Reviewed Case Reports and Technical NotesConceptsGiant cell tumorAnterior cruciate ligamentCell tumorsIncidental findingRoutine preoperative imagingPre-operative MRIInitial MRIPreoperative imagingSecond MRIMetaphyseal lesionsCruciate ligamentEnlarged massBenign neoplasmsRetrospective evaluationNatural historyTumorsYoung womenHistory diseaseMRIBoneLesionsPainPatientsNeoplasmsHistology