2021
Invasive thymoma – Which patients benefit from post-operative radiotherapy?
Muslim Z, Baig MZ, Weber JF, Detterbeck FC, Connery CP, Spera JA, Bhora FY. Invasive thymoma – Which patients benefit from post-operative radiotherapy? Asian Cardiovascular And Thoracic Annals 2021, 29: 935-942. PMID: 33975467, DOI: 10.1177/02184923211017094.Peer-Reviewed Original ResearchConceptsPost-operative radiotherapyWorld Health Organization histologyMasaoka-Koga stageStage III thymomaPropensity-matched cohortStage III diseaseClinical pathological factorsEnd Results (SEER) databasePositive prognostic indicatorUnderwent surgerySurgical treatmentThymoma patientsAdvanced thymomaB3 tumorsPrognostic implicationsResults databaseTumor sizeInvasive thymomaPrognostic indicatorSurvival differencesPatientsRadiotherapyThymomaSurgeryTumors
2019
Report from the European Society of Thoracic Surgeons prospective thymic database 2017: a powerful resource for a collaborative global effort to manage thymic tumours
Ruffini E, Guerrera F, Brunelli A, Passani S, Pellicano D, Thomas P, Van Raemdonck D, Rocco G, Venuta F, Weder W, Detterbeck F, Falcoz PE. Report from the European Society of Thoracic Surgeons prospective thymic database 2017: a powerful resource for a collaborative global effort to manage thymic tumours. European Journal Of Cardio-Thoracic Surgery 2019, 55: 601-609. PMID: 30649256, DOI: 10.1093/ejcts/ezy448.Peer-Reviewed Original ResearchConceptsNeuroendocrine thymic tumoursThymic tumorsAdjuvant treatmentThymic carcinomaStage IStage IIIB tumorsEuropean SocietyStage IV tumorsOverall recurrence rateInvasive surgical approachNew International AssociationCollaborative global effortIIIB tumorsProspective databaseStage IIIAMetastasis classificationRecurrence rateGroup tumorsRare tumorSurgical approachRetrospective databaseInvasive techniquesStage IIIPatientsTumors
2018
Clinical implication of the new TNM classification of thymic malignancies
Detterbeck FC. Clinical implication of the new TNM classification of thymic malignancies. Journal Of Thoracic Disease 2018, 1: s2692-s2695. PMID: 30345107, PMCID: PMC6178297, DOI: 10.21037/jtd.2018.08.36.Peer-Reviewed Original Research
2016
Dataset for reporting of thymic epithelial tumours: recommendations from the International Collaboration on Cancer Reporting (ICCR)
Nicholson AG, Detterbeck F, Marx A, Roden AC, Marchevsky AM, Mukai K, Chen G, Marino M, Bakker M, Yang W, Judge M, Hirschowitz L. Dataset for reporting of thymic epithelial tumours: recommendations from the International Collaboration on Cancer Reporting (ICCR). Histopathology 2016, 70: 522-538. PMID: 27735079, DOI: 10.1111/his.13099.Peer-Reviewed Original ResearchThe IASLC Lung Cancer Staging Project: Methodology and Validation Used in the Development of Proposals for Revision of the Stage Classification of NSCLC in the Forthcoming (Eighth) Edition of the TNM Classification of Lung Cancer
Detterbeck FC, Chansky K, Groome P, Bolejack V, Crowley J, Shemanski L, Kennedy C, Krasnik M, Peake M, Rami-Porta R, Goldstraw P, Rami-Porta R, Asamura H, Ball D, Beer D, Beyruti R, Bolejack V, Chansky K, Crowley J, Detterbeck F, Eberhardt W, Edwards J, Galateau-Sallé F, Giroux D, Gleeson F, Groome P, Huang J, Kennedy C, Kim J, Kim Y, Kingsbury L, Kondo H, Krasnik M, Kubota K, Lerut A, Lyons G, Marino M, Marom E, van Meerbeeck J, Mitchell A, Nakano T, Nicholson A, Nowak A, Peake M, Rice T, Rosenzweig K, Ruffini E, Rusch V, Saijo N, Van Schil P, Sculier J, Shemanski L, Stratton K, Suzuki K, Tachimori Y, Thomas C, Travis W, Tsao M, Turrisi A, Vansteenkiste J, Watanabe H, Wu Y, Baas P, Erasmus J, Hasegawa S, Inai K, Kernstine K, Kindler H, Krug L, Nackaerts K, Pass H, Rice D, Falkson C, Filosso P, Giaccone G, Kondo K, Lucchi M, Okumura M, Blackstone E, Cavaco F, Barrera E, Arca J, Lamelas I, Obrer A, Jorge R, Ball D, Bascom G, Orozco A, Castro M, Blum M, Chimondeguy D, Cvijanovic V, Defranchi S, de Olaiz Navarro B, Campuzano I, Vidueira I, Araujo E, García F, Fong K, Corral G, González S, Gilart J, Arangüena L, Barajas S, Girard P, Goksel T, Budiño M, Casaurrán G, Blanco J, Hernández J, Rodríguez H, Collantes J, Heras M, Elena J, Jakobsen E, Kostas S, Atance P, Ares A, Liao M, Losanovscky M, Lyons G, Magaroles R, De Esteban Júlvez L, Gorospe M, McCaughan B, Kennedy C, Íñiguez R, Sorribes L, Gozalo S, de Arriba C, Delgado M, Alarcón J, Cuesta J, Park J, Pass H, Fernández M, Rosenberg M, Ruffini E, Rusch V, de Cos Escuín J, Vinuesa A, Mitjans M, Strand T, Subotic D, Swisher S, Terra R, Thomas C, Tournoy K, Van Schil P, Velasquez M, Wu Y, Yokoi K, Rami-Porta R, Ball D, Bolejack V, Crowley J, Giroux D, Kim J, Lyons G, Rice T, Suzuki K, Thomas C, Travis W, Wu Y, Asamura H, Ball D, Chansky K, Crowley J, Goldstraw P, Rusch V, van Schil P, Vansteenkiste J, Watanabe H, Wu Y, Zielinski M, Eberhardt W, Chansky K, Crowley J, Kim Y, Kondo H, Mitchell A, Turrisi A, Groome P, Detterbeck F, Bolejack V, Crowley J, Kennedy C, Krasnik M, Peake M, Sculier J, Chansky K, Crowley J, Giroux D, Gleeson F, van Meeerbeeck J, Travis W, Asamura H, Chansky K, Crowley J, Giroux D, Nicholson A, Beyruti R, Chansky K, Crowley J, Kubota K, Turrisi A, Tsao M, Beer D, Crowley J, Wu Y, Travis W, Asamura H, Bankier A, Beasley M, Detterbeck F, Flieder D, Goo J, MacMahon H, Naidich D, Nicholson A, Powell C, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y, Detterbeck F, Arenberg D, Asamura H, Bolejack V, Crowley J, Donington J, Franklin W, Girard N, Marom E, Mazzone P, Nicholson A, Rusch V, Tanoue L, Travis W. The IASLC Lung Cancer Staging Project: Methodology and Validation Used in the Development of Proposals for Revision of the Stage Classification of NSCLC in the Forthcoming (Eighth) Edition of the TNM Classification of Lung Cancer. Journal Of Thoracic Oncology 2016, 11: 1433-1446. PMID: 27448762, DOI: 10.1016/j.jtho.2016.06.028.Peer-Reviewed Original ResearchConceptsLung cancerLung cancer stage classificationIASLC Lung Cancer Staging ProjectLung Cancer Staging ProjectDifferent patient cohortsCancer stage classificationPrognostic Factors CommitteeAnatomic extentHistologic typeTNM classificationDefinition of tumorMetastasis classificationPatient cohortMetastasis categoryStage groupingEnough patientsStage classificationEighth editionCancerPatientsDiscriminatory abilityExternal validationTumorsInternational databasesEvidence of applicabilityThe IASLC Lung Cancer Staging Project: Background Data and Proposals for the Classification of Lung Cancer with Separate Tumor Nodules in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer
Detterbeck FC, Bolejack V, Arenberg DA, Crowley J, Donington JS, Franklin WA, Girard N, Marom EM, Mazzone PJ, Nicholson AG, Rusch VW, Tanoue LT, Travis WD, Asamura H, Rami-Porta R, Committee I, Goldstraw P, Rami-Porta R, Asamura H, Ball D, Beer D, Beyruti R, Bolejack V, Chansky K, Crowley J, Detterbeck F, Eberhardt W, Edwards J, Galateau-Sallé F, Giroux D, Gleeson F, Groome P, Huang J, Kennedy C, Kim J, Kim Y, Kingsbury L, Kondo H, Krasnik M, Kubota K, Lerut A, Lyons G, Marino M, Marom E, van Meerbeeck J, Mitchell A, Nakano T, Nicholson A, Nowak A, Peake M, Rice T, Rosenzweig K, Ruffini E, Rusch V, Saijo N, Van Schil P, Sculier J, Shemanski L, Stratton K, Suzuki K, Tachimori Y, Thomas C, Travis W, Tsao M, Turrisi A, Vansteenkiste J, Watanabe H, Wu Y, Boards A, Baas P, Erasmus J, Hasegawa S, Inai K, Kernstine K, Kindler H, Krug L, Nackaerts K, Pass H, Rice D, Falkson C, Filosso P, Giaccone G, Kondo K, Lucchi M, Okumura M, Blackstone E, Workgroup M, Flieder D, Godoy M, Goo J, Goodman L, Jett J, de Leyn P, Marchevsky A, MacMahon H, Naidich D, Okada M, Perlman M, Powell C, van Schil P, Warth A, Institutions P, Cavaco F, Barrera E, Arca J, Lamelas I, Obrer A, Jorge R, Ball D, Bascom G, Orozco A, Castro M, Blum M, Chimondeguy D, Cvijanovic V, Defranchi S, de Olaiz Navarro B, Campuzano I, Vidueira I, Araujo E, García F, Fong K, Corral G, González S, Gilart J, Arangüena L, Barajas S, Girard P, Goksel T, Budiño M, Casaurrán G, Blanco J, Hernández J, Rodríguez H, Collantes J, Heras M, Elena J, Jakobsen E, Kostas S, Atance P, Ares A, Liao M, Losanovscky M, Lyons G, Magaroles R, De Esteban Júlvez L, Gorospe M, McCaughan B, Kennedy C, Íñiguez R, Sorribes L, Gozalo S, de Arriba C, Delgado M, Alarcón J, Cuesta J, Park J, Pass H, Fernández M, Rosenberg M, Ruffini E, Rusch V, de Cos Escuín J, Vinuesa A, Mitjans M, Strand T, Subotic D, Swisher S, Terra R, Thomas C, Tournoy K, Van Schil P, Velasquez M, Wu Y, Yokoi K. The IASLC Lung Cancer Staging Project: Background Data and Proposals for the Classification of Lung Cancer with Separate Tumor Nodules in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer. Journal Of Thoracic Oncology 2016, 11: 681-692. PMID: 26940530, DOI: 10.1016/j.jtho.2015.12.114.Peer-Reviewed Original ResearchConceptsSeparate tumor nodulesPrimary lung cancerLung cancerTumor nodulesEighth editionTNM classificationSurvival differencesSecond primary lung cancerIASLC Lung Cancer Staging ProjectLung Cancer Staging ProjectForthcoming Eighth EditionSame histologic appearanceProportion of patientsSurvival of patientsLung cancer databaseT3 tumorsT4 tumorsIndex tumorCancer DatabaseSuch tumorsHistologic appearanceAnatomic classificationPatientsTumorsCancer
2014
Development of the International Thymic Malignancy Interest Group International Database: An Unprecedented Resource for the Study of a Rare Group of Tumors
Huang J, Ahmad U, Antonicelli A, Catlin AC, Fang W, Gomez D, Loehrer P, Lucchi M, Marom E, Nicholson A, Ruffini E, Travis W, Van Schil P, Wakelee H, Yao X, Detterbeck F, Committee and Contributors O. Development of the International Thymic Malignancy Interest Group International Database: An Unprecedented Resource for the Study of a Rare Group of Tumors. Journal Of Thoracic Oncology 2014, 9: 1573-1578. PMID: 25521402, DOI: 10.1097/jto.0000000000000269.Peer-Reviewed Original ResearchConceptsInternational Thymic Malignancy Interest GroupThymic carcinomaThymic carcinoidMedian overall survivalSingle-institution seriesOverall survivalThymic malignanciesMyasthenia gravisRare tumorHistologic classificationSex distributionThymomaCarcinoidsCarcinomaRetrospective dataType B2Rare groupTumorsPatientsMalignancyGreater proportionInternational databasesYearsGravisGroupApproaching the Patient with an Anterior Mediastinal Mass: A Guide for Radiologists
Carter BW, Okumura M, Detterbeck FC, Marom EM. Approaching the Patient with an Anterior Mediastinal Mass: A Guide for Radiologists. Journal Of Thoracic Oncology 2014, 9: s110-s118. PMID: 25396307, DOI: 10.1097/jto.0000000000000295.Peer-Reviewed Original ResearchA Practical Guide from the International Thymic Malignancy Interest Group (ITMIG) Regarding the Radiographic Assessment of Treatment Response of Thymic Epithelial Tumors Using Modified RECIST Criteria
Benveniste MF, Korst RJ, Rajan A, Detterbeck FC, Marom EM. A Practical Guide from the International Thymic Malignancy Interest Group (ITMIG) Regarding the Radiographic Assessment of Treatment Response of Thymic Epithelial Tumors Using Modified RECIST Criteria. Journal Of Thoracic Oncology 2014, 9: s119-s124. PMID: 25396308, DOI: 10.1097/jto.0000000000000296.Peer-Reviewed Original ResearchConceptsInternational Thymic Malignancy Interest GroupTumor measurementsProgression-free survivalThymic epithelial tumorsStandard outcome measuresMulti-institutional studyAccurate tumor measurementsRECIST criteriaTumor responseClinical trialsRadiographic assessmentTreatment responseEpithelial tumorsOutcome measuresResponse rateInterobserver variabilityThymomaPractical guideInterest group recommendationsChemotherapyPleuraTumorsClinical Presentation and Evaluation of Neuroendocrine Tumors of the Lung
Detterbeck FC. Clinical Presentation and Evaluation of Neuroendocrine Tumors of the Lung. Thoracic Surgery Clinics 2014, 24: 267-276. PMID: 25065927, DOI: 10.1016/j.thorsurg.2014.04.002.Peer-Reviewed Original ResearchConceptsCell lung cancerCarcinoid tumorsLung cancerNeuroendocrine tumorsLimited biopsyNon-small cell lung cancerLarge cell neuroendocrine cancerMost non-small cell lung cancersSmall cell lung cancerPeripheral parenchymal lesionAtypical carcinoid tumorTypical carcinoid tumorNode enlargementEndobronchial tumorMediastinal tumorCharacteristic presentationClinical presentationParenchymal lesionsNeuroendocrine cancerRapid progressionTumorsCancerBiopsyLungPresentationITMIG Consensus Statement on the Use of the WHO Histological Classification of Thymoma and Thymic Carcinoma: Refined Definitions, Histological Criteria, and Reporting
Marx A, Ströbel P, Badve SS, Chalabreysse L, Chan JK, Chen G, de Leval L, Detterbeck F, Girard N, Huang J, Kurrer MO, Lauriola L, Marino M, Matsuno Y, Molina TJ, Mukai K, Nicholson AG, Nonaka D, Rieker R, Rosai J, Ruffini E, Travis WD. ITMIG Consensus Statement on the Use of the WHO Histological Classification of Thymoma and Thymic Carcinoma: Refined Definitions, Histological Criteria, and Reporting. Journal Of Thoracic Oncology 2014, 9: 596-611. PMID: 24722150, DOI: 10.1097/jto.0000000000000154.Peer-Reviewed Original ResearchConceptsThymic carcinomaThymic epithelial tumorsB3 thymomaEpithelial tumorsInternational Thymic Malignancy Interest GroupWorld Health Organization classificationPoor interobserver reproducibilityHistological patternOrganization classificationConsensus statementHistological classificationHistological criteriaThymoma subtypesThymomaAtypical typeGrading systemInterobserver reproducibilityTumorsCarcinomaReproducibility studyRefined criteriaMorphological overlapSubtypesVariable proportions
2013
The international thymic malignancy interest group.
Detterbeck FC. The international thymic malignancy interest group. Journal Of The National Comprehensive Cancer Network 2013, 11: 589-93. PMID: 23667208, DOI: 10.6004/jnccn.2013.0074.Peer-Reviewed Original ResearchConceptsInternational Thymic Malignancy Interest GroupNCCN Clinical Practice GuidelinesMore evidence-based guidelinesSeries of patientsClinical practice guidelinesEvidence-based guidelinesSignificant clinical valueThymic tumorsTreatment recommendationsPractice guidelinesClinical valueOrphan diseaseGuidelinesPatientsGroupTumorsDiseaseOncology
2010
Management of Carcinoid Tumors
Detterbeck FC. Management of Carcinoid Tumors. The Annals Of Thoracic Surgery 2010, 89: 998-1005. PMID: 20172187, DOI: 10.1016/j.athoracsur.2009.07.097.Peer-Reviewed Original ResearchConceptsAtypical carcinoidCarcinoid tumorsBronchopulmonary carcinoidsParenchyma-sparing techniquesMainstay of treatmentN2 involvementNodal enlargementMediastinal nodesMultimodality treatmentClinical presentationDistant metastasisCentral tumorsHigh suspicionSurgical interventionStaging testsTypical carcinoidModerate suspicionCarcinoidsYounger ageTumorsMediastinoscopySignificant proportionTreatmentSuspicionCell typesCoping with the unexpected at surgery
Detterbeck FC, Terrien CM. Coping with the unexpected at surgery. Expert Review Of Respiratory Medicine 2010, 4: 115-122. PMID: 20387297, DOI: 10.1586/ers.09.59.Peer-Reviewed Original ResearchConceptsLung cancer surgeryMultidisciplinary tumor boardN2 node involvementPN2 diseaseNode involvementT4 tumorsExperienced centersSuch patientsCancer surgeryPreoperative assessmentTumor boardChest wallBetter outcomesIntraoperative surprisesSurgeryResectionMediastinalPatientsTumorsCareful planningDisease
2004
Seeking a Home for a PET, Part 1 Defining the Appropriate Place for Positron Emission Tomography Imaging in the Diagnosis of Pulmonary Nodules or Masses
Detterbeck FC, Falen S, Rivera MP, Halle JS, Socinski MA. Seeking a Home for a PET, Part 1 Defining the Appropriate Place for Positron Emission Tomography Imaging in the Diagnosis of Pulmonary Nodules or Masses. CHEST Journal 2004, 125: 2294-2299. PMID: 15189954, DOI: 10.1378/chest.125.6.2294.Peer-Reviewed Original ResearchConceptsPositron emission tomographyLung cancerPulmonary nodulesEmission tomographyTypical carcinoid tumorEvaluation of symptomsIntermediate riskCarcinoid tumorsPulmonary lesionsBronchioloalveolar carcinomaRisk factorsHigh riskRadiographic appearancePatientsPET imagingLesionsDiagnosisLittle roleCancerTomographyRiskNodulesCarcinomaSymptomsTumorsEndobronchial clear cell adenocarcinoma occurring in a patient 15 years after treatment for DES-associated vaginal clear cell adenocarcinoma
Hall WB, Detterbeck FC, Livasy CA, Fowler WC. Endobronchial clear cell adenocarcinoma occurring in a patient 15 years after treatment for DES-associated vaginal clear cell adenocarcinoma. Gynecologic Oncology 2004, 93: 708-710. PMID: 15196869, DOI: 10.1016/j.ygyno.2004.03.014.Peer-Reviewed Original ResearchConceptsClear cell adenocarcinomaCell adenocarcinomaInitial diagnosisVaginal clear cell adenocarcinomaParenchymal pulmonary metastasesMost recurrencesPulmonary metastasesCancer survivorsCase reportPrenatal exposurePrimary tumorAdenocarcinomaYoung womenDiethylstilbestrolDiagnosisTreatmentYearsCervixRecurrenceMetastasisTumorsVaginaSurvivorsWomenThymic tumors
Detterbeck FC, Parsons AM. Thymic tumors. The Annals Of Thoracic Surgery 2004, 77: 1860-1869. PMID: 15111216, DOI: 10.1016/j.athoracsur.2003.10.001.Peer-Reviewed Original ResearchConceptsComplete resectionThymic tumorsMainstay of treatmentSurvival of patientsIVA thymomaPostoperative radiotherapyThymic carcinomaPreoperative chemotherapyIndolent coursePartial resectionStage IIIResectionThymomaPatientsAggressive behaviorTumorsLittle benefitSuch casesChemotherapyCarcinomaRadiotherapyMainstay
2003
Diagnosis of Lung Cancer* The Guidelines
Rivera MP, Detterbeck F, Mehta AC. Diagnosis of Lung Cancer* The Guidelines. CHEST Journal 2003, 123: 129s-136s. PMID: 12527572, DOI: 10.1378/chest.123.1_suppl.129s.Peer-Reviewed Original ResearchConceptsLung cancerAbnormal chest radiograph findingsOverall clinical statusChest radiograph findingsPresence of metastasesUnnecessary invasive proceduresAvailable diagnostic proceduresMethods of diagnosisRadiograph findingsClinical presentationClinical statusPrimary tumorIndividual patientsInvasive proceduresSystemic effectsParticular patientCancerDiagnostic proceduresDiagnostic approachPatientsDiagnostic issuesDiagnosisTumorsCareful judgmentMetastasis